|
Squamous cell carcinoma of esophagus
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
<i>Conclusion:</i> Our results establish the functional role of RNF128 in driving the invasion and metastasis of ESCC through the EGFR/MAPK/MMP-2 pathway, implicating its potential as a candidate therapeutic target and prognostic biomarker for ESCC.
|
31216681 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
(2) The expressions of VEGF, HER-2, and EGFR mRNA were related to the lymph node metastasis in ESCC and pathologic differentiation degree.
|
26099724 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
ESCC shows a relatively high incidence of EGFR (50% - 70%), and the humanized monoclonal antibody (mAb) cetuximab against EGFR has been undergoing clinical development.
|
25242085 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Epidermal growth factor receptor and cyclin D1 are independently amplified and overexpressed in esophageal squamous cell carcinoma.
|
15672286 |
2005 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
EGFR and c-Fos expression can predict the tumor stage. c-Fos and c-erb-B2 expression can be used to determine the depth of tumor invasion and can also act as a combined prognostic indicator in ESCC.
|
24052437 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
EGFR:rs2227983 and 3 SNPs of PIK3CA also showed borderline significant correlation with OS of advanced ESCC patients (P = 0.058 for rs2227983; P = 0.069, 0.091 and 0.067 for rs6443624, rs7651265 and rs7621329 of PIK3CA respectively).
|
24945674 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
EGFR over-expression is probably a valuable predictor for the T stage, vascular invasion and OS, and it could be used as a poor prognosis indicator for the esophageal SCC patients.
|
25081654 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
EGFR family protein expression was examined by immunohistochemical analysis of tissue microarrays of 94 patients with lymph node-negative ESCC after radical esophagectomy with three-field lymphadenectomy.
|
29729836 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
A better understanding of the detailed mechanisms involved in EGFR and/or HER2 may help identify new therapeutic targets in esophageal SCC.
|
23232268 |
2012 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
A member of the epidermal growth factor receptor (EGFR) family, c-erbB-2, has received much attention because of its therapeutic implications; however, few studies involving fluorescence in situ hybridization (FISH) analysis of HER-2/neu gene amplification and protein expression in ESCC have been conducted.
|
19128465 |
2009 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
Another esophageal squamous cell carcinoma cell line CE81T/VGH (CE81T) was found to be resistant to Photofrin-induced inhibition of EGFR as well as to Photofrin-mediated dark toxicity compared with CE48T.
|
22585382 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
As reported, epidermal growth factor receptor (EGFR) is over expressed in a variety of cancers including esophageal squamous cell carcinoma.
|
22311160 |
2012 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
Both ESCC cell lines and PDXs with EGFR CNG or overexpression are potential candidates for afatinib, and concomitant EGFR/SFKs inhibition could reverse afatinib-acquired resistance caused by SFKs activation in ESCC.
|
30157900 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma.
|
28059068 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53 mutation can invade into the extracellular matrix when grown in 3D-organotypic cultures (OTC) and mimic early invasion in esophageal squamous cell carcinoma (ESCC).
|
25795715 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Expression of P-EGFR and P-Akt protein in esophageal squamous cell carcinoma and its prognosis.
|
28927043 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
For this phase 2, single-arm, multicenter trial undertaken at six hospitals in China, we included Chinese patients with previously treated, histologically confirmed advanced ESCC and EGFR overexpression (immunohistochemical staining sore of 3+) or amplification (positive fluorescence in situ hybridization result).
|
26980473 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Functional studies demonstrate that PCLO knockdown remarkably attenuates ESCC malignancy in vitro and in vivo, and ectopic EGFR expression partially compensates for Piccolo loss.
|
28263981 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, Met activation is increased upon combinatorial overexpression of epidermal growth factor receptor (EGFR) and p53(R175H), two common genetic mutations in ESCC.
|
20534479 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a Chinese population.
|
23874846 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
However, the specific effects of miR-133b and EGFR on ESCC remain unclear.
|
30594787 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Identification of exon 19 and 21 mutations of EGFR gene in Chinese patients with esophageal squamous cell carcinoma.
|
24103528 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Importantly, we proved that RhoE could negatively regulate the protein expression of EGFR and p-ERK, suggesting that RhoE might inhibit ESCC progression through the EGFR/ERK pathway.
|
27721256 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In ESCC cell lines with EGFR high expression, PD-L1 expression was induced significantly when EGFR signaling was activated by radiation and was dramatically inhibited by an EGFR tyrosine kinase inhibitor.
|
28192623 |
2017 |