|
Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis of the EGFR gene in astrocytic gliomas: mRNA expression, quantitative-PCR analysis of non-homogeneous gene amplification and DNA sequence alterations.
|
16008822 |
2005 |
|
Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Amplification and mutation of the epidermal growth factor receptor (EGFR) is common in astrocytoma.
|
15580296 |
2005 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of amplified epidermal growth factor receptor favors the diagnosis of high-grade astrocytomas over anaplastic oligodendroglioma, which is especially relevant for small cell astrocytomas.
|
16203285 |
2005 |
|
Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis of the erbB gene family calmodulin-binding and calmodulin-like domains in astrocytic gliomas.
|
15492843 |
2004 |
|
Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No small cell astrocytomas had 1p/19q codeletions, whereas EGFR amplification and 10q deletions were present in 69% and 97% of small cell astrocytomas, respectively.
|
15470710 |
2004 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An intriguing observation in astrocytomas and oligodendrogliomas grade II, was a significantly decreased overall survival for patients with high EGFR protein expression (P= 0.04).
|
15148612 |
2004 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To determine whether EGFR overexpression could modify the tumor phenotype in our previously reported GFAP-V(12)Ha-ras transgenic mouse astrocytoma model, mice expressing both activated RAS and EGFR were developed.
|
12615729 |
2003 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glioblastoma multiforme arises either de novo as a primary glioblastomas associated with epidermal growth factor receptor (EGFR) and mdm2 over-expression or as a secondary glioblastomas, through malignant progression from low-grade astrocytomas, associated with p53 mutations and PDGFR-alpha over-expression.
|
12635658 |
2002 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, de novo high grade pediatric astrocytomas lack amplification of the EGFR gene compared with EGFR amplification in one-third of adult glioblastomas.
|
10764044 |
2000 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lysophosphatidic acid inhibits Ca2+ signaling in response to epidermal growth factor receptor stimulation in human astrocytoma cells by a mechanism involving phospholipase C(gamma) and a G(alphai) protein.
|
10987838 |
2000 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stable expression of activated Ki-Ras does not constitutively activate the mitogen-activated protein kinase pathway but attenuates epidermal growth factor receptor activation in human astrocytoma cells.
|
9863009 |
1999 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, EGFR amplification, which is usually observed in approximately 40% and 15% of adult grade 4 and grade 3 astrocytomas, respectively, was not detected in any member of this series.
|
10632344 |
1999 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Under two conditions (10% FCS and 0.5% FCS plus 20 ng/ml EGF), cells acquired the ability to form colonies in soft agarose and tumors in nude mice, and this was accompanied by the expression of genes, including epidermal growth factor receptor, platelet-derived growth factor receptor alpha and beta, protein kinase Cdelta, and vascular endothelial growth factor, which are known to be aberrantly regulated in human astrocytomas.
|
10074901 |
1999 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We studied EGFR gene alterations using the polymerase chain reaction and EGFR gene expression of 65 astrocytic tumors (51 glioblastomas World Health Organization [WHO] IV, five anaplastic astrocytomas WHO III, and nine astrocytomas WHO II).
|
10029453 |
1999 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The clonal progression of human astrocytomas to a more malignant phenotype often involves the amplification and overexpression of the epidermal growth factor receptor (EGFr) gene.
|
9096379 |
1997 |
|
Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data demonstrate that EGFR alterations are frequent events in astrocytic gliomas and are largely restricted to glioblastomas.
|
8814167 |
1996 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EGFR gene amplification occurred in astrocytomas, oligodendrogliomas, ependymomas and glioblastomas.
|
8568531 |
1995 |
|
Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Loss of heterozygosity (LOH) for chromosome arms 9p, 10p, 10q, and 17p and amplification of the epidermal growth factor receptor (EGFR) gene have been identified as frequent genetic changes in malignant astrocytomas.
|
7513547 |
1994 |
|
Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In contrast, about 50% of the high-grade tumor samples analyzed included abnormalities at two or more loci, with a recurrent association of EGFR amplification and LOH for chromosome 10; this association was evident in 26% of the high-grade astrocytomas.
|
8174086 |
1994 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found amplification of the EGFR gene in 49% (18/37) of GBM but not in the astrocytomas WHO II/III.
|
7760096 |
1994 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed EGFR gene amplification in astrocytomas and anaplastic astrocytomas with approximately the same incidence as in glioblastoma multiforme (33%), although large amplifications were only seen in glioblastoma multiforme.
|
1311022 |
1992 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Co-overexpression of c-erbB-1 and c-fos was frequently observed in low grade astrocytomas and may be predictive of non-progression.
|
1322154 |
1992 |
|
Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amplified, overexpressed and rearranged epidermal growth factor receptor gene in a human astrocytoma cell line.
|
2994648 |
1985 |