Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
It is used in the treatment of non-small cellular lung carcinoma and spares wild-type EGFR.
|
31539712 |
2020 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, patients lacking EGFR mutations are not sensitive to EGFR-TKI treatment and the emergence of secondary resistance poses new challenges for the targeted therapy of lung cancer.
|
31777985 |
2020 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PET/CT images of lung cancer patients were obtained from public databases and used to establish two datasets, respectively to classify histological subtypes (156 adenocarcinomas and 32 squamous cell carcinomas) and EGFR mutation status (38 mutant and 100 wild-type samples).
|
31659591 |
2020 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
We investigated whether A2B receptor is involved in EGFR translocation and DNA damage response (γH2AX/53BP1 focus formation) of lung cancer cells by means of immunofluorescence studies.
|
31678144 |
2020 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Besides being a predictive biomarker of response to immunotherapy in lung cancer in general, programmed death-ligand 1 (PD-L1) is not so well correlated with treatment outcomes of lung adenocarcinoma (ADC) harbouring epidermal growth factor receptor (EGFR) mutations, as reported studies are inconclusive and seldom addressed the issues of response to treatment and resistance.
|
31760310 |
2020 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
There are numerous biomarkers for the lung cancer such as EGFR, CEA, CYFRA 21-1, ENO1, NSE, CA 19-9, CA 125 and VEGF.
|
31514848 |
2020 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
The role of serum tumor markers (STMs) in the modern management of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutations in lung cancer remains poorly described.
|
31707279 |
2020 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Of the 9 patients analysed, 7 carried oncogene-addicted LC (4 EGFR, 1 B-RAF and 2 ALK) and five out of 7 carried BRCA mutations.
|
31662533 |
2020 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Several growth related genes such as EGFR and VEGF as well as tumour suppressor genes such as p53 have been implicated in LC pathogenesis and progression.
|
31770191 |
2020 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Phase I study of vorinostat with gefitinib in BIM deletion polymorphism/EGFR mutation double-positive lung cancer.
|
31782583 |
2020 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions:</b> In conclusion, metformin may potentially enhance the therapeutic effect and increase survival in type 2 DM patients with lung cancer receiving EGFR-TKI therapy.
|
31409137 |
2020 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Correction: Role of IGF-Binding Protein 3 in the Resistance of EGFR Mutant Lung Cancer Cells to EGFR-Tyrosine Kinase Inhibitors.
|
30870512 |
2019 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate the adequacy of EBUS-TBNA in providing adequate size specimens for EGFR, ALK and ROS1 genetic mutation analysis in patients with adenocarcinoma or not otherwise specified (NOS) lung cancer.
|
30582673 |
2019 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Erlotinib is a targeted anticancer therapy used for treating epidermal growth factor receptor (EGFR) mutation positive lung cancer in advanced stage as well as for other malignancies.
|
30679984 |
2019 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in ALK-positive lung cancer: Comparison with EGFR-mutated lung cancer.
|
30580903 |
2019 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
<b>Purpose:</b> Drug resistance is a major challenge for epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) treatment of lung cancer.
|
31417255 |
2019 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The coexistence of epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement in patients with multifocal lung adenocarcinomas (LUAC) constitutes a rare molecular subtype of lung cancer.
|
31138506 |
2019 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine the sensitivity of MASS-PCR, 717 lung cancer specimens, 61 formalin-fixed paraffin-embedded (FFPE) tissues, and 656 fresh reaction tissues are collected and undergo mutation detection of lung cancer driver genes (EGFR, KRAS, BRAF, HER2, MET, ALK, and ROS1).
|
30677225 |
2019 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
In conclusion, the identified DEGs, particularly the hub genes, strengthen the understanding of the development and progression of lung cancer, and certain genes (including advanced glycosylation end‑product specific receptor and epidermal growth factor receptor) may be used as candidate target molecules to diagnose, monitor and treat lung cancer.
|
30664219 |
2019 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We searched four databases for all original articles on family history of malignancy and EGFR mutation status in lung cancer published up to July 2018.
|
31703574 |
2019 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
The treatment of lung cancer has also evolved with the introduction of several lines of tyrosine kinase inhibitors in patients with EGFR, ALK, ROS1, and NTRK mutations.
|
31378236 |
2019 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this review is to: 1) analyze various preanalytical, analytical, and postanalytical factors influencing ICC results; 2) discuss measures for validation of ICC protocols; and 3) summarize published data on predictive ICC for ALK, ROS1, EGFR gene alterations and PD-L1 expression on lung cancer cytology.
|
31050216 |
2019 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A 79-year-old woman had disease progression during third-line treatment with osimertinib for an EGFR L858R/T790M-mutant lung cancer.
|
31254668 |
2019 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma oncogene (KRAS) signaling pathways play a critical role in the proliferation and progression of various cancers, including lung cancer.
|
30132854 |
2019 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutation tracking of a patient with EGFR-mutant lung cancer harboring de novo MET amplification: Successful treatment with gefitinib and crizotinib.
|
30797494 |
2019 |