|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Our results have demonstrated that TILs have three different gene expression profiles: the first set of genes is involved in cell proliferation and mitogenic stimulation, such as c-myc and IL-8, LD78, MIP-1beta, insulin-induced protein and AH-receptor; the second set of genes includes those involved in attachment of lymphocytes to endothelium and extravasation into tumor tissues such as P-selectin ligand and integrin; and the third set, which includes genes such as the perforin, FAS ligand and granzyme B, is related to cytotoxic function to tumor cells.
|
11024287 |
2000 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other aryl hydrocarbon receptor (AhR) ligands suppress 17beta-estradiol (E)-induced responses in the rodent uterus and mammary tumors and in human breast cancer cells.
|
12612060 |
2003 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
High levels of apparently active AhR characterize a variety of tumors, even in the absence of environmental ligands.
|
16091746 |
2005 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Since dioxins are not directly genotoxic their carcinogenic effect is likely the result of their tumor promoting activity produced by activation of the AhR.
|
16054739 |
2005 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Data demonstrating high levels of constitutively active AhR in mammary tumors are summarized.
|
16972784 |
2006 |
|
Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
AhR promoter CpG methylation was sporadic in a panel of 19 tumor cell lines except for the chronic myeloid leukemia (CML) K562 and the acute lymphoblastic leukemia (ALL) REH.
|
16410262 |
2006 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Collectively, these results offer insights into the mechanisms underlying the procarcinogenic effects of TS and raise the possibility that inhibitors of EGFR or aryl hydrocarbon receptor signaling will prevent or delay the development of TS-related tumors.
|
19138943 |
2008 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Elevated AhR and CYP1B1 but not CYP1A1 before tumor formation in a rat model of mammary tumorigenesis suggested differential CYP1B1 regulation by a constitutively active AhR.
|
18059014 |
2008 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We used a xenograft model to investigate whether the aryl hydrocarbon receptor deletion construct CDelta553 suppresses tumor growth.
|
19695250 |
2009 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Activation of the aryl hydrocarbon receptor (AHR) with exogenous ligands coupled with inflammatory signals can lead to synergistic induction of IL6 expression in tumor cells.
|
20106948 |
2010 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
TDO-derived Kyn suppresses antitumour immune responses and promotes tumour-cell survival and motility through the AHR in an autocrine/paracrine fashion.
|
21976023 |
2011 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These findings led to the hypothesis that the basal AhR activity in HNSCCs plays a role in the aggressive phenotype of these tumors and that antagonist treatment could mitigate this phenotype.
|
22912337 |
2012 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Microarray analysis revealed aryl hydrocarbon receptor (AhR) signalling as one of the top networks that is differentially regulated in MCF7(TAM-R) and MCF7 xenograft tumours treated with AMD3100.
|
22644306 |
2012 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms.
|
22037238 |
2012 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Therefore, this study evaluated whether the AhR serves a pro-proliferative role in an immortalized MB tumor cell line (DAOY).
|
22311706 |
2012 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In conclusion, AIP is involved in the aggressiveness of sporadic GH-PA, regardless of Gsp status, and AIP up-regulation in SSA-treated tumours is associated with a better preoperative response, with no clear role for AHR.
|
23940012 |
2013 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Expression of IGF2 was higher in tumors than in healthy lung tissue in never-smokers (p=0.003), and expression of AHR (p<0.0001), CSF1R (p<0.0001) and RRAD (p<0.0001) was lower in tumors than in healthy lung tissue in smokers.
|
24451080 |
2013 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line.
|
23733406 |
2013 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Here we sought to identify putative novel targets of the AHR associated with enhanced tumor invasiveness.
|
23625689 |
2014 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Evidence from transfection studies implies that AIP acts as a tumor suppressor; although whether this is mediated through an interaction with the aryl hydrocarbon receptor, phosphodiesterases, or with cell cycle regulators such as survivin or RET remains controversial.
|
24366639 |
2014 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
However, the AhR can also inhibit cellular proliferation in a ligand-dependent manner and act as a tumor suppressor in mice, and thus may be a potential anticancer target.
|
24481452 |
2014 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell.
|
26242870 |
2015 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
This review will summarize recent findings on the interesting and complicated underlying mechanisms that miRNAs interact with HIFs or AHR in tumors, hopefully to benefit the discovery of novel drug-interfering targets for cancer therapy.
|
25997457 |
2015 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
On the other hand, in the tumor tissue from human colon cancer and that developed in Apc(Min/+)mice, AhR expression was elevated.
|
26973338 |
2016 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The net biologic effect of AHR activation by endogenous ligands, which can be mimicked by environmental ligands, is an increase in tumor cell migration, a measure of tumor aggressiveness.
|
27573671 |
2016 |