AHR, aryl hydrocarbon receptor, 196

N. diseases: 532; N. variants: 20
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease BEFREE Aryl hydrocarbon receptor activation alleviates dextran sodium sulfate-induced colitis through enhancing the differentiation of goblet cells. 31029423 2019
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease BEFREE The therapeutic effect of NPD-0414-2 and NPD-0414-24 on the ongoing colitis was abrogated in AhR-deficient mice. 31031628 2019
CUI: C0009319
Disease: Colitis
Colitis
0.400 AlteredExpression disease BEFREE Finally, the correlation between NOR-mediated activation of AhR, repression of glycolysis, regulation of NAD<sup>+</sup>/SIRT1/SUV39H1/H3K9me3 signals, induction of Treg cells, and remission of colitis was confirmed in mice with DSS-induced colitis by using CH223191 and HK2 plasmid. 29449535 2018
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease BEFREE Further, the increase of both MLC phosphorylation and MLCK expression in the mice with DSS-induced colitis was also significantly inhibited by FICZ induced AhR activation. 29483826 2018
CUI: C0009319
Disease: Colitis
Colitis
0.400 AlteredExpression disease BEFREE Our data show that AhR activation by FICZ ameliorated colonic inflammation, decreased IL-6 and claudin-2 expression, and maintained intestinal barrier function in a mouse model of dextran sulphate sodium (DSS)-induced colitis. 29680209 2018
CUI: C0009319
Disease: Colitis
Colitis
0.400 AlteredExpression disease BEFREE Finally, correlations between activation of AhR and attenuation of colitis, inhibition of NLRP3 inflammasome activation and up-regulation of Nrf2 level in colons were validated in mice with TNBS-induced colitis. 29576052 2018
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease BEFREE In conclusion, alpinetin ameliorated colitis in mice via activating AhR, regulating miR-302/DNMT-1/CREB signals, therefore promoting Treg differentiation. 30166541 2018
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease BEFREE These results suggested that AhR deficiency resulted in increased susceptibility to colitis, whereas activation of AhR by FICZ could ameliorate DSS‑induced colitis via the MK2/p‑MK2/TTP pathway. 29207040 2018
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease BEFREE Thus, we conducted this study to investigate whether dietary tryptophan supplementation protects against DSS-induced colitis by acting through Ahr. 28113104 2017
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease BEFREE Aryl hydrocarbon receptor activation modulates CD8αα<sup>+</sup>TCRαβ<sup>+</sup> IELs and suppression of colitis manifestations in mice. 28049094 2017
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease BEFREE Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation. 27900483 2017
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease BEFREE The microbiota from CARD9 mice fails to metabolize tryptophan leading to defective AhR activation which contributes to the susceptibility of mice to colitis by decreased interleukin 22 production. 28399013 2017
CUI: C0009319
Disease: Colitis
Colitis
0.400 AlteredExpression disease BEFREE Furthermore, Ahr-expressing Tregs had enhanced in vivo suppressive activity compared with Tregs lacking Ahr expression in a T cell transfer model of colitis. 29166616 2017
CUI: C0009319
Disease: Colitis
Colitis
0.400 Therapeutic disease CTD_human AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. 27783946 2016
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease BEFREE Aryl hydrocarbon receptor and colitis. 23928874 2013
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease BEFREE In cell culture experiments, downregulation of AhR in human colon carcinoma SW480 cells enhanced the inflammatory responses evoked by lipopolysaccharide (LPS), and furthermore, AhR activation attenuated LPS-induced inflammatory responses, suggesting that AhR expressing intestinal epithelial cells are involved in the prevention of colitis. 21374063 2011
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease BEFREE This strain of lactic acid bacterium has therefore the potential to activate the AhR pathway, which may be able to suppress colitis. 21321579 2011
CUI: C0009319
Disease: Colitis
Colitis
0.400 AlteredExpression disease BEFREE Attenuation of the AhR receptor expression resulted in a protective effect during DSS-induced colitis, while the absence of AhR exacerbated the disease. 20878756 2011
CUI: C0009319
Disease: Colitis
Colitis
0.400 AlteredExpression disease BEFREE This study investigated whether the activation of the AhR pathway affects dextran sodium sulfate (DSS)-induced colitis, an ulcerative colitis-like model, in mice. 20231854 2010