Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Aryl hydrocarbon receptor activation alleviates dextran sodium sulfate-induced colitis through enhancing the differentiation of goblet cells.
|
31029423 |
2019 |
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The therapeutic effect of NPD-0414-2 and NPD-0414-24 on the ongoing colitis was abrogated in AhR-deficient mice.
|
31031628 |
2019 |
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Finally, the correlation between NOR-mediated activation of AhR, repression of glycolysis, regulation of NAD<sup>+</sup>/SIRT1/SUV39H1/H3K9me3 signals, induction of Treg cells, and remission of colitis was confirmed in mice with DSS-induced colitis by using CH223191 and HK2 plasmid.
|
29449535 |
2018 |
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Further, the increase of both MLC phosphorylation and MLCK expression in the mice with DSS-induced colitis was also significantly inhibited by FICZ induced AhR activation.
|
29483826 |
2018 |
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our data show that AhR activation by FICZ ameliorated colonic inflammation, decreased IL-6 and claudin-2 expression, and maintained intestinal barrier function in a mouse model of dextran sulphate sodium (DSS)-induced colitis.
|
29680209 |
2018 |
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Finally, correlations between activation of AhR and attenuation of colitis, inhibition of NLRP3 inflammasome activation and up-regulation of Nrf2 level in colons were validated in mice with TNBS-induced colitis.
|
29576052 |
2018 |
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, alpinetin ameliorated colitis in mice via activating AhR, regulating miR-302/DNMT-1/CREB signals, therefore promoting Treg differentiation.
|
30166541 |
2018 |
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggested that AhR deficiency resulted in increased susceptibility to colitis, whereas activation of AhR by FICZ could ameliorate DSS‑induced colitis via the MK2/p‑MK2/TTP pathway.
|
29207040 |
2018 |
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, we conducted this study to investigate whether dietary tryptophan supplementation protects against DSS-induced colitis by acting through Ahr.
|
28113104 |
2017 |
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Aryl hydrocarbon receptor activation modulates CD8αα<sup>+</sup>TCRαβ<sup>+</sup> IELs and suppression of colitis manifestations in mice.
|
28049094 |
2017 |
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation.
|
27900483 |
2017 |
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The microbiota from CARD9 mice fails to metabolize tryptophan leading to defective AhR activation which contributes to the susceptibility of mice to colitis by decreased interleukin 22 production.
|
28399013 |
2017 |
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, Ahr-expressing Tregs had enhanced in vivo suppressive activity compared with Tregs lacking Ahr expression in a T cell transfer model of colitis.
|
29166616 |
2017 |
Colitis
|
0.400 |
Therapeutic
|
disease |
CTD_human |
AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.
|
27783946 |
2016 |
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Aryl hydrocarbon receptor and colitis.
|
23928874 |
2013 |
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In cell culture experiments, downregulation of AhR in human colon carcinoma SW480 cells enhanced the inflammatory responses evoked by lipopolysaccharide (LPS), and furthermore, AhR activation attenuated LPS-induced inflammatory responses, suggesting that AhR expressing intestinal epithelial cells are involved in the prevention of colitis.
|
21374063 |
2011 |
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This strain of lactic acid bacterium has therefore the potential to activate the AhR pathway, which may be able to suppress colitis.
|
21321579 |
2011 |
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Attenuation of the AhR receptor expression resulted in a protective effect during DSS-induced colitis, while the absence of AhR exacerbated the disease.
|
20878756 |
2011 |
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study investigated whether the activation of the AhR pathway affects dextran sodium sulfate (DSS)-induced colitis, an ulcerative colitis-like model, in mice.
|
20231854 |
2010 |