AHR, aryl hydrocarbon receptor, 196

N. diseases: 532; N. variants: 20
Disease: Congenital Heart Defects ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018798
Disease: Congenital Heart Defects
Congenital Heart Defects 		0.320 Biomarker group BEFREE Previously, we demonstrated that extractable organic matter (EOM) from PM2.5 induced heart defects in zebrafish embryos by activating the aromatic hydrocarbon receptor (AHR). 31837856 2020
CUI: C0018798
Disease: Congenital Heart Defects
Congenital Heart Defects 		0.320 Biomarker group BEFREE In this study, we found that the reactive oxygen species (ROS) scavenger, N-Acetyl-L-cysteine (NAC), and AHR inhibitors, CH223191 (CH) and StemRegenin 1, significantly counteracted the TCE-induced heart malformations in zebrafish embryos. 31699484 2020
CUI: C0018798
Disease: Congenital Heart Defects
Congenital Heart Defects 		0.320 Biomarker group CTD_human The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology. 19261855 2009