|
Congenital nystagmus
|
0.500 |
Biomarker
|
disease |
CTD_human |
Oculomotor deficits in aryl hydrocarbon receptor null mouse.
|
23301081 |
2013 |
|
Congenital nystagmus
|
0.500 |
Biomarker
|
disease |
MGD |
Oculomotor deficits in aryl hydrocarbon receptor null mouse.
|
23301081 |
2013 |
|
Congenital nystagmus
|
0.500 |
Biomarker
|
disease |
MGD |
Uric acid stones in the urinary bladder of aryl hydrocarbon receptor (AhR) knockout mice.
|
22232670 |
2012 |
|
Congenital nystagmus
|
0.500 |
Biomarker
|
disease |
MGD |
Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse.
|
12646173 |
2003 |
|
Congenital nystagmus
|
0.500 |
Biomarker
|
disease |
MGD |
Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor.
|
9427285 |
1997 |
|
Obesity
|
0.450 |
Biomarker
|
disease |
BEFREE |
The data demonstrate an important AHR-FGF21 regulatory axis that influences adipose biology and may represent a "druggable" therapeutic target for obesity and its related metabolic disorders.
|
30813227 |
2019 |
|
Obesity
|
0.450 |
AlteredExpression
|
disease |
BEFREE |
CNM (1) normalized serum estradiol-17β levels, (2) induced gastric Nrf2 and phase II antioxidant enzymes through extracellular signal-regulated kinase, (ERK)/c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (MAPK), (3) reduced glucose synthase kinase 3 beta (GSK3β) and aryl hydrocarbon receptor (AhR) and this was associated with (4) increased estrogen receptor expression, BH<sub>4</sub> (Cofactor of nNOS) biosynthesis enzyme GCH-1 and nNOSα dimerization in WT Obese/T2 diabetic female mice.
|
30831189 |
2019 |
|
Obesity
|
0.450 |
Biomarker
|
disease |
CTD_human |
The data demonstrate an important AHR-FGF21 regulatory axis that influences adipose biology and may represent a "druggable" therapeutic target for obesity and its related metabolic disorders.
|
30813227 |
2019 |
|
Obesity
|
0.450 |
Biomarker
|
disease |
BEFREE |
The pathophysiology of obesity is also associated with a state of aberrant inflammation that activates aryl hydrocarbon receptor (AHR), a pathway involved in the detection of intracellular or environmental changes as well as with increases in the production of TRYCATs, being KYN an agonists of AHR.
|
28595944 |
2018 |
|
Obesity
|
0.450 |
Biomarker
|
disease |
BEFREE |
In conclusion, although there are some sex- and Ahr allelic-dependent differences, AHR inhibition prevents obesity and liver steatosis in both males and females regardless of the ligand-binding capacity of the AHR.
|
28821316 |
2017 |
|
Obesity
|
0.450 |
Biomarker
|
disease |
CTD_human |
Studies are presented showing that the AHR antagonists α-naphthoflavone and CH-223191 significantly reduce obesity and adiposity and ameliorates liver steatosis in male C57Bl/6J mice fed a Western diet.
|
27020609 |
2016 |
|
Obesity
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
We tested first whether high coffee intake is associated with low risk of obesity, metabolic syndrome and type 2 diabetes, and with related components thereof, in observational analyses; second, whether five genetic variants near the CYP1A1, CYP1A2 and AHR genes are associated with coffee intake; and third, whether the genetic variants are associated with obesity, metabolic syndrome and type 2 diabetes, and with related components thereof.
|
26002927 |
2015 |
|
Obesity
|
0.450 |
Biomarker
|
disease |
HPO |
|
|
|
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, other reported AhR antagonists also upregulate utrophin, showing that this pathway, which is currently being explored in other clinical applications including oncology and rheumatoid arthritis, could also be exploited in future DMD therapies.
|
31755636 |
2020 |
|
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The aryl hydrocarbon receptor (AhR) is responsible for mediating different biological responses to a wide variety of environmental pollutants and also causes transcriptional activation of cytochrome P450 enzymes including CYP1B1 and thus plays a pivotal role for initiating cancer and its progression.
|
31563143 |
2020 |
|
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Here, we provide an overview of the role of AhR in the regulation of innate and adaptive immune response and discuss the implications of targeting this pathway to augment the immune response in cancer patients.
|
31816350 |
2020 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Malignant cells frequently evolve multiple mechanisms for suppressing tumor-specific responses, including the induction of suppressive pathways involving AhR and its metabolic byproducts in the tumor microenvironment that promote immune evasion and tumor progression.
|
31816350 |
2020 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Overall, our data demonstrated that FICZ, as an AhR agonist could induce the expression of tumor suppressor miRNAs, <i>miR-22, miR-515-5p,</i> and <i>miR-124-3p</i>; thus, FICZ might be regarded as a potential therapeutic agent for breast cancer treatment.
|
31606975 |
2020 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis.
|
31594926 |
2019 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study shows that smoking may be involved in the pathogenesis of RA by the AHR pathway.
|
30418118 |
2019 |
|
Rheumatoid Arthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Unbalanced expression of aryl hydrocarbon receptor in peripheral blood CCR6<sup>+</sup>CD4<sup>+</sup> and CD4<sup>+</sup>CD25<sup>+</sup>T cells of rheumatoid arthritis.
|
28535889 |
2019 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, has been shown to regulate the differentiation, activation and apoptosis of various cells involved in rheumatoid arthritis.
|
31811747 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Benzo[α]pyrene (BaP) can have significant role in the development of breast cancer via aryl hydrocarbon receptor (AhR) activation.
|
30294794 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aryl hydrocarbon receptor role in breast cancer pathophysiology may be mediated by an increase in cytochrome P450 (CYP)1b1 in mitochondria, leading to the backward conversion of melatonin to N-acetylserotonin (NAS).
|
31310736 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, AhR represents an attractive target to inhibit redox homeostasis and modulate the tumor promoting microenvironment of basal-like and BRCA1-associated BC.
|
30733286 |
2019 |