|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The human T cell leukemia virus I basic leucine zipper protein (HTLV-1 HBZ) maintains chronic viral infection and promotes leukemogenesis through poorly understood mechanisms involving interactions with the KIX domain of the transcriptional coactivator CBP and its paralog p300.
|
30232260 |
2018 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.
|
25893291 |
2016 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The combined results of this study provide evidence that the H3K9-me1/2 demethylase KDM3B might play a role in leukemogenesis via activation of lmo2 through interdependent actions with the histone acetyltransferase (HAT) complex containing CBP.
|
22615488 |
2012 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We use a murine model of lymphomagenesis to show the expression of eIF4F subunits is also up-regulated by c-Myc in vivo.
|
18593934 |
2008 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Of these, only eIF4E was able to enhance lymphomagenesis in vivo.
|
18708578 |
2008 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
As eukaryotic translation initiation factor 4E (eIF4E) cooperates with c-Myc during lymphomagenesis, induces drug resistance, and is a genetic modifier of the rapamycin response, we have investigated the effect of dysregulation of the ribosome recruitment phase of translation initiation on tumor progression and chemosensitivity. eIF4E is a subunit of eIF4F, a complex that stimulates ribosome recruitment during translation initiation by delivering the DEAD-box RNA helicase eIF4A to the 5' end of mRNAs. eIF4A is thought to prepare a ribosome landing pad on mRNA templates for incoming 40S ribosomes (and associated factors).
|
18551192 |
2008 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have shown that Bcl-2, Akt, and the translational regulator eIF4E cooperate with Myc during lymphomagenesis and are potent inducers of drug resistance.
|
15190216 |
2004 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The t(8;16) fuses the MOZ gene which encodes a histone acetyltransferase, located on 8p11 with the CBP gene which also encodes a histone acetyltransferase, located on 16p13, and recent reports suggested that the chimeric transcription MOZ-CBP is essential for leukemogenesis.
|
15160929 |
2004 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the t(11;16), 3' CBP, on 16p13, is fused to 5' MLL, on 11q23, resulting in an MLL-CBP fusion gene that plays an important role in leukemogenesis.
|
15334549 |
2004 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These studies indicate that the RNA transport function of eIF4E could contribute to leukemogenesis.
|
14645512 |
2003 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The transcriptional coactivators, CBP and p300, were found to be involved in leukemogenesis through translocations.
|
11071359 |
2000 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the only t(8;16) that has been described at the sequence level using RT-PCR, the CBP-MOZ fusion was found to be out-of-frame, suggesting that the reciprocal MOZ-CBP transcript is the essential one for leukemogenesis.
|
10862050 |
2000 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CBP is the first partner gene of MLL containing well defined structural and functional motifs that provide unique insights into the potential mechanisms by which these translocations contribute to leukemogenesis.
|
9238046 |
1997 |