ELANE, elastase, neutrophil expressed, 1991

N. diseases: 346; N. variants: 33
Disease: Periodontitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0031099
Disease: Periodontitis
Periodontitis 		0.140 Biomarker disease BEFREE However, the mechanism by which NE is released from human neutrophils and the role of NE in periodontitis is unclear. 30817027 2019
CUI: C0031099
Disease: Periodontitis
Periodontitis 		0.140 Biomarker disease BEFREE The main finding of this study was that subclinical periodontitis in adolescents was statistically significantly associated with elevated salivary aMMP-8 but not with PMN elastase. 30397915 2019
CUI: C0031099
Disease: Periodontitis
Periodontitis 		0.140 AlteredExpression disease BEFREE Salivary MDA and serum 4-HNE were significantly higher in the patients with periodontitis compared to the control group (p < 0.001). 27807715 2017
CUI: C0031099
Disease: Periodontitis
Periodontitis 		0.140 GeneticVariation disease BEFREE Using principal coordinate analysis of the subgingival microbiota, patients with ELANE mutations and reference subjects with periodontitis tended to cluster differently from patients with HAX1 or unknown mutations and non-periodontitis reference subjects. 21796505 2011
CUI: C0031099
Disease: Periodontitis
Periodontitis 		0.140 Biomarker disease HPO