|
Small cell carcinoma of lung
|
0.350 |
Biomarker
|
disease |
CTD_human |
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
|
22941189 |
2012 |
|
Small cell carcinoma of lung
|
0.350 |
AlteredExpression
|
disease |
LHGDN |
Molecular detection of neuron-specific ELAV-like-positive cells in the peripheral blood of patients with small-cell lung cancer.
|
18607064 |
2008 |
|
Small cell carcinoma of lung
|
0.350 |
Biomarker
|
disease |
BEFREE |
Fab GLN495 recognized HuD and other related proteins (HuC and Hel-N1, or Hu antigens) in immunoblots of these recombinant proteins and in immunohistochemical and Western blot analysis of SCLC and neurons.
|
9585817 |
1998 |
|
Small cell carcinoma of lung
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of the neuroendocrine genes Hel-N1 and HuD in small-cell lung carcinoma: evidence for down-regulation of HuD in the variant phenotype.
|
9291425 |
1997 |
|
Small cell carcinoma of lung
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
A homozygous deletion including Hel-N1 and CDKN2a was found in a SCLC cell line, and a single-base polymorphism in exon 2 of Hel-N1 was observed in eight tumors.
|
9393760 |
1997 |
|
Small cell carcinoma of lung
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma.
|
8619556 |
1996 |
|
Schizophrenia
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Identification of relevant hub genes for early intervention at gene coexpression modules with altered predicted expression in schizophrenia.
|
31715283 |
2020 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
BEFREE |
Proceeding investigations of G protein-coupled receptor (GPCR) heterocomplexes have demonstrated that the dopamine D2 receptor (D<sub>2</sub>R), one of the hub receptors in the physiology of schizophrenia, interacts with both the neurotensin NTS1 (NTS1R) and the serotonin 5-HT<sub>2A</sub> receptor (5-HT<sub>2A</sub>R) in cell lines and rodent brain tissue.
|
31704949 |
2019 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
PSYGENET |
In stage III, we scrutinized the ELAVL2 gene by genotyping gene-centric tagSNPs in the third sample set of 293 family samples (1,163 individuals) of Chinese descent and the SNP in the gene showed a nominal association with schizophrenia in Chinese population (p = 0.026).
|
21674006 |
2011 |
|
Schizophrenia
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
In stage III, we scrutinized the ELAVL2 gene by genotyping gene-centric tagSNPs in the third sample set of 293 family samples (1,163 individuals) of Chinese descent and the SNP in the gene showed a nominal association with schizophrenia in Chinese population (p = 0.026).
|
21674006 |
2011 |
|
Major Depressive Disorder
|
0.130 |
Biomarker
|
disease |
BEFREE |
Additionally, the identified hub genes were downregulated and show high functional similarity and diagnostic value in MDD.
|
31275757 |
2019 |
|
Major Depressive Disorder
|
0.130 |
Biomarker
|
disease |
BEFREE |
A weighted gene co-expression network analysis (WGCNA) was performed to identify significant gene modules and hub genes associated with MDD in peripheral blood mononuclear cells (PBMCs) (<i>n</i> = 45).
|
31428135 |
2019 |
|
Major Depressive Disorder
|
0.130 |
Biomarker
|
disease |
BEFREE |
The HUB region connects to typical fiber pathways that have been addressed before in therapeutic DBS in major depression.
|
31434867 |
2019 |
|
Major Depressive Disorder
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.
|
30718901 |
2019 |
|
Major Depressive Disorder
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Based on the results of K-M plotter analysis, we investigated the expression profiles of significant hub genes in an array of cancer cell lines using the Cancer Cell Line Encyclopedia database.
|
31733575 |
2020 |
|
Malignant neoplasm of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the DEGs and hub genes identified in the present study may aid in determining the molecular mechanisms associated with PCa carcinogenesis and progression.
|
31746380 |
2020 |
|
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the DEGs and hub genes identified in the present study may aid in determining the molecular mechanisms associated with PCa carcinogenesis and progression.
|
31746380 |
2020 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Based on the results of K-M plotter analysis, we investigated the expression profiles of significant hub genes in an array of cancer cell lines using the Cancer Cell Line Encyclopedia database.
|
31733575 |
2020 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The prognostic values of hub genes in HCC patients were analyzed using The Cancer Genome Atlas (TCGA) database.
|
31746405 |
2020 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
We not only identified the hub target genes of miR-622 <i>in silico</i> but also revealed the regulatory mechanism of miR-622 in breast cancer cell EMT process, viability, and migration <i>in vitro</i> for the first time.
|
31709182 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
We target the phosphorylation-dependent interaction between the hub protein 14-3-3σ and a peptide derived from Estrogen Receptor α (ERα), an important breast cancer target that is negatively regulated by 14-3-3σ.
|
30707565 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
This work used bioinformatics analysis to study this mechanism via gene expression profiles of bufadienolide-like chemicals: (1) Differentially expressed gene identification combined with gene set variation analysis, (2) similar small -molecule detection, (3) tissue-specific co-expression network construction, (4) differentially regulated sub-networks related to breast cancer phenome, (5) differentially regulated sub-networks with potential cardiotoxicity, and (6) hub gene selection and their relation to survival probability.
|
30646630 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Functional annotation analysis of protein-protein interaction network showed FOXM1 as an upexpressed and ESR1 as a downexpressed hub genes are suitable targets as far as antitumor protein therapy is concerned in TN breast cancers.
|
31081218 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
The roles of the genes CASC5, CKAP2L, FAM83D, KIF18B, KIF23, SKA1, GINS1, CDCA5, and MCM6 in breast cancer are unclear, so in order to better reveal the staging of breast cancer markers, it is necessary to study those hub genes.
|
31758680 |
2019 |