ELAVL4, ELAV like RNA binding protein 4, 1996

N. diseases: 31; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.060 AlteredExpression disease BEFREE These results show that the HuD gene is not mutated in lung cancer, including tumors from patients producing anti-HuD antibodies, but HuD expression is an independent marker or determinant of the neuroendocrine differentiation seen in SCLC. 8069866 1994
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.030 GeneticVariation disease BEFREE Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines. 8069866 1994
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.020 GeneticVariation disease BEFREE Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines. 8069866 1994
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.020 GeneticVariation disease BEFREE Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines. 8069866 1994
CUI: C0751912
Disease: Paraneoplastic Encephalomyelitis
Paraneoplastic Encephalomyelitis 		0.010 GeneticVariation disease BEFREE Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines. 8069866 1994
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.060 AlteredExpression disease BEFREE These results revealed that no aberrant alternative splicing occurred in SCLC not associated with PEM/PSN and the expression of HuD gene was not specific for a particular histologic subtype of human lung cancer. 9288629 1997
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.030 AlteredExpression disease BEFREE These results revealed that no aberrant alternative splicing occurred in SCLC not associated with PEM/PSN and the expression of HuD gene was not specific for a particular histologic subtype of human lung cancer. 9288629 1997
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.020 AlteredExpression disease BEFREE These results revealed that no aberrant alternative splicing occurred in SCLC not associated with PEM/PSN and the expression of HuD gene was not specific for a particular histologic subtype of human lung cancer. 9288629 1997
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.020 AlteredExpression disease BEFREE These results revealed that no aberrant alternative splicing occurred in SCLC not associated with PEM/PSN and the expression of HuD gene was not specific for a particular histologic subtype of human lung cancer. 9288629 1997
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism 		0.200 Biomarker disease RGD Neuronal HuD gene encoding a mRNA stability regulator is transcriptionally repressed by thyroid hormone. 12859688 2003
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy 		0.200 Biomarker disease RGD Increased expression and localization of the RNA-binding protein HuD and GAP-43 mRNA to cytoplasmic granules in DRG neurons during nerve regeneration. 12957493 2003
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.060 AlteredExpression disease BEFREE Anti-Hu syndrome is a paraneoplastic neurologic disease seemingly associated with an efficient antitumoral immune response against HuD protein expressed by both small cell lung cancer (SCLC) and neurons. 14512168 2003
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 Biomarker disease LHGDN SNP 2 (located in the first intron of ELAVL4) showed a strong significant association with AAO of PD (P = 0.006), and SNP 5 (a coding SNP in ELAVL4) showed a moderately significant association (P = 0.035). 15827745 2005
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 Biomarker disease BEFREE SNP 2 (located in the first intron of ELAVL4) showed a strong significant association with AAO of PD (P = 0.006), and SNP 5 (a coding SNP in ELAVL4) showed a moderately significant association (P = 0.035). 15827745 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.020 Biomarker disease BEFREE The TH and ELAVL4 assays could detect 1 neuroblastoma cell in 10(6) mononuclear cells. 16384890 2006
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.020 Biomarker disease BEFREE The TH and ELAVL4 assays could detect 1 neuroblastoma cell in 10(6) mononuclear cells. 16384890 2006
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.020 Biomarker disease BEFREE The TH and ELAVL4 assays could detect 1 neuroblastoma cell in 10(6) mononuclear cells. 16384890 2006
CUI: C0278694
Disease: Disseminated neuroblastoma
Disseminated neuroblastoma 		0.010 Biomarker disease BEFREE We used real-time quantitative reverse transcription-PCR (QPCR) of the tyrosine hydroxylase (TH), GD2 synthetase (GALGT), and embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) genes to detect disseminated neuroblastoma cells. 16384890 2006
CUI: C1135161
Disease: Stage 4S neuroblastoma
Stage 4S neuroblastoma 		0.010 Biomarker disease BEFREE We used real-time quantitative reverse transcription-PCR (QPCR) of the tyrosine hydroxylase (TH), GD2 synthetase (GALGT), and embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) genes to detect disseminated neuroblastoma cells. 16384890 2006
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.200 Biomarker disease RGD Coordinated expression of HuD and GAP-43 in hippocampal dentate granule cells during developmental and adult plasticity. 17577668 2007
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 Biomarker disease BEFREE Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect. 17230446 2007
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
PARKINSON DISEASE, LATE-ONSET 		0.010 GeneticVariation disease BEFREE Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age-at-onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. 17230446 2007
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.060 AlteredExpression disease LHGDN Molecular detection of neuron-specific ELAV-like-positive cells in the peripheral blood of patients with small-cell lung cancer. 18607064 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 Biomarker disease LHGDN This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene. 18587682 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 GeneticVariation disease BEFREE This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene. 18587682 2008