In support, recent ERP studies find that, following reward feedback, a larger reward positivity (RewP) is associated with greater vulnerability for bipolar spectrum disorders, whereas a smaller RewP is associated with greater vulnerability for depression.
<b>Methods:</b> We compared ERP waveforms during the processing of emotional faces in a population sample of 58 6-11-year-olds who completed self-reported measures of trait and state anxiety and depression.
The CFS over other methods leads to a good overall performance in most cases, especially when KNN classifier is used for P300 component classification, illustrating that ERP component may be applied as a tool for auxiliary diagnosis of depression.
The reduced task-related ERP response in individuals with depression suggests significant impairments in these individuals in stimulus integration and response functions.
The NET and 5-HT1A polymorphisms appear to have similar effects on hippocampal volume in patients and controls while the 5-HTTLPR polymorphism differentially affects hippocampal volume in the presence of depression.
In conclusion, our results favor the hypothesis that monoaminergic neurotransmission in general and the F528CNET and R219L 5-HT(1A) receptor variants in particular are involved in the pathogenesis of depression.
Since NE signaling contributes to diverse brain functions, we hypothesize that promoter variation within the human NET gene (solute carrier family 6, member 2; SLC6A2) may impact risk for NE-related disorders, including depression, attention deficit hyperactive disorder (ADHD), and autonomic dysfunction.