ELK3, ETS transcription factor ELK3, 2004

N. diseases: 220; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 AlteredExpression group BEFREE SATB2 is frequently and strongly expressed by lower GI tract NETs; we have adopted it as our rectal NET marker. 31233624 2020
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 GeneticVariation group BEFREE Characteristics of 252 patients with bronchopulmonary neuroendocrine tumours treated at the Copenhagen NET Centre of Excellence. 31097087 2019
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE Appendiceal carcinoid (neuroendocrine tumor or NET) is a rare neuroendocrine neoplasm often found incidentally following appendectomy for appendicitis. 31555859 2019
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE Recent updates separate pancreatic neuroendocrine tumors into 2 broad categories: well-differentiated pancreatic neuroendocrine tumors (panNET) and poorly differentiated pancreatic neuroendocrine carcinoma (panNEC), and incorporates a new subcategory of "well-differentiated high-grade NET (G3)" to the well-differentiated NET category. 29912000 2019
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 GeneticVariation group BEFREE The category of grade 3 neuroendocrine tumor (NET G3) was newly introduced in the 2017 World Health Organization (WHO 2017) classification of neuroendocrine neoplasms of the pancreas. 31511024 2019
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE This work presents a first preclinical assessment of this state-of-the-art OV, using a panel of human neuroendocrine tumor/neuroendocrine carcinoma (NET/NEC) cell lines. 31280274 2019
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE Fifty-seven patients with G1, G2, and low G3 NETs with liver metastases were investigated (pancreatic NET (pNET), 24; small bowel, 16; unknown origin (UKO), 9; rectal, 3; lung, 3; and gastric, 2). 29383678 2018
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 GeneticVariation group BEFREE Grade 3 neuroendocrine tumor (NET G3) is a rare new entity that has recently been introduced in the classification of neuroendocrine neoplasms of the pancreas. 29675587 2018
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE TeleNEN as a telemedicine model for neuroendocrine neoplasm management in case of Meckel's diverticulum NET. 29952421 2018
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE The WHO 2017 classification introduces the novel well-differentiated neuroendocrine tumor of high grade (NET G3). 30098710 2018
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE We identified 414 patients with GI-NENs, 250 cases were diagnosed as neuroendocrine tumor G1 (NET G1), 25 as neuroendocrine tumor G2 (NET G2), 53 as neuroendocrine tumor G3 (NET G3), 55 as neuroendocrine carcinoma G3 (NEC G3), and 31 as mixed adenoneuroendocrine carcinoma (MANEC); the overall survival (OS) rate at three years were 94.9%, 91.7%, 74.3%, 62.7% and 38.1%, respectively. 28856815 2018
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE Our data supports the use of specific NET biomarkers based on the site of the primary NET and the presence of hereditary syndrome-associated NET. 28289088 2017
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE ACTH = adrenocorticotropic hormone CT = computed tomography DOTATATE = <sup>68</sup>Ga-DOTA-Tyr<sup>3</sup>-octreotate ECS = ectopic Cushing syndrome FDG = fluorodeoxyglucose MTC = medullary thyroid cancer NET = neuroendocrine tumor PET = positron emission tomography. 28614007 2017
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE At histological examination, 81 patients had a gastric neuroendocrine neoplasia (42 patients had a NET G1 and 33 a NET G2).The median Ki67 index was 2.0 %. 27592118 2017
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas. 29091800 2017
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE Recent studies indicated that PanNEN-G3 includes well-differentiated neuroendocrine tumor with G3 (NET-G3). 28455360 2017
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE ACTH = adrenocorticotropic hormone; BIPSS = bilateral inferior petrosal sinus sampling; CBG = corticosteroid-binding globulin; CD = Cushing disease; CRH = corticotropin-releasing hormone; CS = Cushing syndrome; Dex = dexamethasone; DST = dexamethasone suppression test; EAS = ectopic ACTH syndrome; FDA = U.S. Food & Drug Administration; HDDST = high-dose DST; IPS/P = inferior petrosal sinus to peripheral; MRI = magnetic resonance imaging; NET = neuroendocrine tumor; PET = positron emission tomography; UFC = urinary free cortisol. 28614036 2017
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE GI = gastrointestinal; ICD-9-CM = International Classification of Diseases, 9th Revision, Clinical Modification; NET = neuroendocrine tumor; PMPY = per million person-years; SEER = Surveillance, Epidemiology, and End Results. 28704096 2017
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 AlteredExpression group BEFREE DMSG = DutchMEN1 Study Group; D-NET = duodenal neuroendocrine tumor; DP-NET = duodenopancreatic neuroendocrine tumor; HPF = high-power field; Ki67 LI = Ki67 labeling index; MEN1 = multiple endocrine neoplasia type 1; NET = neuroendocrine tumor; OS = overall survival; P-NET = pancreatic neuroendocrine tumor; PPI = proton pump inhibitor; ULN = upper limit of normal; WHO = World Health Organization. 28225311 2017
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE Neuroendocrine tumors of the small intestine (SI-NETs) exhibit an increasing incidence and high mortality rate. 27222126 2017
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE Clinicopathologic correlation was made among poorly differentiated neuroendocrine carcinomas (NECs/poorly differentiated histology and Ki-67 >20%) and pancreatic neuroendocrine tumours (PanNETs/Ki67 ⩽20%) and non-pancreatic neuroendocrine tumours (NP-NETs/Ki67 ⩽20%). 27482646 2016
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 Biomarker group BEFREE In order to evaluate biomarker precision and identify if combinatorial blood molecular markers and imaging could provide added diagnostic value, we assessed the concordance between (68)Ga-somatostatin analog (SSA) positron emission tomography (PET), circulating NET gene transcripts (NETest), chromogranin A (CgA), and Ki-67 in NETs. 25947577 2015
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.100 GeneticVariation group BEFREE IL-2 -330 T/G SNP and serum values-potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs). 20049409 2010