|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
BEFREE |
Insufficient elastin synthesis leads to vascular complications and arterial hypertension in children with Williams-Beuren syndrome.
|
31138170 |
2019 |
|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
BEFREE |
This study demonstrates the pro-stiffening effect of salt in addition to hypertension; it shows that only the abdominal aorta presents a specific pressure-independent stiffening, in which elastin disarray is likely a key mechanism.
|
29886482 |
2018 |
|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
BEFREE |
Using the elastin heterozygous (Eln+/-) mouse model, we tested whether renal dysfunction due to elastin deficiency occurs independently of and precedes the development of hypertension.
|
28754555 |
2017 |
|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
BEFREE |
Elastin deficiency in aging and disease is linked to increased vascular stiffness and hypertension, which are both associated with chronic kidney disease.Owens et al. show that alterations in renal arteries and kidney structure precede or are independent of hypertension in elastin haploinsufficient mice.
|
29055422 |
2017 |
|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
BEFREE |
We identify LOX as a novel source of vascular reactive oxygen species and a new pathway involved in vascular stiffness and elastin remodeling in hypertension.
|
28010122 |
2017 |
|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
BEFREE |
The autopsy disclosed pulmonary vascular dysplasia affecting small arteries and veins associated with abnormal elastin distribution in tortuous dilated arteries and veins, with nonuniform wall thickness and semiobstructive lesions at artery branch points typical of early pulmonary hypertensive vascular disease.
|
25133308 |
2015 |
|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
BEFREE |
Elastin insufficiency leads to the cardiovascular hallmarks of this condition, namely focal stenosis and hypertension.
|
24126171 |
2014 |
|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
BEFREE |
Elastin in large artery stiffness and hypertension.
|
22290157 |
2012 |
|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
BEFREE |
A hallmark feature of Williams-Beuren Syndrome (WBS) is a generalized arteriopathy due to elastin deficiency, presenting as stenoses of medium and large arteries and leading to hypertension and other cardiovascular complications.
|
22319452 |
2012 |
|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
BEFREE |
Bioinformatic analysis of the quantitative trait locus peaks revealed several interesting candidates, including Ren1, Ncf1, and Nos1; genes whose functions are unrelated to elastic fiber assembly, but whose effects may synergize with elastin insufficiency to predispose to hypertension and stiffer blood vessels.
|
22049077 |
2011 |
|
Hypertensive disease
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Physiological and morphological comparisons correlate elastin haploinsufficiency with increased blood pressure and vessel length and tortuosity in dHet mice, and fibrillin-1 haploinsufficiency with increased aortic diameter in the same mutant animals.
|
19850904 |
2009 |
|
Hypertensive disease
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Human elastin protein interacts with mouse elastin to form functional elastic fibers and when expressed in the elastin haploinsufficient background reverses the hypertension and cardiovascular changes associated with that phenotype.
|
17626896 |
2007 |
|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
CTD_human |
The aims of this study were: 1) to determine serum cobalt concentrations in children with hypertension; and 2) to study the correlation between serum cobalt and some biological markers of the extracellular matrix of the vascular wall, i.e., anti-elastin and anti-collagen type IV antibodies.
|
17039479 |
2007 |
|
Hypertensive disease
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Haploinsufficiency at the elastin gene is known to lead to the vascular stenoses in WBS and is also thought to predispose to hypertension, present in approximately 50% of patients.
|
16532385 |
2006 |
|
Hypertensive disease
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Associations of the ELN 3'-untranslated region (-/A) polymorphism with hypertension and pulse wave velocity were reconfirmed in another set of the study population.
|
16982955 |
2006 |
|
Hypertensive disease
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Systemic vascular alterations caused by deletion of the elastin gene may occur early in individuals with Williams-Beuren syndrome, leading to the clinical manifestation of systemic arterial hypertension refractory to drug treatment.
|
12219191 |
2002 |
|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
BEFREE |
Elastin synthesis was studied in blood vessels from newborn calves with severe pulmonary hypertension induced by alveolar hypoxia in order to investigate the cellular stimuli that elicit changes in pulmonary arterial connective tissue production.
|
3603030 |
1987 |
|
Hypertensive disease
|
0.500 |
Biomarker
|
group |
HPO |
|
|
|