|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Systemic alterations to the synthesis and degradation of elastin may be important to our understanding of disease phenotypes in chronic obstructive pulmonary disease.
|
31234847 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim was to assess vitamin K status in COPD as well as associations between vitamin K status, elastin degradation, lung function parameters and mortality.
|
31357639 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Baseline plasma concentration of anti-elastin antibodies and elastin-degrading enzymes (eg, matrix metalloproteinase-9, and -12, and neutrophil elastase) were measured in the same cohort. elastin fragment-specific CD 4<sup>+</sup> T cell expression of interferon-γ, and anti-elastin antibodies were dependent on history of smoking in TAA / TAD patients but were independent of chronic obstructive pulmonary disease.
|
30957625 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort.
|
30858579 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Excessive genesis of soluble elastin peptides (EP) is a key factor in the pathophysiology of COPD.
|
30675803 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Serological levels of both elastin fragments were significantly elevated in patients with COPD compared to healthy controls.
|
30017196 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
For this reason, the UPEXS has focused on disorders that involve the extracellular matrix in general and elastin specifically, such as pelvic organ prolapse, atrial fibrillation, inguinal hernias, and chronic obstructive pulmonary disease.
|
29965901 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Such an agent is hyaluronan aerosol, which is deficient in post mortem lungs with chronic obstructive pulmonary disease and has been shown to block elastin degradation, possibly by a barrier function.
|
29461896 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to explore Th1/Th2 cytokines ratio differences in patients in different stages of COPD and to confirm the hypothesis that elastin exposure might serve as an antigen to initiate the stimulation of CD4 <sup>+</sup> Th1-CXCR3 immune inflammation pathway.
|
29752829 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chronic obstructive pulmonary disease (COPD) and particularly emphysema are characterized by stiffness of the aorta, due in part to accelerated elastin degradation in the lungs and aorta.
|
28488348 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Areas covered: We propose inhalation therapy to induce repair of damaged pulmonary elastin fibers by stimulating tropoelastin synthesis, assembly and crosslinking in order to improve lung function in patients with COPD.
|
29600734 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
A novel therapy for COPD involving the use of aerosolized hyaluronan (HA) was tested on a small cohort of COPD patients to determine both its safety and efficacy in reducing levels of desmosine and isodesmosine (DID), biomarkers for elastin degradation.
|
29075107 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Desmosine and isodesmosine (DID) are unique elastin crosslinks that may serve as biomarkers for elastic fiber degradation in chronic obstructive pulmonary disease.
|
27761647 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Versican siRNA treatment reduced versican expression and secretion by pulmonary fibroblasts from both COPD and non-COPD patients (<i>P</i><0.01) and significantly increased deposition of insoluble elastin in the COPD cell cultures (<i>P</i><0.05).
|
28138236 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Chronic obstructive pulmonary disease and emphysema are associated with increased elastin peptides (EP) production because of excessive breakdown of lung connective tissue.
|
28572155 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
I hypothesize that inhibiting elastin calcification by means of magnesium supplementation might counteract both vascular calcification and elastin degradation in COPD.
|
28915968 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest that type VI collagen turnover and elastin degradation by neutrophil elastase are associated with COPD-induced inflammation (eosinophil-bronchitis) and emphysema.
|
28103932 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated higher ELN gene expression in COPD lung tissue and similar trends for FBLN5 and MFAP4, and negative correlations with lung function.
|
24990664 |
2015 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Lung tissue sections of chronic models for COPD, either induced by exposure to cigarette smoke, chronic intratracheal lipopolysaccharide instillation, or local tumor necrosis factor (TNF) expression [surfactant protein C (SPC)-TNFα mice], were stained for elastin, collagen, and hyaluronan.
|
25106431 |
2014 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Versican inhibits assembly of tropoelastin into insoluble elastin and we conclude that the pro-inflammatory phenotype of COPD fibroblasts is not compatible with repair of elastic fibres.
|
22117690 |
2012 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Patients with COPD have increased skin elastin degradation compared with controls, which is related to emphysema severity and arterial stiffness.
|
22374923 |
2012 |
|
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a multivariable logistic regression analysis adjusted for traditional cardiovascular risk factors and chronic obstructive pulmonary disease, -1306C/T MMP2 (odds ratios [OR] = 0.55 [95% confidence interval, CI .34-.85], P < .007) and G1355A ELN (OR = 0.64 ([95% CI .41-.99], P = .046) polymorphisms resulted in independent protective factors for abdominal aortic aneurysm (AAA), whereas 5A/6A MMP3 (OR = 1.82 [95% CI 1.04-3.12], P = .034) and -77 A/G MMP-13 (OR = 2.14 [95% CI 1.18-3.86], P = .012) polymorphisms resulted in independent risk factors for AAA.
|
22094117 |
2012 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that COPD lung fibroblasts have a significantly decreased response to TGF-β1 in terms of proliferation and elastin production.
|
21539942 |
2011 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, using ELISA from elastin peptides, we verified that 43% of the patients with severe early onset of chronic obstructive pulmonary disease tested positive for IgG to elastin in their serum compared to healthy controls.
|
21573156 |
2011 |
|
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We postulate that hemizygosity at the elastin gene locus may increase susceptibility towards the development of COPD and emphysema in subjects with WBS.
|
20186780 |
2010 |