MUC20, mucin 20, cell surface associated, 200958

N. diseases: 20; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 Biomarker group BEFREE In intraperitoneal, subcutaneous, and orthotopic injection models, MUC20 knockdown decreased tumour growth in immunodeficient mice. 29993037 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.030 Biomarker phenotype BEFREE MUC20 knockdown with siRNA decreased cell viability, as well as migration and invasion induced by PSCs in HPAC and HPAF-II cells. 29993037 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 AlteredExpression group BEFREE MUC20 expression was assessed in tissue microarray and tumor specimens of EOC patients by immunohistochemistry. 26616226 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 AlteredExpression group BEFREE IHC was conducted to examine the expression of selected target markers MUC4, MUC13, and MUC20 in 186 ESCC resection samples and the relationships between their expression and tumor regression grade was analyzed. 26673820 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.030 AlteredExpression phenotype BEFREE MUC20 overexpression significantly enhanced EOC cell migration and invasion, but not viability. 26616226 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.030 AlteredExpression phenotype BEFREE Moreover, MUC20 overexpression enhanced EGF-mediated migration and invasion, suggesting a critical role of EGFR in MUC20-mediated effects. 23262208 2013
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.020 Biomarker disease BEFREE This study was performed to explore the effect of MUC20 in endometrial cancer (EC). 30784116 2019
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.020 Biomarker disease BEFREE This study was performed to explore the effect of MUC20 in endometrial cancer (EC). 30784116 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.020 AlteredExpression phenotype BEFREE High expression of MUC20 drives tumorigenesis and predicts poor survival in endometrial cancer. 30784116 2019
Squamous cell carcinoma of esophagus
0.020 Biomarker disease BEFREE IHC was conducted to examine the expression of selected target markers MUC4, MUC13, and MUC20 in 186 ESCC resection samples and the relationships between their expression and tumor regression grade was analyzed. 26673820 2016
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.020 Biomarker phenotype BEFREE Mucin (MUC) 20 has recently been implicated to play a role in human carcinogenesis. 26616226 2016
Squamous cell carcinoma of esophagus
0.020 AlteredExpression disease BEFREE The expression of MUC13 and MUC20 in ESCC mainly occurred in the cytoplasm. 26323930 2015
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.020 AlteredExpression disease BEFREE High levels of MUC20 expression in EC tumors were correlated with an unfavorable histologic subtype. 23262208 2013
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.020 AlteredExpression disease BEFREE High levels of MUC20 expression in EC tumors were correlated with an unfavorable histologic subtype. 23262208 2013
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.020 GeneticVariation disease BEFREE The frequencies of the alleles and genotypes of MUC20 VNTR polymorphisms did not differ between patients with IgAN and healthy controls. 16508246 2006
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.020 Biomarker disease BEFREE These characteristics suggest that the production of MUC20 is correlated with development and progression of IgAN and other renal injuries. 14565953 2004
Secondary malignant neoplasm of lymph node
0.010 AlteredExpression disease BEFREE MUC20 high expression was associated with age, histology, positive peritoneal cytology, advanced stage, and lymph node metastasis (P < 0.05). 30784116 2019
CUI: C0021051
Disease: Immunologic Deficiency Syndromes
Immunologic Deficiency Syndromes
0.010 Biomarker group BEFREE In intraperitoneal, subcutaneous, and orthotopic injection models, MUC20 knockdown decreased tumour growth in immunodeficient mice. 29993037 2018
CUI: C1335302
Disease: Pancreatic Ductal Adenocarcinoma
Pancreatic Ductal Adenocarcinoma
0.010 Biomarker disease BEFREE Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway. 29993037 2018
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
0.010 AlteredExpression disease BEFREE In this study, immunohistochemical staining demonstrated that high MUC20 expression correlated with poor progression-free survival and high local recurrence rate of PDAC patients (n = 61). 29993037 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker phenotype BEFREE Our results suggest that MUC20 enhances aggressive behaviors of EOC cells by activating integrin β1 signaling and provide novel insights into the role of MUC20 in ovarian cancer metastasis. 26616226 2016
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.010 AlteredExpression disease BEFREE Analysis using the Gene Expression Omnibus public microarray database indicated higher DUSP28, MUC1, MUC4, MUC5B, MUC16 and MUC20 messenger RNA (mRNA) levels in pancreatic cancers compared with normal pancreas tissues. 27230679 2016
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.010 AlteredExpression disease BEFREE MUC20 overexpression significantly enhanced EOC cell migration and invasion, but not viability. 26616226 2016
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial
0.010 AlteredExpression disease BEFREE MUC20 overexpression significantly enhanced EOC cell migration and invasion, but not viability. 26616226 2016
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.010 Biomarker disease BEFREE Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis. 26770020 2015