|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor tissues derived from J cells exhibited high expression levels of HIF-2α and EGFR compared to the slow developing and small K cell derived tumors.
|
22768190 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.
|
25417700 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor infiltrating mast cells determine oncogenic HIF-2α-conferred immune evasion in clear cell renal cell carcinoma.
|
30758643 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HIF-2α and Beclin 1 were associated with histological grade and Musculoskeletal Tumor Society stage.
|
21327823 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HIF2α is a potent oncogenic stimulus, but its role in Kras-induced pancreatic neoplasia has not been discerned.
|
23749643 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HIF-2α siRNA inhibited the proliferation and promoted the apoptosis of HCC cells in vitro, and synergized with sorafenib to suppress the growth of HCC tumors in vivo.
|
24486412 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HIF-2α and MMP-9 were significantly correlated with primary tumor size (P = 0.0065 and P = 0.036, respectively) and invasion depth (P = 0.012 and P = 0.008, respectively).
|
25730079 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Hypoxia-inducible factor-2α (HIF-2α) plays an important role in increasing cancer progression and distant metastasis in a variety of tumour types.
|
28544376 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HIF-2α expression may be associated with the carcinogenesis of CRC, which is higher in males than in females, negatively linked to tumor differentiation, and correlated with a worse DFS of CRC.
|
30021192 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HIF2α was consistently present in OS patients and dependent on tumor site and clinical stage.
|
30836200 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A recurrent variant, c.1121G>A (p.Gly374Glu), found in four of the eight individuals triggered accumulation of 2-hydroxyglutarate, both in tumors and in a heterologous cell-based assay designed to functionally evaluate DLST variants. p.Gly374Glu-DLST tumors exhibited loss of heterozygosity, and their methylation and expression profiles are similar to those of EPAS1-mutated PPGLs; this similarity suggests a link between DLST disruption and pseudohypoxia.
|
30929736 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A small-molecule inhibitor of HIF2α activity diminishes the tumor response to AZA+RA treatment, indicating that the increase in HIF2α levels is a key component in tumor response to AZA+RA.
|
28696319 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Aberrations on chromosome 3p are associated with inactivation of the tumor suppressor gene von-Hippel Lindau (VHL), which activates the hypoxia-inducible factors HIF1α and HIF2α.
|
22094876 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Adaptation to hypoxia is mediated by hypoxia-inducible factors (HIFs), including HIF-1α and HIF-2α, which regulate genes promoting angiogenesis, increased tumor growth or metastasis.
|
28217462 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additionally, osteosarcoma patients with HIF-2α mRNA and/or HIF2PUT over-expression more frequently had large tumor size (all P<0.05), advanced clinical stage (all P<0.01) and positive distant metastasis (all P<0.01).
|
27623205 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although HIF2α is an oncogene in ccRCC, some of its targets might have tumor suppressive activity.
|
21725364 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
An E0771 allograft breast tumor model revealed faster tumor growth in myeloid HIF-2α knockout (HIF-2α<sup>LysM-/-</sup> ) compared with wildtype (wt) mice.
|
31436357 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Because tumor hypoxia is related to aggressive tumor behavior and the hypoxic adaptation of SCLC is poorly documented, we stained SCLC tumors arranged in a tissue microarray for hypoxia-inducible factor (HIF)-1α and HIF-2α proteins.
|
22115707 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both HIF-1α and HIF-2α expression levels have been shown to correlate to patient outcome in various tumor forms and in neuroblastoma, a solid childhood tumor of the sympathetic nervous system, in particular, HIF-2α marks a subpopulation of immature neural crest-like perivascularly located cells and associates with aggressive disease and distant metastasis.
|
29032465 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By contrast, transient expression of HIF1α(PP) in U-87 MG cells or constitutive expression of HIF1α(PP) but not HIF2α(PP) in a patient-derived glioma sphere culture inhibited tumor growth and spread.
|
25893706 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC and bears a significantly high frequency of hypoxia-inducible factor 2α (HIF-2α) because of von Hippel-Lindau (VHL) tumor suppressor gene mutations.
|
31541711 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Collectively, the differentially regulated proteome characterized by this study can potentially guide translational research specifically aimed at effective clinical interventions for advanced VHL-mutant, HIF2α-over-expressing tumors.
|
23940778 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Consistent with the known role of the tumor suppressor ZEB2 in the cancer-associated epithelial to mesenchymal transition (EMT), in situ hybridization reveals that the intronic regions deriving from ZEB2 as well as those from RFX2 and EPAS1 are down-regulated in cells of epithelial morphology, suggesting that these regions may be important for maintaining normal epithelial cell morphology.
|
25798919 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Conversely, polymorphisms at the HIF-2α gene locus predispose to the development of ccRCCs, and HIF-2α promotes tumor growth.
|
26298207 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Deletion of endothelial HIF-2α rendered the lung environment more vulnerable to tumour cell seeding and growth.
|
31308473 |
2019 |