Erythrocytosis, Familial, 4
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Erythrocytosis, Familial, 4
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
Hematocrit increased
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Hemoglobin increased
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Renal Cell Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
EPAS1 was detected in all of the RCC cell lines examined.
|
11301389 |
2001 |
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
EPAS1 was detected in all of the RCC cell lines examined.
|
11301389 |
2001 |
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that components of the hypoxia response pathway, including HIF-1 alpha and HIF-2 alpha, are important cofactors in the regulation of VEGF in bladder cancer and are therapeutic targets in this disease.
|
11350893 |
2001 |
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that components of the hypoxia response pathway, including HIF-1 alpha and HIF-2 alpha, are important cofactors in the regulation of VEGF in bladder cancer and are therapeutic targets in this disease.
|
11350893 |
2001 |
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that components of the hypoxia response pathway, including HIF-1 alpha and HIF-2 alpha, are important cofactors in the regulation of VEGF in bladder cancer and are therapeutic targets in this disease.
|
11350893 |
2001 |
Pheochromocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Real-time quantitative reverse transcriptase (RT)-PCR measurements confirmed that vascular endothelial growth factor and endothelial PAS domain protein 1 mRNA levels were significantly higher (three- and sixfold, respectively) than those observed in three sporadic benign pheochromocytomas.
|
11605159 |
2001 |
Adrenal Gland Pheochromocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Real-time quantitative reverse transcriptase (RT)-PCR measurements confirmed that vascular endothelial growth factor and endothelial PAS domain protein 1 mRNA levels were significantly higher (three- and sixfold, respectively) than those observed in three sporadic benign pheochromocytomas.
|
11605159 |
2001 |
Adenocarcinoma of lung (disorder)
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We showed that EPAS1, but not HIF-1alpha, is abundantly expressed in human lung adenocarcinoma A549 cells.
|
11751212 |
2002 |
Hyaline Membrane Disease
|
0.200 |
Biomarker
|
disease |
MGD |
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice.
|
12053176 |
2002 |
Adenocarcinoma
|
0.060 |
AlteredExpression
|
group |
LHGDN |
Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma.
|
12209691 |
2002 |
Renal Cell Carcinoma
|
0.700 |
Biomarker
|
disease |
RGD |
Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.
|
12750296 |
2003 |
Hyaline Membrane Disease
|
0.200 |
Biomarker
|
disease |
MGD |
Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.
|
12750401 |
2003 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis.
|
12823854 |
2003 |
Rheumatoid Arthritis
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis.
|
12823854 |
2003 |
Infarction
|
0.200 |
Biomarker
|
phenotype |
RGD |
Cellular responses to hypoxia after renal segmental infarction.
|
12911537 |
2003 |
melanoma
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin.
|
14512791 |
2003 |
Anoxia
|
0.060 |
Biomarker
|
phenotype |
LHGDN |
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha.
|
14744852 |
2004 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
HIF-2alpha/EPAS1 is expressed in most of HCC with capsular infiltration and portal vein invasion, which indicates a possible role of HIF-2alpha/EPAS1 in HCC metastasis.
|
14966910 |
2004 |
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we sought to determine whether PAI-1 gene expression is directly regulated by EPAS1 in cancer cells because activities of proteases and their inhibitors are tightly regulated for tumor invasion.
|
15039136 |
2004 |
Adenocarcinoma
|
0.060 |
Biomarker
|
group |
BEFREE |
The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells.
|
15039136 |
2004 |
Renal Cell Carcinoma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Effect of radiation and ibuprofen on normoxic renal carcinoma cells overexpressing hypoxia-inducible factors by loss of von Hippel-Lindau tumor suppressor gene function.
|
15217953 |
2004 |