Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study highlights adipocyte HIF-2α as a putative drug target against atherosclerosis.
|
31668872 |
2019 |
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study highlights adipocyte HIF-2α as a putative drug target against atherosclerosis.
|
31668872 |
2019 |
Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data confirm our previous finding that epithelial HIF-2α mediates inflammatory response and demonstrates that activation of HIF-2α is sufficient to exacerbate colitis.<b>NEW & NOTEWORTHY</b> Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestinal tract.
|
31241981 |
2019 |
Dermatitis, Atopic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, PHD and HIF-2α could be a new strategy for treatment of atopic dermatitis and psoriasis.
|
31682627 |
2019 |
Eczema
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, PHD and HIF-2α could be a new strategy for treatment of atopic dermatitis and psoriasis.
|
31682627 |
2019 |
Kidney Failure, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, hippocampal EPO, EPOR, p-EPOR (Tyr485), STAT5, AKT1, and HIF-2α, as well as the number of astrocytes in CA1 zone of hippocampus were also decreased in CRF mice, while YGY extract prominently promoted the expressions of these proteins and increased the number of astrocytes.
|
31055001 |
2019 |
Multiple Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our aim was to evaluate the LincR-Gng2-5' and LincR-Epas1-3'AS fold change in blood of MS patients versus healthy controls and correlate it with disease severity, assessed based on Expanded Disability Status Scale (EDSS).<b>Material and Methods:</b> Sixty MS patients 42 relapsing remitting (RR, RRMS), 18 Secondary progressive (SP, SPMS) and sixty controls (age-matched and sex-matched) were studied.
|
31790618 |
2019 |
Osteopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
HIF-2α deficiency alleviated ovariectomy-induced bone loss in mice, and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKL-mediated osteoclastogenesis.
|
31098335 |
2019 |
Kaposi Sarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results show that the KSHV ORF34 protein is involved in the KSHV life cycle by regulating the expression of HIF-1α and HIF-2α proteins.<b>IMPORTANCE</b> Hypoxia inducible factor 1α (HIF-1α) and HIF-2α are transcription factors which play important roles in the Kaposi's sarcoma-associated herpesvirus (KSHV) latent and lytic gene replication.
|
31189709 |
2019 |
Squamous cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mega-analysis revealed that three LA-associated genes, such as solute carrier family 2 member 1 (SLC2A1), endothelial PAS domain protein 1 (EPAS1) and cyclin-dependent kinase 4 (CDK4), were significantly associated with LSCC (P<1.60×10<sup>-8</sup>), with multiple potential pathways identified by functional pathway analysis, which were further validated by co-expression analysis.
|
31516564 |
2019 |
Intervertebral Disc Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
An in vivo rabbit disc degeneration model was established to demonstrate that HIF-2α plays a critical role in disc degeneration.
|
31251999 |
2019 |
Iron deficiency anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate a hetero-tissue crosstalk mechanism, whereby hepatic hepcidin regulated intestinal HIF-2α in iron deficiency, anemia, and iron overload.
|
30352047 |
2019 |
Caffeine related disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Caffeine and hyperoxia in itself upregulate HIF-2α and vascular endothelial growth factor gene expression.
|
31362742 |
2019 |
Gastrointestinal Stromal Tumors
|
0.010 |
Biomarker
|
group |
BEFREE |
The xenograft tumor data further confirmed the regulated effect of HIF-1α and HIF-2α on FoxM1, and demonstrated that the simultaneous downregulation of both HIF-1α and HIF-2α inhibited GIST tumor growth.
|
29948390 |
2019 |
Transient erythroblastopenia of childhood
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We monitored BNIP3 expression in the testosterone-induced TECs injury model after treatment with hypoxia inducible factor 1α (HIF-1α) and/or hypoxia inducible factor 2α (HIF-2α) inhibitors to determine the upstream protein regulating BNIP3 expression.
|
30819186 |
2019 |
Age related macular degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study provides the groundwork necessary to establish safety profiles for strategies aiming at antagonizing HIF1A and HIF2A function in cone photoreceptors for the treatment of retinal degenerative diseases that involve a hypoxic component such as AMD.
|
31695081 |
2019 |
Impaired glucose tolerance
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
HIF2α knockout in POMC neurons led to age-dependent excess weight gain and fat increase, a phenotype that was associated with a mild degree of glucose intolerance and insulin resistance.
|
30709906 |
2019 |
Microcytic hypochromic anemia (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mice with targeted deletion of <i>Ncoa4</i> specifically in the erythroid compartment developed a pronounced anemia in the immediate postnatal stage, a mild hypochromic microcytic anemia at adult stages, and were more sensitive to hemolysis with higher requirements for the Hif2a-erythropoietin axis and extramedullary erythropoiesis during recovery.
|
30630985 |
2019 |
Carcinoma breast stage IV
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our study has uncovered high FOXA1-induced enhancer reprogramming and HIF-2α-dependent transcriptional programs as vulnerable targets for treating endocrine-resistant and metastatic breast cancer.
|
31826955 |
2019 |
Malignant Childhood Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cellular levels of the HIF-2α transcription factor subunit influence the histopathology and clinical outcome of neuroblastoma, a malignant childhood tumor of the sympathetic ganglia.
|
30468780 |
2019 |
Inflammatory disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
These data confirm our previous finding that epithelial HIF-2α mediates inflammatory response and demonstrates that activation of HIF-2α is sufficient to exacerbate colitis.<b>NEW & NOTEWORTHY</b> Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestinal tract.
|
31241981 |
2019 |
Tumor Immunity
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
HIF-2α contributed to evasion of anti-tumor immunity via SCF secretion and subsequent recruitment of mast cells in ccRCC patients.
|
30758643 |
2019 |
OVERLAP CONNECTIVE TISSUE DISEASE
|
0.010 |
Biomarker
|
disease |
BEFREE |
Oxygen sensing in osteocytes can confer a high bone mass phenotype in murine models; common and unique targets of HIF-1α and HIF-2α and lineage-specific deletion of oxygen sensing machinery suggest differentia utilization and requirement of HIF-α proteins in the differentiation from mesenchymal stem cell to osteoblast to osteocyte; oxygen-dependent but HIF-α-independent signaling may contribute to observed skeletal phenotypes.
|
30725321 |
2019 |
HER2-positive carcinoma of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HIF-2α expression is frequently higher in HER2-overexpressing tumours and is associated with worse disease-specific survival in HER2-positive breast cancer patients.
|
30670058 |
2019 |
Malignant tumor of cervix
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the role of miRNAs in the regulation of HIF-2α expression in cervical cancer under hypoxic conditions. miRNAs regulating HIF-2α expression were predicted using TargetScan and miRanda and were determined in cervical cancer under hypoxic conditions by qRT-PCR.
|
29321085 |
2018 |