|
Renal Cell Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
HIF2A germline-mutation-induced polycythemia in a patient with VHL-associated renal-cell carcinoma.
|
29172931 |
2017 |
|
Renal Cell Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Knockdowns of TRAIL averted apoptotic cell death caused by HIF2-alpha inhibition in starvation-resistant RCCs.
|
29796174 |
2018 |
|
Renal Cell Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In determining the critical functions for HIF2α expression in RCC cells, the NADPH oxidase NOX4 has been identified, but the pathogenic contributions of NOX4 to RCC have not been evaluated directly.
|
24755467 |
2014 |
|
Renal Cell Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We found that the anti-angiogenic TKI sunitinib disrupted the balance between HIF-1α and HIF-2α in RCCs and led to a protective effect on HUVECs against sunitinib treatment when cultured with conditioned medium.
|
28572533 |
2017 |
|
Renal Cell Carcinoma
|
0.700 |
Biomarker
|
disease |
CTD_human |
Two correlated variants (r² = 0.99 in controls), rs11894252 (P = 1.8 × 10⁻⁸) and rs7579899 (P = 2.3 × 10⁻⁹), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC.
|
21131975 |
2011 |
|
Renal Cell Carcinoma
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23.
|
22010048 |
2012 |
|
Renal Cell Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In follow-up of a recent genome-wide association study (GWAS) that identified a locus in chromosome 2p21 associated with risk for renal cell carcinoma (RCC), we conducted a fine mapping analysis of a 120 kb region that includes EPAS1.
|
22113997 |
2012 |
|
Renal Cell Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion.
|
21695080 |
2011 |
|
Renal Cell Carcinoma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha.
|
16920734 |
2007 |
|
Renal Cell Carcinoma
|
0.700 |
Biomarker
|
disease |
RGD |
Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.
|
12750296 |
2003 |
|
Renal Cell Carcinoma
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Two correlated variants (r² = 0.99 in controls), rs11894252 (P = 1.8 × 10⁻⁸) and rs7579899 (P = 2.3 × 10⁻⁹), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC.
|
21131975 |
2011 |
|
Renal Cell Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The authors observed evidence of interactions between PhIP and RCC susceptibility variants in 2 genes: inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) (rs718314; multiplicative P for interaction = .03 and additive P for interaction =.002) and endothelial PAS domain-containing protein 1 (EPAS1) (rs7579899; additive P for interaction =.06).
|
26551148 |
2016 |
|
Renal Cell Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma.
|
15592504 |
2005 |
|
Renal Cell Carcinoma
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
|
28598434 |
2017 |
|
Renal Cell Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
To investigate the oncolytic efficacy of a highly virulent (velogenic) Newcastle disease virus (NDV) in the presence or absence of HIF-2α, renal cell carcinoma (RCC) cell lines with defective or reconstituted wild-type (wt) von Hippel-Lindau (VHL) activity were used.
|
23506478 |
2013 |
|
Renal Cell Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Together, these results may provide us a new therapeutic approach via targeting this newly identified signal from LncRNA-SARCC to AR-mediated HIF-2α/C-MYC signals against RCC progression.
|
26973243 |
2016 |
|
Renal Cell Carcinoma
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer.
|
25826619 |
2015 |