Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE Two recent independent studies published in <i>Nature</i> show robust responses of clear cell renal cell carcinoma (ccRCC) cell lines, preclinical ccRCC xenograft models and, remarkably, a patient with progressive ccRCC despite receiving multiple lines of treatment, to the long-awaited, recently developed inhibitors of hypoxia-inducible factor 2-alpha (HIF2α). 28667082 2018
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 AlteredExpression disease BEFREE Our results indicate that downregulation of Dicer in VHL-deficient ccRCCs contributes to high levels of HIF-2α and a malignant phenotype, which suggests Dicer could be a useful therapeutic target for managing this disease. 26943772 2017
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma. 25829424 2016
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 AlteredExpression disease BEFREE We show here that the ccRCC cell lines RCC4 and RCC10, which express mutant versions of VHL, have reduced HIF1α expression in hypoxia, whereas HIF2α expression is increased or not affected. 25915846 2016
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE This study indicates that autophagy has an anticancer role in ccRCC tumorigenesis, and suggests that constitutive autophagic degradation of HIF2α is a novel tumor suppression mechanism. 24998849 2015
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE This indicates that current understanding of the exact roles of HIF1α and HIF2α is incomplete and that further research is required to determine the diverse roles of HIF1α and HIF2α in ccRCC. 24916472 2015
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE CPT demonstrated striking inhibition of both HIF-1α and HIF-2α accumulation in von Hippel-Lindau (VHL)-defective ccRCC cells, but surprisingly failed to inhibit protein levels of HIF-2α-dependent target genes (VEGF, PAI-1, ET-1, cyclin D1). 24136229 2014
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 AlteredExpression disease BEFREE In this issue of Cancer Discovery, Mathew and colleagues report that miR-30c-2-3p and miR-30a-3p downregulation in ccRCC promotes increased expression of HIF2α. 24402943 2014
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients. 23378636 2013
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE Targeting HIF2α translation with Tempol in VHL-deficient clear cell renal cell carcinoma. 23178531 2013
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE Although HIF2α is an oncogene in ccRCC, some of its targets might have tumor suppressive activity. 21725364 2012
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease BEFREE Further exploration of 8q gain, 14q loss, MYC, HIF1A and EPAS1 (HIF2α) as molecular markers of tumor behavior and prognosis could aid in personalizing medicine for patients with clear-cell renal cell carcinoma. 21725288 2012
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 AlteredExpression disease BEFREE HIF-1α, HIF-2α and CAIX were up-regulated in 88.2% (15/17), 100% (17/17) and 88.2% (15/17) of tumors respectively and their expression is independent of VHL status. hnRNP A2/B1 and osteopontin expression was variable in CCRCCs and had no association with VHL genetic status. 21547579 2011
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 Biomarker disease CTD_human Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. 21131975 2011