EPHA1, EPH receptor A1, 2041

N. diseases: 119; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.060 Biomarker phenotype BEFREE In addition to modulating cell proliferation and migration, EPH receptors are also involved in tumor progression. 25331796 2015
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.060 Biomarker phenotype BEFREE As EFNA5 down-regulation is a consistent finding in chondrosarcomas, we presume that it represents another essential alteration in tumorigenesis and tumor progression associated with cell adhesion, in addition to a multitude of other partially unknown biologic functions mediated by bidirectional ephrin/Eph receptor signaling and cross talk. 19695673 2009
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.060 AlteredExpression phenotype BEFREE High expression of Eph receptors in a wide variety of human tumors indicates some roles in tumor progression, which makes these proteins potential targets for anticancer therapy. 18790757 2008
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.060 AlteredExpression phenotype BEFREE Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. 18507018 2008
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.060 AlteredExpression phenotype BEFREE These findings identify a novel Eph receptor signalling pathway with tumour-suppressor activity and predict that therapeutic intervention to activate EphB4 signalling will inhibit tumour progression. 16862147 2006
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.060 AlteredExpression phenotype BEFREE EPH-A2, or ECK (a receptor for ephrin-A1), is ectopically expressed in most melanoma cell lines; the pathology where this expression is first manifested and the possible role of the receptor in tumor progression are unknown. 10502726 1999