EPO, erythropoietin, 2056

N. diseases: 646; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005283
Disease: beta Thalassemia
beta Thalassemia
0.340 Biomarker disease BEFREE Recent studies established that hypoxia and/or hypoxia-induced erythropoietin are not direct regulators of hepcidin, which is indirectly inhibited by erythropoietic drive, in particular under pathological conditions characterized by expanded but ineffective erythropoiesis, such as β-thalassemia. 28629515 2017
CUI: C0005283
Disease: beta Thalassemia
beta Thalassemia
0.340 AlteredExpression disease BEFREE In comparison, individuals with beta-thalassemia syndromes had elevated GDF15 serum levels (mean 66,000 +/- 9,600 pg/ml; range 4,800-248,000 pg/ml; P < 0.05) that were positively correlated with the levels of soluble transferrin receptor, erythropoietin and ferritin. 17721544 2007
CUI: C0005283
Disease: beta Thalassemia
beta Thalassemia
0.340 AlteredExpression disease BEFREE However, rapid cellular apoptosis from alpha globin chain precipitation, and relatively low levels of endogenous erythropoietin (EPO) in some beta(+) thalassemia patients contribute to the anemia in beta thalassemia syndromes. 16304357 2005
CUI: C0005283
Disease: beta Thalassemia
beta Thalassemia
0.340 Therapeutic disease CTD_human Fetal haemoglobin augmentation in E/beta(0) thalassaemia: clinical and haematological outcome. 16225658 2005
CUI: C0005283
Disease: beta Thalassemia
beta Thalassemia
0.340 Biomarker disease BEFREE The ability of circulating progenitor cells to develop erythroid colonies was studied in vitro in the presence or absence of growth factors (5637-CM and erythropoietin) in 63 patients with sickle cell disease (SCD) (36 homozygotes for hemoglobin [Hb] S, 13 double heterozygotes for Hb S and beta thalassemia, and 14 SC patients) in Southeast Brazil. 10331510 1999