|
Stomach Carcinoma
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Stomach Carcinoma
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Stomach Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Clinicopathological significance of c-erbB-2 protein expression in human gastric carcinoma.
|
1348293 |
1992 |
|
Stomach Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Therapy of an animal model of human gastric cancer using a combination of anti-erbB-2 monoclonal antibodies.
|
1349849 |
1992 |
|
Stomach Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of the Her2/neu product p185 appears to be associated with intestinal-type gastric carcinoma and may help in identifying a subset of patients at increased risk for shorter survival.
|
1352299 |
1992 |
|
Stomach Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that erbB-2 protein expression is an important independent prognostic indicator in gastric cancer.
|
1670998 |
1991 |
|
Stomach Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this study, c-erbB-2 expression was investigated in 93 routinely processed cases of gastric carcinoma, using an immunohistochemical technique. c-erbB-2 membrane immunoreactivity was observed in 11% (10/93) of tumours, all of which were of the well differentiated intestinal type (p less than 0.01).
|
1676988 |
1991 |
|
Stomach Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
c-erbB-2 oncogene has been reported to be frequently amplified in differentiated, tubular type of gastric cancer.
|
2575609 |
1989 |
|
Stomach Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Both c-erbB-2 and the v-erbA homologue were expressed in all the stomach cancer cell lines tested.
|
3281095 |
1988 |
|
Stomach Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Occurrence of microsatellite instability in gastric carcinoma is associated with enhanced expression of erbB-2 oncoprotein.
|
7882346 |
1995 |
|
Stomach Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The role of EGF, the EGF receptor, and c-erbB-2 in human gastric cancer is reviewed on the basis of several reports, which have been mainly oriented toward their clinical significance.
|
7889468 |
1995 |
|
Stomach Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Amplification of the c-erbB-2 gene in gastric carcinoma: correlation with survival.
|
7901825 |
1993 |
|
Stomach Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
To investigate the correlation between the staining of c-erbB-2 protein and prognosis in gastric cancer, an additional 108 cases of papillary or well- to moderately differentiated tubular adenocarcinoma invasive as far as the muscularis propria were examined immunohistochemically for expression of c-erbB-2 protein.
|
7902202 |
1993 |
|
Stomach Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Paraffin-embedded specimens from 120 patients who underwent curative resection of gastric carcinoma were analyzed immunohistochemically for the expression of erbB-2.
|
7907434 |
1994 |
|
Stomach Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results indicate that fixation and paraffin wax embedding affect the results of immunohistochemical demonstration of c-erbB-2 in gastric cancer.
|
7907612 |
1994 |
|
Stomach Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tl investigate the possible role of c-erbB-2 oncogene in the oncogenesis of stomach cancer, we examined the genetic alterations of c-erbB-2 oncogene in 4 stomach cancer cell lines, SNU-1, SNU-5, SNU-16 and KATO III.
|
8104420 |
1993 |
|
Stomach Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Relationship of C-erbB-2 protein expression and gene amplification to invasion and metastasis in human gastric cancer.
|
8397058 |
1993 |
|
Stomach Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of c-erbB-2 occurred more commonly in intestinal GC and advanced GC of both types.
|
9136822 |
1997 |
|
Stomach Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
c-erbB2 and p53 expression are not associated with stage progression of gastric cancer in Britain or Japan.
|
9315057 |
1997 |
|
Stomach Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Amplification of c-erbB-2 in gastric cancer: detection in formalin-fixed, paraffin-embedded tissue by fluorescence in situ hybridization.
|
9520947 |
1998 |
|
Stomach Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Overexpression of the c-erbB-2 oncoprotein was more common in the intestinal type (15/32, 46.9%) and the advanced stage (19/45, 42.2%) than in the diffuse type (6/28, 21.4%) and the early stage (2/15, 13.3%) of GC (P<0.05).
|
9570245 |
1998 |
|
Stomach Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, our findings implicate HER2/neu-derived epitopes as potential candidates for novel immunotherapy and vaccine strategies against gastric cancer.
|
9754653 |
1998 |
|
Stomach Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of GAS and ERBB2 was observed by Western immunoblotting only in the gastric cancer cell line with gain at 17q12-q21.
|
9892105 |
1999 |
|
Stomach Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Therefore, the present study was conducted with the following three objectives: (1) to support the prognostic value of c-erbB-2 in gastric cancer in a large prospective series using a monoclonal antibody and a highly sensitive immunohistochemical method; (2) to determine the association of c-erbB-2 expression with the expression of invasion-related genes; and (3) to perform the first overall multivariate analysis including c-erbB-2 and the invasion-related tumor-associated protease systems.
|
10829039 |
2000 |
|
Stomach Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Amplifications of certain tyrosine kinases (c-met, k-sam and erbB2/neu) have been associated with human gastric cancer progression.
|
11114748 |
2000 |