ERBB3, erb-b2 receptor tyrosine kinase 3, 2065

N. diseases: 318; N. variants: 16
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 AlteredExpression disease BEFREE The expression of ErbB2 and ErbB3 receptors was unaltered in schizophrenia. 28646138 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE To our knowledge, this is the first association study between ERBB3 and schizophrenia in the Caucasian population. 19995212 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET To our knowledge, this is the first association study between ERBB3 and schizophrenia in the Caucasian population. 19995212 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 AlteredExpression disease BEFREE NRG1, ERBB3, and NGFR show expression changes during the years of greatest risk for the development of schizophrenia. 18470533 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 AlteredExpression disease BEFREE There is also growing evidence for abnormal expression of myelin-related genes in schizophrenia: Neuregulin (NRG1) is important for oligodendrocyte development and function, and altered expression of erbB3, one of the NRG1 receptors, has been shown in schizophrenia patients. 17485733 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 AlteredExpression disease BEFREE However, our failure to find genetic association suggests that the differential expression of ERBB3 in schizophrenia may be environmentally driven, or involve cis- or trans-acting genetic factors beyond the boundaries of the gene itself. 16958035 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET However, our failure to find genetic association suggests that the differential expression of ERBB3 in schizophrenia may be environmentally driven, or involve cis- or trans-acting genetic factors beyond the boundaries of the gene itself. 16958035 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE The present study shows that ERBB3 does not play a major role in conferring susceptibility to schizophrenia in the Japanese population. 17275115 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 AlteredExpression disease LHGDN However, our failure to find genetic association suggests that the differential expression of ERBB3 in schizophrenia may be environmentally driven, or involve cis- or trans-acting genetic factors beyond the boundaries of the gene itself. 16958035 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE RGS4 interacts with ErbB3 that acts as receptors for neuregulin 1 and these proteins may play a role in the pathogenesis of schizophrenia via glutamatergic dysfunction. 17092693 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET The present study shows that ERBB3 does not play a major role in conferring susceptibility to schizophrenia in the Japanese population. 17275115 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE Among the most consistent changes in genes with robust expression were significant decreases in the expression of myelination-related genes MAG, PLLP (TM4SF11), PLP1, ERBB3 in subjects with schizophrenia. 15334603 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 AlteredExpression disease BEFREE Recently, the gene that encodes neuregulin-1 (NRG1) has been identified as a potential susceptibility gene for schizophrenia, and defects in the expression of erbB3, one of the NRG1 receptors, have been shown to occur in the prefrontal cortex of schizophrenic patients, suggesting that NRG1-erbB signaling is involved in the pathogenesis of schizophrenia. 15162166 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 AlteredExpression disease LHGDN Recently, the gene that encodes neuregulin-1 (NRG1) has been identified as a potential susceptibility gene for schizophrenia, and defects in the expression of erbB3, one of the NRG1 receptors, have been shown to occur in the prefrontal cortex of schizophrenic patients, suggesting that NRG1-erbB signaling is involved in the pathogenesis of schizophrenia. 15162166 2004