|
Carcinoma of lung
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Carcinoma of lung
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Excision repair cross complementation group 1 polymorphisms and lung cancer risk: a meta-analysis.
|
21933627 |
2011 |
|
Carcinoma of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Excision repair cross-complementation group 1 (ERCC1) status and lung cancer outcomes: a meta-analysis of published studies and recommendations.
|
22022380 |
2011 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ERCC1-C118T was associated with lung cancer risk.
|
23727606 |
2013 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A Chinese case-control analysis comprising 370 cases and 388 controls was conducted to evaluate the effects of the high-risk diplotype predefined as PPP1R13L rs1970764(AA)-CD3EAP rs967591(GG)-ERCC1 rs11615(AA) among Caucasians and three SNPs alone or other haplotypes combined for lung cancer risk.
|
22335888 |
2012 |
|
Carcinoma of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
AC138128.1 an Intronic lncRNA originating from ERCC1 Implies a Potential Application in Lung Cancer Treatment.
|
31333777 |
2019 |
|
Carcinoma of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Collectively, these data suggest that there is a synergistic relationship between PARP inhibition and low ERCC1 expression in NSCLC that could be exploited for novel therapeutic approaches in lung cancer therapy based on tumor ERCC1 expression.
|
23275151 |
2013 |
|
Carcinoma of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer.
|
17314339 |
2007 |
|
Carcinoma of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Excision repair cross-complementary 1 (ERCC1) overexpression in lung cancer cells is strongly correlated with its resistance to platinum-based chemotherapy.
|
30668408 |
2019 |
|
Carcinoma of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Finally, expression of constitutive activate MKK6 or HA-p38 MAPK vectors in lung cancer cells was able to abrogate ERCC1 downregulation by metformin and paclitaxel as well as cell viability and DNA repair capacity.
|
23228696 |
2013 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Functional intronic ERCC1 polymorphism from regulomeDB can predict survival in lung cancer after surgery.
|
26056042 |
2015 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, a significant effect of SNPs in nucleotide excision repair pathway on lung cancer survival was observed among 185 stages III-IV patients treated with platinum-based chemotherapy without surgical operation: XPC rs2228000 (Ala499Val; P = 0.002) and ERCC1 rs11615 (Asn118Asn; P = 0.012).
|
21739480 |
2012 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study.
|
16690207 |
2007 |
|
Carcinoma of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hapmap-based evaluation of ERCC2, PPP1R13L, and ERCC1 and lung cancer risk in a Chinese population.
|
22351191 |
2012 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study indicated no association between mRNA expression of the DNA-repair genes ERCC1 and XPD and risk of subsequent development of lung cancer.
|
16054657 |
2006 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In order to comprehensively capture common genetic variation in the ERCC1 gene, Caucasian data from the International HapMap project was used to assess linkage disequilibrium and choose four tagSNPs (rs1319052, rs3212955, rs3212948, and rs735482) in the ERCC1 gene to genotype 452 lung cancer cases, 175 H&N cancer cases, and 790 healthy controls.
|
20863778 |
2011 |
|
Carcinoma of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the expression of excision repair cross-complementation group 1 (ERCC1) protein in 90 completely resected lung cancer samples from patients who received adjuvant or neo-adjuvant platinum-based chemotherapy.
|
18395930 |
2008 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
MDR (multifactor dimensionality reduction) analysis demonstrated the best significant model of two-attributes containing smoking duration and rs2298881 in ERCC1 (P=0.004-0.005) and suggested that the effects of high-order interactions among smoking duration and ERCC2, PPP1R13, ERCC1 htSNPs could modulate lung cancer risk.
|
24140460 |
2013 |
|
Carcinoma of lung
|
0.600 |
Biomarker
|
disease |
RGD |
Molecular analysis of DNA repair gene methylation and protein expression during chemical-induced rat lung carcinogenesis.
|
21530494 |
2011 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No significant associations with lung cancer susceptibility were observed for global or individual haplotypes defined by five htSNPs of ERCC1.
|
21601580 |
2011 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that rs3212986 polymorphism in 3'UTR of ERCC1 overlapped with CD3EAP may affect the repair of the damage induced by BPDE mainly via regulating ERCC1 expression and become a potential biomarker to predict smoking-related lung cancer.
|
30453383 |
2018 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that polymorphism Asn118Asn in ERCC1, A67T in iASPP and Asn148Glu in APE1 may associated with early onset of lung cancer as well as some specific subtype of lung cancer.
|
20354815 |
2011 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Pooled ORs from 11 eligible studies (8,215 cases vs. 11,402 controls) suggested a significant association of ERCC1 rs11615 with increased risk for lung cancer (homozygous: CC versus TT, OR = 1.24, 95% CI: 1.04-1.48, P = 0.02).
|
24841208 |
2014 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ERCC1 rs321986 GT and TT genotypes (at radon concentrations >200 Bq/m<sup>3</sup>) were more significantly associated with higher lung cancer risk (OR = 2.40, 95% CI = 1.29-4.45; OR = 4.45, 95% CI = 1.26-15.7, respectively).
|
31446980 |
2019 |