|
CEREBROOCULOFACIOSKELETAL SYNDROME 4
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia.
|
23623389 |
2013 |
|
CEREBROOCULOFACIOSKELETAL SYNDROME 4
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia.
|
23623389 |
2013 |
|
CEREBROOCULOFACIOSKELETAL SYNDROME 4
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia.
|
23623389 |
2013 |
|
CEREBROOCULOFACIOSKELETAL SYNDROME 4
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure.
|
17273966 |
2007 |
|
CEREBROOCULOFACIOSKELETAL SYNDROME 4
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure.
|
17273966 |
2007 |
|
CEREBROOCULOFACIOSKELETAL SYNDROME 4
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure.
|
17273966 |
2007 |
|
CEREBROOCULOFACIOSKELETAL SYNDROME 4
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
CEREBROOCULOFACIOSKELETAL SYNDROME 4
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ERCC1 rs321986 GT and TT genotypes (at radon concentrations >200 Bq/m<sup>3</sup>) were more significantly associated with higher lung cancer risk (OR = 2.40, 95% CI = 1.29-4.45; OR = 4.45, 95% CI = 1.26-15.7, respectively).
|
31446980 |
2019 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
AC138128.1 an Intronic lncRNA originating from ERCC1 Implies a Potential Application in Lung Cancer Treatment.
|
31333777 |
2019 |
|
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results show that the ZNF326 transcription factor is highly expressed in lung cancer and promotes the proliferation of NSCLC cells by regulating the expression of ERCC1.
|
30401956 |
2019 |
|
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Excision repair cross-complementary 1 (ERCC1) overexpression in lung cancer cells is strongly correlated with its resistance to platinum-based chemotherapy.
|
30668408 |
2019 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
We utilized the CRISPR-Cas9 system to create a panel of ERCC1Δ lung cancer cell lines which we characterized.
|
30538112 |
2019 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ERCC1 rs321986 GT and TT genotypes (at radon concentrations >200 Bq/m<sup>3</sup>) were more significantly associated with higher lung cancer risk (OR = 2.40, 95% CI = 1.29-4.45; OR = 4.45, 95% CI = 1.26-15.7, respectively).
|
31446980 |
2019 |
|
Carcinoma of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
We utilized the CRISPR-Cas9 system to create a panel of ERCC1Δ lung cancer cell lines which we characterized.
|
30538112 |
2019 |
|
Carcinoma of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Excision repair cross-complementary 1 (ERCC1) overexpression in lung cancer cells is strongly correlated with its resistance to platinum-based chemotherapy.
|
30668408 |
2019 |
|
Carcinoma of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results show that the ZNF326 transcription factor is highly expressed in lung cancer and promotes the proliferation of NSCLC cells by regulating the expression of ERCC1.
|
30401956 |
2019 |
|
Carcinoma of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
AC138128.1 an Intronic lncRNA originating from ERCC1 Implies a Potential Application in Lung Cancer Treatment.
|
31333777 |
2019 |
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that rs3212986 polymorphism in 3'UTR of ERCC1 overlapped with CD3EAP may affect the repair of the damage induced by BPDE mainly via regulating ERCC1 expression and become a potential biomarker to predict smoking-related lung cancer.
|
30453383 |
2018 |
|
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
CTD_human |
Our findings suggest that rs3212986 polymorphism in 3'UTR of ERCC1 overlapped with CD3EAP may affect the repair of the damage induced by BPDE mainly via regulating ERCC1 expression and become a potential biomarker to predict smoking-related lung cancer.
|
30453383 |
2018 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that rs3212986 polymorphism in 3'UTR of ERCC1 overlapped with CD3EAP may affect the repair of the damage induced by BPDE mainly via regulating ERCC1 expression and become a potential biomarker to predict smoking-related lung cancer.
|
30453383 |
2018 |
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Functional intronic ERCC1 polymorphism from regulomeDB can predict survival in lung cancer after surgery.
|
26056042 |
2015 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Functional intronic ERCC1 polymorphism from regulomeDB can predict survival in lung cancer after surgery.
|
26056042 |
2015 |
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Pooled ORs from 11 eligible studies (8,215 cases vs. 11,402 controls) suggested a significant association of ERCC1 rs11615 with increased risk for lung cancer (homozygous: CC versus TT, OR = 1.24, 95% CI: 1.04-1.48, P = 0.02).
|
24841208 |
2014 |
|
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that the ERCC1 19007T>C polymorphism may be associated with lung cancer risk in Asians, while larger scale association studies are necessary to further validate the association of 19007T>C polymorphism with lung cancer risk.
|
25051148 |
2014 |