|
Adenocarcinoma Of Esophagus
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Variant alleles in NER SNPs XPD Lys751Gln (AOR = 1.50, 95% CI 1.1-2.0), ERCC1 8092 C/A (AOR = 1.44, 95% CI 1.1-1.9), and ERCC1 118C/T (AOR = 1.42, 95% CI 1.0-1.9) were individually associated with esophageal adenocarcinoma risk.
|
18478337 |
2008 |
|
Adenocarcinoma Of Esophagus
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
XPD codon 751 Lys/Gln and Gln/Gln genotypes, compared with Lys/Lys genotype, were both associated with a more than doubled risk for esophageal adenocarcinoma (OR=2.4; 95% CI=1.4-4.4; OR=2.7, 95% CI=1.3-5.9).
|
16571649 |
2006 |
|
Adenocarcinoma Of Esophagus
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis suggested that the ERCC2 Asp312Asn polymorphism might be associated with increased risk of esophageal adenocarcinoma and a protective factor for esophageal squamous cell carcinoma.
|
24234258 |
2014 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In stratified analyses, the variant A-allele of XPD Arg156Arg was associated with increased risk of adenocarcinoma of lung (AA/AC versus CC; adjusted OR=1.65; 95% CI=1.09-2.50) (P=0.02).
|
15896456 |
2005 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
ERCC2 rs50871 and ATM rs611646 showed significant association with EGFR wild-type lung adenocarcinoma in the discovery stage.
|
29173771 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
This study showed that the individuals with the combined ERCC2 751AC/CC genotypes were at an increased risk for lung adenocarcinoma compared with those carrying the AA genotype [adjusted odds ratios (OR) 1.64, 95% confidence interval (CI) 1.06-2.52].
|
20003391 |
2009 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
Biomarker
|
disease |
BEFREE |
However, multifactor dimensionality reduction analysis showed that the genetic polymorphisms of the three-loci models of DNA repair genes (XPD-751/XRCC1-399/OGG1-326) are associated with lung ADC.
|
23700156 |
2013 |
|
Adenoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Carriers of the variant XPD 751Gln allele had an increased risk of low-risk adenomas (OR 1.40, 95% CI 1.03-1.89), while no association was found with risk of carcinomas.
|
16542436 |
2006 |
|
Adenoma
|
0.020 |
Biomarker
|
group |
BEFREE |
Analyses ignoring XPD showed no association between alcohol intake and adenoma prevalence; however, among carriers of the codon 751 Gln/Gln genotype, we found a significant positive association (OR, 2.5; 95% CI, 1.2-5.2 for ever drinkers; test of interaction P = 0.04).
|
17164360 |
2006 |
|
Adenoma of large intestine
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Overall, no relevant common findings emerge among the studies, except for some statistically significant associations between polymorphisms in the XRCC1 and XPD genes, mainly for colorectal adenoma risk.
|
17419091 |
2007 |
|
Adenoma of large intestine
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We used a case-control study design (157 carcinomas, 983 adenomas and 399 controls) to test the association between five polymorphisms in these DNA repair genes (XRCC1 Arg194Trp, Arg280His, Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln), and risk of colorectal adenomas and carcinomas in a Norwegian cohort.
|
16542436 |
2006 |
|
Adenoma of large intestine
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk.
|
17164360 |
2006 |
|
Adenomatous Polyps
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Overall, a homozygous variant XPD-combined genotype was associated with an increased risk of adenomatous polyps [odds ratio (OR), 1.57; 95% confidence interval (95% CI), 1.04-2.38] and an XPGHH1104 genotype with a decreased risk of hyperplastic polyps (OR, 0.36; 95% CI, 0.13-0.98).
|
16284370 |
2005 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma.
|
23619945 |
2013 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma.
|
30279407 |
2018 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Excision repair cross-complementing group 2/Xeroderma pigmentousm complementation group D (ERCC2/XPD) genetic variations and susceptibility to diffuse large B cell lymphoma in Egypt.
|
24258710 |
2013 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
However, the XPD 751 Gln allele was associated with a two-fold decreased risk of diffuse large B-cell lymphoma (OR 0.56, 95% CI 0.34-0.92, p=0.02), the major subtype of NHL.
|
19736055 |
2009 |
|
Adult Glioblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results pointed out that MLH1 rs1800734 and ERCC2 rs13181 polymorphisms might constitute glioblastoma susceptibility factors, and also suggested that the chromosomal region 19q could be important in glioblastoma pathogenesis.
|
24325908 |
2014 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We aimed to establish whether XRCC1, XRCC3, and XPD are associated with liver cancer in Pakistan and to examine the interaction of hepatitis B virus (HBV) or hepatitis C virus (HCV) with repaired genes in the occurrence of liver cancer.
|
23044807 |
2013 |
|
Adult Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma.
|
22047709 |
2012 |
|
Adult Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To investigate the relationship between DNA repair and NHL we analysed polymorphisms in XPD (R156R, D312N, K751Q) using DNA collected in a UK population-based case-control study of lymphoma.
|
19736055 |
2009 |
|
Adult Meningioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that Ki-ras and ERCC2 SNPs are possible markers for meningioma formation, whereas cyclin D1 and p16 SNPs may be markers of genes that have an inverse effect on the risk to develop meningioma in irradiated and nonirradiated populations.
|
15824172 |
2005 |
|
Adult Myelodysplastic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome.
|
26482462 |
2016 |
|
Adult Non-Hodgkin Lymphoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Comprehensive assessment of associations between ERCC2 Lys751Gln/Asp312Asn polymorphisms and risk of non- Hodgkin lymphoma.
|
25422223 |
2014 |
|
Adult Non-Hodgkin Lymphoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the nucleotide excision repair gene ERCC2/XPD and risk of non-Hodgkin lymphoma.
|
19736055 |
2009 |