|
Osteosarcoma
|
0.400 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Osteosarcoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8.
|
16142341 |
2005 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, we detected a time-dependent decrease in VEGF expression and considerably reduced phosphoinositide 3-kinase (PI3K) and protein kinase B (AKT) activation in osteosarcoma cells treated by Eag1 shRNA.
|
23202914 |
2012 |
|
Osteosarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, after stratified analysis, the genotype AA of AKT rs6973569 carried a higher risk of osteosarcoma metastasis (OR:2.94, 95%CL:1.00-8.59); the difference of rs7646409 genotype distributions between the case and control groups was statistically significant (P = 0.032).
|
24175786 |
2013 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, Western blot showed that metformin activated AMPKα at Tyr172, followed by a downregulated phosphorylation of mammalian target of rapamycin (mTOR)/S6 and feedback activation of p-AKT Ser(473) in both OS MG63 cells and CSCs.
|
26164004 |
2015 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gelsolin promotes cell growth and invasion through the upregulation of p-AKT and p-P38 pathway in osteosarcoma.
|
26662962 |
2016 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, our findings identify phospho-AKT in the primary tumor and miR-200c later during tumor progression as prognostic molecules and potential therapeutic targets to prevent progression and metastasis of pediatric osteosarcomas.
|
27155790 |
2016 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We also found that the activations of phosphoinositide 3-kinase (PI3K) and protein kinase B (AKT) were considerably reduced after osteosarcoma cells were treated with Lv-shVEGF.
|
27352347 |
2015 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, miR-92a that exerts an oncogenic role by targeting PTEN/AKT pathway in OS potentially acts as a biomarker and drug-target.
|
28260104 |
2017 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, we demonstrate that RhoA acts as the downstream of PI3K/Akt signaling (specific PI3Kα, Akt1 and Akt2 isoforms) and mediated Wnt5a-induced the migration of osteosarcoma cells.
|
28289332 |
2017 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, we further found that those effects on osteosarcoma by NRSN2 are associated with the dysregulated PI3K/AKT/mTOR signaling and Wnt/β-catenin signaling.
|
28401012 |
2017 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
As the anti-miR-19a inhibited the phosphatidylinositol 3-kinase/AKT pathway and induced apoptosis of human osteosarcoma-cancer stem cells, the phosphatase and tensin homolog deleted on chromosome 10 small interfering RNA inhibited the effect of it.
|
28475001 |
2017 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In total, 60 osteosarcomas (76.9%) expressed RANK and 58 cases (74.4%) showed expression of Akt1.
|
28587351 |
2017 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Deoxypodophyllotoxin induces cytoprotective autophagy against apoptosis via inhibition of PI3K/AKT/mTOR pathway in osteosarcoma U2OS cells.
|
28623712 |
2017 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A correlation analysis between tumor imaging changes and p-AKT and HSP70 expression in tumor cells after osteosarcoma chemotherapy.
|
29151914 |
2017 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PP2A was a direct target of miR-21, which participated in the effects of ASBEL and miR-21 on the activation of phosphatidylinositol 3-kinase/protein kinase 3/glycogen synthase kinase-3β (PI3K/AKT/GSK3β) and mitogen-activated protein kinase/extracellular regulated protein kinase (MEK/ERK) signaling pathways as well as the enhancement of osteosarcoma cell proliferation, migration, and invasion.
|
29323740 |
2018 |
|
Osteosarcoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
We also showed that GCB reduces the phosphorylation of AKT, mTOR and p70S6K and that GCB-induced autophagy in OS can lead to either cell survival or cell death.
|
29416717 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, the results of the present study indicate that the expression of miRNA-21, PI3K and AKT is increased in the osteosarcoma cell line MG-63, which results in reduced expression of PTEN and increased expression of proteins in the PI3K/AKT signaling pathway, and thus increases the aggressiveness of osteosarcoma cells.
|
29434694 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MicroRNA-124 suppresses growth and aggressiveness of osteosarcoma and inhibits TGF-β-mediated AKT/GSK-3β/SNAIL-1 signaling.
|
29488603 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fibroblast activation protein in osteosarcoma cells promotes angiogenesis via AKT and ERK signaling pathways.
|
29552230 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Western blot analysis was performed to detect the expression levels of phosphatidylinositol 3‑kinase (PI3K), phospho (p)‑PI3K, RAC‑alpha serine/threonine‑protein kinase (AKT), p‑AKT and NF‑κB inhibitor α (IκBα) in osteosarcoma cells transfected with H19 siRNA.
|
29568924 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Global gene expression profiling of CEP55-silenced MNNG/HOS cells showed that the AKT pathway might be involved in the regulation of OS cell activity.
|
29579156 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results indicate that miR-19a-mediated RhoB is a critical regulator for the dephosphorylation of AKT1 in osteosarcoma cells.
|
29702193 |
2018 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lowly expressed microRNA-520d-3p was observed in osteosarcoma; overexpression of microRNA-520d-3p can target Akt1 thus inhibiting proliferation of osteosarcoma cells.
|
29762834 |
2018 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
<i>In vivo</i> assays revealed that lnPTENP1 transfection significantly inhibited osteosarcoma tumor growth and significantly increased the protein expression and phosphorylation levels of PI3K and AKT.
|
29805503 |
2018 |