|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation.
|
25761777 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, the association between therapeutic efficacy and putative proapoptotic activity of low-dose BVZ either alone or in combination with a specific inhibitor of AKT called perifosine (PRF), in a glioma model was investigated.
|
28616662 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PI3K-AKT-mTOR signaling is a valuable treatment target for human glioma.
|
29228741 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data firstly demonstrated that CREB1-induced FOXD2-AS1 contributed to glioma progression by upregulating AKT1 via competitively binding to miR-185, providing a novel strategy for targeting FOXD2-AS1 as a potential biomarker and a therapeutic target in glioma patients.
|
30553445 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
LHGDN |
The initial characterization of SH-6 included treatment of glioma cells with increasing doses of SH-6 (0.30-30 microM) and examining the effects on AKT signaling proteins by Western blot analyses and in kinase assays with immunoprecipitated AKT1.
|
17041888 |
2006 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma.
|
29535541 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Western blot of p21, p27 and AKT indicated the possible role of TRIM44 in regulation AKT pathway in glioma.
|
31605296 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The RAS/RAF mitogen-activated protein kinase pathway (MAPK) is highly active in many tumor types including the majority of high-grade gliomas and expression of activated RAS or RAF in neural progenitor cells combined with either AKT activation or Ink4a/Arf loss leads to the development of high-grade gliomas in vivo.
|
21057530 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-1231 exerts a tumor suppressor role through regulating the EGFR/PI3K/AKT axis in glioma.
|
29774498 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that Liq treatment enhances glioma cell susceptibility to TMZ by inhibiting the PI3K/AKT/mTOR pathway.
|
25351348 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
While cross talk between the Wnt/β-catenin and PI3K/AKT signaling pathways has been proposed, the impact of PI3K/AKT inhibition on β-catenin signaling in glioma remains unknown.
|
20888802 |
2010 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our research indicated a MEG3-miR-93-PI3K-AKT pathway in regulating the growth of glioma, providing a promising therapy for glioma.
|
28791407 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we confirmed that lncRNA SNHG16 was highly expressed in glioma and may exert oncogenic function as a competing endogenous RNA (ceRNA) to regulate EGFR by sponging of miR-373-3p through activating PI3K/AKT pathway, which providing a new insight of the regulatory network of lncRNA SNHG16 in the development of glioma.
|
31226483 |
2020 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Preclinical data in a pediatric glioma model demonstrated that the combination of perifosine (AKT inhibitor) and temsirolimus (mTOR inhibitor) is more potent at inhibiting the axis than either agent alone.
|
28035748 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study suggests that SPOCK1 promotes proliferation, migration and invasion in glioma cells by activating PI3K/AKT and Wnt/β-catenin pathways, which provides a potential theoretical basis for clinical treatment of glioma.
|
27108836 |
2016 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MiR-199a-3p in glioma cell lines has effects similar to the tumor suppressor gene on cellular proliferation via the AKT/mTOR signaling pathway.
|
25854175 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results support the concept that β-catenin/Tcf-4 directly regulates AKT1 in glioma, and these two proteins may cooperate with each other in exerting their oncogenic effects in glioma.
|
21720709 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therapy based on AKT inhibition may complement currently available treatment to control glioma cell invasion.
|
15557754 |
2005 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The circ-CFH/miR-149/AKT1 regulation axis may be a potential target for glioma therapy.
|
30111766 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The initial characterization of SH-6 included treatment of glioma cells with increasing doses of SH-6 (0.30-30 microM) and examining the effects on AKT signaling proteins by Western blot analyses and in kinase assays with immunoprecipitated AKT1.
|
17041888 |
2006 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRCA1-associated protein inhibits glioma cell proliferation and migration and glioma stem cell self-renewal via the TGF-β/PI3K/AKT/mTOR signalling pathway.
|
31776938 |
2020 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Its efficacy as a single agent or in combination with TMZ was assessed <i>in vitro</i> and <i>in vivo</i> using zebrafish and patient-derived GSC xenograft mouse glioma models.<b>Results:</b> Onalespib-mediated HSP90 inhibition depleted several survival-promoting client proteins such as EGFR, EGFRvIII, and AKT, disrupted their downstream signaling, and decreased the proliferation, migration, angiogenesis, and survival of glioma cell lines and GSCs.
|
28679777 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these data indicate that IL-17 can promote the proliferation and migration of glioma cells via PI3K/Akt1/NF-κB-p65 activation, and these findings might provide a new insight into glioma pathogenesis.
|
30660646 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The newly identified miR-92a/KLF4/AKT/mTOR axis provides novel insight into the pathogenesis of glioma.
|
31378903 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Restoration of LASP1 expression in miR-377-3p-overexpressing cells attenuated the inhibition of glioma cell malignancy and reversed the dephosphorylation of AKT.
|
30372896 |
2018 |