AKT1, AKT serine/threonine kinase 1, 207

N. diseases: 1250; N. variants: 33
Disease: Lung Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker group BEFREE Moreover, knockdown of AKT1 obviously impaired MAT1-mediated promotions in cell migration and invasion in vitro, as well as repressed tumor growth and reduced the number of metastatic lung tumors in xenografted nude mice. 31421084 2019
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker group BEFREE Thus far, the AKT inhibitors being evaluated broadly target all three (1-3) AKT isoforms but recent evidence suggests opposing roles in lung tumorigenesis where loss of Akt1 inhibits while the loss of Akt2 enhances lung tumor development. 29470540 2018
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker group BEFREE Using a transgenic mouse model where IGF-IR overexpression drives lung tumorigenesis, we found that loss of Akt1 inhibited while loss of Akt2 enhanced lung tumor development. 26654940 2016
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker group BEFREE Combinatorial use of the mTOR inhibitor and AKT inhibitor MK2206 robustly inhibited the growth and viability of squamous lung tumors, thus providing an effective strategy to overcome resistance. 26574479 2015
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 AlteredExpression group BEFREE Typical HER2 downstream signaling mediators, including PLCγ1, STAT5 and AKT, were hyperactivated in HER2H878Y driven lung tumors. 26375550 2015
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 AlteredExpression group BEFREE We analyzed the activation of the phosphatidyl inositol-3-kinase (PI3K)/AKT pathway and the mitogen-activated protein kinase/extracellular-signal regulated kinase (MAPK/ERK) pathway in lung tumors. 24374738 2014
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker group CTD_human Suppression of lung cancer progression by biocompatible glycerol triacrylate-spermine-mediated delivery of shAkt1. 22619562 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Therapeutic group CTD_human Suppression of lung cancer progression by biocompatible glycerol triacrylate-spermine-mediated delivery of shAkt1. 22619562 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker group CTD_human Aerosol delivery of spermine-based poly(amino ester)/Akt1 shRNA complexes for lung cancer gene therapy. 21911043 2011
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Therapeutic group CTD_human Aerosol delivery of spermine-based poly(amino ester)/Akt1 shRNA complexes for lung cancer gene therapy. 21911043 2011
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 AlteredExpression group LHGDN CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways. 19073147 2009
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker group BEFREE These experiments provide the first evidence that inhibition of p-AKT and induction of p-ERK1/2 are crucial events in the induction of TIMP-3-mediated endothelial apoptosis in MMP-2 inhibited lung tumors. 18559520 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 PosttranslationalModification group LHGDN The potential role of Akt phosphorylation in human cancers. 18409144 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 AlteredExpression group LHGDN Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair. 18644989 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 GeneticVariation group LHGDN Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. 18256540 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker group LHGDN AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. 17616691 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker group LHGDN Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways. 16820947 2006
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 AlteredExpression group LHGDN Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. 15802268 2005
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Therapeutic group CTD_human Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. 12511591 2003
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker group CTD_human Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. 12511591 2003
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker group HPO