AKT1, AKT serine/threonine kinase 1, 207

N. diseases: 1250; N. variants: 33
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE While the loss of endothelial FTO did not influence the development of obesity and dyslipidemia, it protected mice from high fat diet (HFD)- induced glucose intolerance and insulin resistance by increasing AKT phosphorylation in endothelial cells and skeletal muscle. 31801409 2020
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE PI3K/AKT pathway damaged in various tissues of the body leads to obesity and type 2 diabetes as the result of insulin resistance, and in turn, insulin resistance exacerbates the PI3K/AKT pathway, forming a vicious circle. 30263000 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.400 PosttranslationalModification disease BEFREE Chronic intracellular Ca<sup>2+</sup> overload in hepatocytes during obesity and hyperlipidemia attenuates the phosphorylation of protein kinase B (Akt) and its key downstream signaling molecules by inhibiting membrane localization of pleckstrin homology (PH) domains. 29078297 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE Baicalin against obesity and insulin resistance through activation of AKT/AS160/GLUT4 pathway. 28359800 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE Consistently, ablation of Akt1 mitigated the obesity and BAT dysfunction induced by DJ-1 transgene. 28224045 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE Genetic variations in the PI3K/AKT/mTOR signaling pathway may be associated with an increasing risk of obesity and diabetes. 28477532 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE VMH-specific inhibition of TBK-1 in mice with diet-induced obesity impaired glucose metabolism and AKT activation. 28550108 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE Hypersecretion of IGF1 causes increased expression of lipogenic genes via activating the protein kinase B (PKB; also known as Akt)-mammalian target of rapamycin (mTOR) pathway in adipose tissues, which contributes to the development of obesity, diabetes, and hepatic steatosis as the KI mice age. 27307439 2016
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE Our obese mouse models demonstrated activation of the AKT/mTOR pathway in obesity-accelerated mammary tumor growth (3.7- to 7.0-fold; P < .001; n = 6-7 mice per group). 24957076 2014
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease CTD_human Obese mouse ovaries had decreased Irs1, Foxo3a, Cyp2e1, MiR-103, and MiR-21 but increased Kitlg, Akt1, and miR-184 levels relative to lean littermates. 23954404 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE Phospho-AKT/total AKT ratio and pathways associated with antiapoptosis, inflammation, insulin resistance, and obesity were also significantly reduced in NCKD relative to MCD tumors. 19470786 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE Adult heterozygous Pps mutant mice show increased insulin sensitivity and reduced diet-induced obesity with increased Akt/protein kinase B (PKB) phosphorylation in skeletal muscle but not in adipose tissue. 18573875 2008