AKT1, AKT serine/threonine kinase 1, 207

N. diseases: 1250; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE We propose that through convergence on AKT/mTOR signaling, these genes are critical factors directing both placentation and neurodevelopment, influencing risk for SCZ through dysregulation of placental function, metabolism and early brain development. 31522868 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE This association is likely to reflect modulation of dopamine signaling by Akt1 kinase since striatal dopamine hyperstimulation is associated with psychosis and schizophrenia. 28416594 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE With this premise, this study examined in HeLa and other cell lines the effects of different APDs on the activation of ERK1/2 (Extracellular signal-regulated kinases) and AKT (Protein Kinase B) kinases, which may be affected in schizophrenia and bipolar disorder. 28283227 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation disease BEFREE The intronic single-nucleotide polymorphism rs707284 in ERBB4 links to PI3K-AKT suppression in SZ. 28384043 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia. 28467426 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE These results implicate dopaminergic dysregulation as a mechanism underlying the increased rate of schizophrenia seen in DISC1 variant carriers, and provide insights into how DISC1, and potentially DISC1-interacting proteins such as AKT and GSK-3, could be used as novel therapeutic targets for schizophrenia. 28140405 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 AlteredExpression disease BEFREE Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia. 27484635 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation disease BEFREE The current study examined the interactive effects of TCF4 and AKT1 variants with gender, family history of psychiatric disorders and ethnicity on the AAO of schizophrenia. 27305091 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE Many susceptible genes have been identified in schizophrenia such as catechol-O-methyltransferase (COMT) and serine/threonine kinase (AKT1). 25801838 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation disease BEFREE This analysis identified 624 genes with altered expression (208 up-regulated, 416 down-regulated) prior to antipsychotic treatment (p < 0.05) including schizophrenia-associated genes AKT1, DISC1 and DGCR6. 23442539 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease GENOMICS_ENGLAND Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes. 23246288 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation disease BEFREE Our results suggest that a genetic variant of AKT1 might be associated with attentional deficits and brain morphological vulnerability in patients with schizophrenia. 22150081 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation disease BEFREE No association between AKT1 gene variants and schizophrenia: a Malaysian case-control study and meta-analysis. 23747160 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE Taken together, these results implicate the Akt1 isoform in regulating hippocampal neuroplasticity and cognition and in contributing to the etiology of schizophrenia. 21049487 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation disease BEFREE In this study, our aim was to determine whether AKT1 gene variants are associated with particular phenotypes for schizophrenia (SCZ) and bipolar disorder (BPD). 22277669 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation disease BEFREE In the context of anti-psychotic drugs, the DRD2 and AKT1 polymorphisms altered dose-response effects of anti-psychotic drugs on cognition in schizophrenia (n = 111). 22525159 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE Patients with schizophrenia displayed decreased AKT but normal ERK ratio compared with controls. 22209534 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE Genetic linkage and association studies have identified Akt-1 as a candidate susceptibility gene related for schizophrenia. 22771711 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE Our findings suggest that AKT1 affects risk for schizophrenia and accompanying cognitive deficits, at least in part through specific genetic interactions related to brain neuroplasticity and development, and that these AKT1 effects may be pharmacologically modulated in patients. 21788944 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 AlteredExpression disease BEFREE The purpose of this review is to detail how putative schizophrenia risk genes (DISC-1, neuregulin/ErbB4, dysbindin, Akt1, BDNF, and the NMDA receptor) are involved in regulating neuroplasticity and how alterations in their expression may contribute to the disconnectivity observed in schizophrenia. 20951727 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE We measured AKT1 and GSK-3β proteins and phosphorylation in human peripheral blood mononuclear cells, functional MRI cingulate response during attentional control, behavioral accuracy during sustained attention, and response to 8 wk of treatment with olanzapine in a total of 190 healthy subjects and 66 patients with schizophrenia. 21187413 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease CTD_human We measured AKT1 and GSK-3β proteins and phosphorylation in human peripheral blood mononuclear cells, functional MRI cingulate response during attentional control, behavioral accuracy during sustained attention, and response to 8 wk of treatment with olanzapine in a total of 190 healthy subjects and 66 patients with schizophrenia. 21187413 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE Several publications support the implication of AKT1 in disorders of the dopaminergic system including bipolar disease and schizophrenia. 21741444 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE Taken together, our results do not support the hypothesis that AKT1 is a susceptibility gene for schizophrenia. 19931325 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker disease BEFREE In conclusion, our findings, by showing the involvement of the AKT1 gene in both schizophrenia and bipolar disorder, support the role of AKT1 in the genetics of both disorders and add support to the view that there is some genetic overlap between them. 20214684 2010