|
Squamous cell carcinoma of tongue
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We have demonstrated that the overexpression of TFIIH correlates positively with node metastasis, while XPF correlates negatively with node metastasis; therefore, the expression of XPF and TFIIH had a potential value for predicting the progression of OTSCC patients.
|
31828418 |
2020 |
|
Developmental Disabilities
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Remarkably, these early transcriptional events are affected by TFIIE and TFIIH mutations associated with the developmental disorder, trichothiodystrophy.
|
31064989 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-192-5p partially reversed GC cisplatin resistance by targeting ERCC3 and ERCC4, which participate in the NER pathway, suggesting that miR-192-5p may be a potential biomarker and therapeutic target for GC cisplatin resistance.
|
30854110 |
2019 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-192-5p partially reversed GC cisplatin resistance by targeting ERCC3 and ERCC4, which participate in the NER pathway, suggesting that miR-192-5p may be a potential biomarker and therapeutic target for GC cisplatin resistance.
|
30854110 |
2019 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Drug-induced, proteasome-dependent XPB degradation may be a useful therapeutic approach in cardiovascular diseases driven by inflammation.
|
29036418 |
2018 |
|
Hypertensive disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Importantly, SPL treatment decreased whole lung XPB protein levels in a monocrotaline rat model of pulmonary hypertension and reduced inflammatory markers in an observational cohort of PAH patients.
|
29036418 |
2018 |
|
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altogether, we show that NER impacts alkylating agents sensitivity in myeloma cells and identify ERCC3 as a potential therapeutic target in MM.
|
28588253 |
2018 |
|
Idiopathic pulmonary arterial hypertension
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Importantly, SPL treatment decreased whole lung XPB protein levels in a monocrotaline rat model of pulmonary hypertension and reduced inflammatory markers in an observational cohort of PAH patients.
|
29036418 |
2018 |
|
Nasal Polyps
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, when we stratified ERCC2, ERCC3 and XRCC1 polymorphism genotypes by the median and 75th percentiles of blood-Cd levels, we found also significant interactions between ERCC2 (Lys751Gln) and ERCC3 (7122 A>G) genotypes polymorphism and this metal in association with NP disease.
|
27838878 |
2017 |
|
UV-Sensitive Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, our results also found ERCC2(XPD), ERCC3(XPB) or ERCC5(XPG) mutations in two cases of UV-sensitive syndrome and in two cases with mixed XP/CS phenotypes.
|
27004399 |
2016 |
|
Xeroderma pigmentosum, group G
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that the XPG-TFIIH complex is involved in transcription elongation and that defects in this association may partly account for Cockayne syndrome in XP-G/CS patients.
|
26149386 |
2015 |
|
Rift Valley Fever
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.
|
24403578 |
2014 |
|
Sleep Apnea, Central
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of CSA reduces pre-rRNA synthesis by RNA polymerase I. CSA associates with RNA polymerase I and the active fraction of the rDNA and stimulates re-initiation of rDNA transcription by recruiting the Cockayne syndrome proteins TFIIH and CSB.
|
24781187 |
2014 |
|
Cockayne Syndrome, Type I
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of CSA reduces pre-rRNA synthesis by RNA polymerase I. CSA associates with RNA polymerase I and the active fraction of the rDNA and stimulates re-initiation of rDNA transcription by recruiting the Cockayne syndrome proteins TFIIH and CSB.
|
24781187 |
2014 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
FUSE-binding protein-interacting repressor (FIR), a splicing variant of PUF60 lacking exon5, is a c-Myc transcriptional target that suppresses the DNA helicase p89 (ERCC3) and is alternatively spliced in colorectal cancer lacking the transcriptional repression domain within exon 2 (FIRΔexon2).
|
23594796 |
2013 |
|
Leukopenia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
These associations remained the same when ERCC3 promoter methylation and WBCs were dichotomized according to the 90th percentile (≥6%) of methylation levels in controls and a leucopenia cutoff (<4 × 10(9) /L), respectively.
|
23797950 |
2013 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
RECQL1 DNA repair helicase: a potential therapeutic target and a proliferative marker against ovarian cancer.
|
23951333 |
2013 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
FUSE-binding protein-interacting repressor (FIR), a splicing variant of PUF60 lacking exon5, is a c-Myc transcriptional target that suppresses the DNA helicase p89 (ERCC3) and is alternatively spliced in colorectal cancer lacking the transcriptional repression domain within exon 2 (FIRΔexon2).
|
23594796 |
2013 |
|
Premature aging syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
XPB and XPD genetic defects can also cause premature aging with profound neurological defects without increased cancers: Cockayne syndrome (CS) and trichothiodystrophy (TTD).
|
21571596 |
2011 |
|
Lung Neoplasms
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population.
|
16835333 |
2006 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicate that these tagSNPs of the ERCC2 and ERCC3 along with their surrounding regions may serve as biomarkers of susceptibility to lung cancer, which warrant further validation by other population-based and phenotypic studies to determine the biological relevance of these tagSNPs.
|
16835333 |
2006 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicate that these tagSNPs of the ERCC2 and ERCC3 along with their surrounding regions may serve as biomarkers of susceptibility to lung cancer, which warrant further validation by other population-based and phenotypic studies to determine the biological relevance of these tagSNPs.
|
16835333 |
2006 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicate that these tagSNPs of the ERCC2 and ERCC3 along with their surrounding regions may serve as biomarkers of susceptibility to lung cancer, which warrant further validation by other population-based and phenotypic studies to determine the biological relevance of these tagSNPs.
|
16835333 |
2006 |
|
Trichohepatoenteric Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The syndrome is also associated with mutations of the XPB, XPD and XPG genes.
|
16648759 |
2006 |
|
Esophageal Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
ERCC3 expression level was significantly correlated with the pathologic stage, tumor size and local invasiveness (t-factor) in esophageal cancer tissues.
|
15375507 |
2004 |