leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therapeutic targeting of USP9X led to preferential inhibition of the ERG-dependent leukemias.
|
31175119 |
2019 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
ERG-related leukemia is a B cell precursor acute lymphoblastic leukemia (BCP ALL) subtype characterized by aberrant expression of DUX4 and ERG transcription factors, and highly recurrent ERG intragenic deletions.
|
28415578 |
2017 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results illustrate a unique paradigm of transcription factor deregulation in leukemia in which DUX4 deregulation results in loss of function of ERG, either by deletion or induced expression of an isoform that is a dominant-negative inhibitor of wild-type ERG function.
|
27776115 |
2016 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data suggest that neither the expression of aberrant proteins from internally deleted allele nor the reduced expression of wild type ERG seem to provide a plausible explanation of the specific biology of ERG -related leukemia subgroup.
|
27494621 |
2016 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results support a model whereby a stem cell gene expression network driven by high ERG in human cells enhances the expansion of the progenitor pool, providing opportunity for the acquisition and propagation of mutations and the development of leukemia.
|
25306899 |
2015 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We hypothesize that ERG overexpression is associated with primary drug resistance thereby influencing the outcome in leukemia.
|
24504051 |
2014 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, integrative genomic analysis demonstrates that ERG causes myeloid progenitor leukemia characterized by an induction of leukemia stem cell transcriptional programs.
|
23974202 |
2013 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We investigated the regulation of ERG by microRNAs and explored their role in hematopoiesis and leukemia.
|
20570349 |
2011 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias.
|
21519790 |
2011 |
leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Moreover, the identification of a new ERG isoform (ERG3Deltaex12) suggests the association with different interaction partners and adds to the complexity of downstream pathways mediated by the expression of specific ERG transcripts in acute leukemia.
|
19108891 |
2009 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using this array, proof of principle was demonstrated by detection of known fusion genes (such as TCF3:PBX1, ETV6:RUNX1, and TMPRSS2:ERG) from all six positive controls consisting of leukemia cell lines and prostate cancer biopsies.
|
19152679 |
2009 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The proto-oncogene ERG in megakaryoblastic leukemias.
|
16140924 |
2005 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
We propose that trisomy 21 facilitates the occurrence of megakaryoblastic leukemias through a shift toward the megakaryoblastic lineage caused by the excess expression of ERG, and possibly by other chromosome 21 genes, such as RUNX1 and ETS2, in hematopoietic progenitor cells, coupled with a differentiation arrest caused by the acquisition of mutations in GATA1.
|
16140924 |
2005 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias.
|
9178886 |
1997 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, the TLS/FUS-ERG gene fusion in t(16;21) leukemia is predicted to produce a protein that is very similar to the EWS-ERG chimeric protein responsible for Ewing's sarcoma.
|
8187069 |
1994 |