ERG, ETS transcription factor ERG, 2078

N. diseases: 298; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Therapeutic targeting of USP9X led to preferential inhibition of the ERG-dependent leukemias. 31175119 2019
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE ERG-related leukemia is a B cell precursor acute lymphoblastic leukemia (BCP ALL) subtype characterized by aberrant expression of DUX4 and ERG transcription factors, and highly recurrent ERG intragenic deletions. 28415578 2017
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE These results illustrate a unique paradigm of transcription factor deregulation in leukemia in which DUX4 deregulation results in loss of function of ERG, either by deletion or induced expression of an isoform that is a dominant-negative inhibitor of wild-type ERG function. 27776115 2016
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE In conclusion, our data suggest that neither the expression of aberrant proteins from internally deleted allele nor the reduced expression of wild type ERG seem to provide a plausible explanation of the specific biology of ERG -related leukemia subgroup. 27494621 2016
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE These results support a model whereby a stem cell gene expression network driven by high ERG in human cells enhances the expansion of the progenitor pool, providing opportunity for the acquisition and propagation of mutations and the development of leukemia. 25306899 2015
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE We hypothesize that ERG overexpression is associated with primary drug resistance thereby influencing the outcome in leukemia. 24504051 2014
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Thus, integrative genomic analysis demonstrates that ERG causes myeloid progenitor leukemia characterized by an induction of leukemia stem cell transcriptional programs. 23974202 2013
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE We investigated the regulation of ERG by microRNAs and explored their role in hematopoiesis and leukemia. 20570349 2011
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias. 21519790 2011
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease CTD_human Moreover, the identification of a new ERG isoform (ERG3Deltaex12) suggests the association with different interaction partners and adds to the complexity of downstream pathways mediated by the expression of specific ERG transcripts in acute leukemia. 19108891 2009
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Using this array, proof of principle was demonstrated by detection of known fusion genes (such as TCF3:PBX1, ETV6:RUNX1, and TMPRSS2:ERG) from all six positive controls consisting of leukemia cell lines and prostate cancer biopsies. 19152679 2009
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE The proto-oncogene ERG in megakaryoblastic leukemias. 16140924 2005
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease LHGDN We propose that trisomy 21 facilitates the occurrence of megakaryoblastic leukemias through a shift toward the megakaryoblastic lineage caused by the excess expression of ERG, and possibly by other chromosome 21 genes, such as RUNX1 and ETS2, in hematopoietic progenitor cells, coupled with a differentiation arrest caused by the acquisition of mutations in GATA1. 16140924 2005
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias. 9178886 1997
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Thus, the TLS/FUS-ERG gene fusion in t(16;21) leukemia is predicted to produce a protein that is very similar to the EWS-ERG chimeric protein responsible for Ewing's sarcoma. 8187069 1994