Familial lichen amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, its relation to PTEN and ERG in localized PCA remains unclear.
|
27738792 |
2017 |
Familial lichen amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Data on TMPRSS2-ERG and AR-V7 may pave the way for personalised therapy for prostate cancer (PCa) patients.
|
26070514 |
2016 |
Familial lichen amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
AMACR expression was investigated in a cohort of 218 men with localized PCA treated by radical prostatectomy and correlated with ERG and various clinical and pathological parameters.
|
27271990 |
2016 |
Familial lichen amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that PTEN loss occurs in cooperation with TMPRSS2-ERG fusion in PCA.
|
26424596 |
2016 |
Familial lichen amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Approximately 50% of prostate cancer (PCa) patients in Western countries harbor ERG rearrangement with concurrent ERG overexpression.
|
24435928 |
2014 |
Familial lichen amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Functional biology analysis documented phenylalanine metabolism as the most significant pathway governing high CRISP3 and ERG expression in this subtype of PCA.
|
24606912 |
2014 |
Familial lichen amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homologue (PTEN) deletions and EGFR family aberrations were characterized as potential biomarkers for prostate cancer (PCa) patient management.
|
24516518 |
2014 |
Familial lichen amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
An ERG-like 10-gene signature was identified and validated in PCA cohorts of the physician health study (p115) (n = 110) in addition to three independent public datasets, and was significantly associated with disease progression, biochemical recurrence and PCA-specific mortality.
|
24006850 |
2014 |
Familial lichen amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Regional biases in the presentation of a well-known TMPRSS2-ERG fusion was noted in one PCA and the somatic mutation- and copy number-based phylogenetic relationships between intratumoural biopsies were largely concordant.
|
24870262 |
2014 |
Familial lichen amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Chromosomal translocations that juxtapose the androgen-sensitive transmembrane protease, serine 2 (TMPRSS2) gene promoter to the oncogenic ETS-family transcription factor ERG result in excessive ERG overexpression in approximately 50% of prostate cancer (PCa) patients.
|
24186205 |
2014 |
Familial lichen amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ERG protein expression was investigated in a cohort of 312 men with PCA diagnosed in transurethral resection of the prostate.
|
22300588 |
2012 |
Familial lichen amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homologue (PTEN) deletions and serine protease inhibitor Kazal type 1 (SPINK1) overexpression were investigated as potential markers for molecularly subtyping prostate cancer (PCA).
|
22260502 |
2012 |
Familial lichen amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A striking observation was that ERG and ETV-1 were found to be up-regulated in the glands of the PZ compared to the TZ, particularly when considering that ERG and ETV-1 fusions account for 50-80% and 20% of PCA occurrences, respectively.
|
22038307 |
2012 |
Familial lichen amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We interrogated 54 unsuspected PCA tumors using fluorescence in-situ hybridization for ERG rearrangements and PTEN deletions.
|
21178509 |
2011 |
Familial lichen amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The T-allele of the Met160Val variant in TMPRSS2, which has been associated with the TMPRSS2-ERG fusion, may be informative of time to PCA diagnosis for a subset of high-risk Caucasian men who are undergoing regular PCA screening.
|
20735386 |
2011 |
Familial lichen amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The incidences of ERG rearrangements and PTEN deletions in PCA were significantly higher than in high-grade prostatic intra-epithelial neoplasia (HGPIN) and benign prostate tissue (P < 0.001).
|
20590547 |
2011 |
Familial lichen amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We sought to characterize the incidence, pathological features and clinical parameters of TMPRSS2-ERG gene fusion in a cohort of 196 Canadian men treated by radical prostatectomy for localized PCA, and to investigate its potential as a biomarker in PCA.
|
19029822 |
2009 |
Familial lichen amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
If we consider the high incidence of PCA and the high frequency of this gene fusion, TMPRSS2-ERG is the most common genetic aberration so far described in human malignancies.
|
17527075 |
2007 |