Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 Biomarker disease BEFREE The aims of this study were (1) to present the diverse clinicopathological and molecular profile of EFTs in our settings, (2) to identify a pragmatic approach for diagnosing EFTs, especially for application of ancillary techniques, namely RT-PCR for specific transcripts (EWS-FLI1, EWS-ERG) and FISH for EWSR1 gene rearrangement, in certain cases and (3) to show the utility of tissue microarray in establishing a new FISH test. 24293381 2014
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 Biomarker disease BEFREE An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias. 21519790 2011
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 Biomarker disease BEFREE The detection of the EWS-FLI1 (20/25) and EWS-ERG (4/25) fusion transcripts resolved 24 of 25 cases of Ewing sarcoma/PNET. 20231617 2010
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 Biomarker disease BEFREE To apply these molecular markers to commonly available archival materials, we evaluated the feasibility of detecting EWS-Ets including EWS-Fli1 and EWS-ERG fusion transcripts in paraffin-embedded tissues and its diagnostic value for detecting ES/pPNET. 16157025 2005
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 GeneticVariation disease BEFREE Ewing sarcoma (ES) and peripheral primitive neuroectodermal tumors (PNETs) are associated with a chromosomal translocation resulting in a fusion of the amino-terminus of EWS with the DNA-binding domain of an ETS transcription factor (most commonly FLI1 or ERG). 12557222 2003
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 GeneticVariation disease BEFREE The method might also accurately diagnose ET-associated translocations other than EWS-FLI and EWS-ERG translocations. 11471459 2001
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 GeneticVariation disease BEFREE A novel EWS-ERG rearrangement generating two hybrid mRNAs in a peripheral primitive neuroectodermal tumour (pPNET) with a t(15;22) translocation. 10209495 1998
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 Biomarker disease BEFREE The presence of specific EWS-FLI1 or EWS-ERG transcripts in peripheral blood (PB) samples of patients being treated for ET was prospectively evaluated, and these data were correlated to their clinical status. 9836070 1998
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 GeneticVariation disease BEFREE Most Ewing tumors (ET), including Ewing sarcomas, peripheral primitive neuroectodermal tumors (PNET), and Askin's tumors, can be defined according to the specific chromosomal translocations t(11;22)(q24;q12) (EWS-FLI-1) or t(21;22)(q21;q12) (EWS-ERG). 9646032 1998
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 GeneticVariation disease BEFREE Ewing sarcoma and other peripheral primitive neuroectodermal tumors (pPNETs) display limited neural differentiation and are thought to have a neural crest origin Greater than 95% of these tumors share common t(11;22)(q24;q12) ort(21;22)(q22;q12) chromosomal translocations leading to ES/FLI1 or EWS/ERG gene fusions, respectively. 9496833 1998
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 GeneticVariation disease BEFREE The cytogenetic hallmark of the Ewing family of tumors is t(11,22)(q24;q12) in its simple, complex or variant forms and/or its molecular equivalent EWS/FLI, EWS/ERG rearrangement. 9049824 1997
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 GeneticVariation disease BEFREE The pPNETs show t(11;22)(q24;q12) or t(21;22)(q22;q12) chromosomal translocations fusing the EWS gene from 22q12 with either the FL11 gene on 11q24 or the ERG gene on 21q22. 8577710 1996
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 AlteredExpression disease BEFREE We detected 2 types of EWS-ERG chimeric mRNA in 2 ES cell lines and 1 PNET tumor sample in addition to 4 types of EWS-FLI-1 chimeric mRNA in 11 ESs (4 cell lines and 7 tumor samples) and 4 PNETs (2 cell lines and 2 tumor samples). 7591257 1995
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
0.100 GeneticVariation disease BEFREE Greater than 95% of pPNETs carry t(11;22) or t(21;22) chromosomal translocations which fuse the EWS gene from chromosome 22q12 in-frame with either FLI1 from chromosome 11q24 or ERG from chromosome 21q22. 7882340 1995