Anoxemia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Comparative proteomic profiles of the hepatopancreas in Fenneropenaeus chinensis response to hypoxic stress.
|
19579223 |
2009 |
Anoxia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Comparative proteomic profiles of the hepatopancreas in Fenneropenaeus chinensis response to hypoxic stress.
|
19579223 |
2009 |
Degenerative polyarthritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance.
|
18784066 |
2009 |
Osteoarthrosis Deformans
|
0.300 |
Biomarker
|
disease |
CTD_human |
Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance.
|
18784066 |
2009 |
Hypoxia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Comparative proteomic profiles of the hepatopancreas in Fenneropenaeus chinensis response to hypoxic stress.
|
19579223 |
2009 |
Hypoxemia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Comparative proteomic profiles of the hepatopancreas in Fenneropenaeus chinensis response to hypoxic stress.
|
19579223 |
2009 |
Hepatolenticular Degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rare allelic variants in ESD and INO80 increased and decreased chances for the neurological phenotype, respectively, while rare variants in APOE and MBD6 decreased the chances of WD early manifestation.
|
30230192 |
2019 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The esterase D (ESD) gene maps at a similar location as the RB gene locus and therefore serves as a potential marker for the prognosis of retinoblastoma.
|
19126594 |
2009 |
Hepatolenticular Degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In Chinese there is a tight linkage between WD and two gene loci for esterase D and retinoblastoma in the long arm of chromosome 13.
|
8410043 |
1993 |
Hepatolenticular Degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Wilson disease locus has been mapped to 13q and is closely linked to the esterase D and retinoblastoma genes.
|
8432554 |
1993 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In Chinese there is a tight linkage between WD and two gene loci for esterase D and retinoblastoma in the long arm of chromosome 13.
|
8410043 |
1993 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, esterase D and retinoblastoma, tightly linked in the mouse and human genomes, are not found to be closely linked in the canine genome.
|
8432554 |
1993 |
Hepatolenticular Degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have analyzed the segregation of esterase D (ESD) and retinoblastoma (RB) gene loci in ten families of Chinese WD subjects living in Taiwan.
|
1679032 |
1991 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ESD in conjunction with RB polymorphism would be useful in prenatal and presymptomatic diagnosis, as well as in carrier detection in informative pedigrees.
|
1679032 |
1991 |
Hepatolenticular Degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Linkage of the WD locus (WND) to ESD at 13q14 was first shown by studies in families of Middle Eastern origin using the isozymic polymorphism of esterase D. Using RFLPs detected by the ESD cDNA we could not confirm this reported close linkage in an analysis of 17 WD families of northwest European origin.
|
2227943 |
1990 |
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, it was recognition of both the deletion of band q14 of chromosome 13 in mentally retarded children with retinoblastoma, and the linkage of retinoblastoma with the genetic marker esterase D, which resulted in the eventual cloning of the gene.
|
2227145 |
1990 |
Hepatolenticular Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we carried out linkage analysis between three chromosome 13 DNA markers, D13S1, D13S10, D13S2, the locus for the red cell enzyme esterase D (ESD), and the Wilson's disease locus (WND) in 17 Wilson's disease families of Italian descent, mostly from Sardinia.
|
2563776 |
1989 |
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
With rhabdomyosarcoma metaphases, cDNA clones of the retinoblastoma susceptibility gene (RB1) and the esterase D gene (ESD), as well as the arbitrary genomic fragment 7D2 (D13S10), showed specific hybridization to the normal chromosome 13 and the der(2) marker, but not to the der(13).
|
2630183 |
1989 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results showed the importance of ESD studies in all retinoblastoma patients and their relatives.
|
2596526 |
1989 |
Hepatolenticular Degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The gene encoding human esterase D (EsD), a member of the nonspecific esterase family, is a useful genetic marker for retinoblastoma (RB) and Wilson's disease.
|
3164702 |
1988 |
Hepatolenticular Degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The WD locus (WND) has previously been linked to esterase D (ESD) and localized to 13q14-22.
|
3189332 |
1988 |
Hepatolenticular Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have used esterase D and several polymorphic markers on 13q to investigate linkage in WD pedigrees from the United States and Canada.
|
3163469 |
1988 |
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The breakpoint in this patient therefore must have occurred between the ESD gene and the retinoblastoma (Rb) predisposition locus.
|
3198126 |
1988 |
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
So, the conclusion might be drawn that screening of all retinoblastoma patients for esterase D in order to get insight in the weighting of risk of retinoblastoma is very much open to question and due to high cost efficiency ratio might not be recommended.
|
3164261 |
1988 |