|
Dwarfism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Estradiol and estrogen receptor α in the mPOA and MeA in dwarf hamster (Phodopus campbelli) fathers.
|
31816282 |
2020 |
|
Pneumonia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Estrogen, a major female sex steroid mediates its role through estrogen receptors (ER) ERα and ERβ, which are shown to be expressed in human ASM, and their expression is upregulated in lung inflammation and asthma.
|
31617730 |
2020 |
|
Turcot syndrome (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
MMR deficiency is significantly associated with inferior overall (HR 2.29, 95% CI 1.02-5.17, p = 0.040) and disease-specific survival (HR 2.71, 95% CI 1.00-7.35, p = 0.042) in the 431 estrogen receptor-positive patients who were uniformly treated with tamoxifen as their sole adjuvant systemic therapy.
|
31522348 |
2020 |
|
Pouchitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Secondary outcomes included decrease in total Pouchitis Disease Activity Index (PDAI) Score ≥ 3 at week 4, bowel movement frequency, ESR, CRP, fecal calprotectin, abdominal pain, and PDAI subscores including endoscopic and histologic changes.
|
31302808 |
2020 |
|
SCAPULOPERONEAL MYOPATHY, X-LINKED DOMINANT
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The risk of SPM was significantly related to the following demographical and clinical variables: age (40-59 vs. 18-39, HR = 1.33; 60-79 vs. 18-39, HR = 2.39; ≥80 vs. 18-39, HR = 2.84), race (black vs. white, HR = 1.12), histological type (lobular BC vs. ductal BC, HR = 1.15), radiotherapy (HR = 1.33), marital status (married vs. single, HR = 0.88) and estrogen receptor status (positive vs. negative, HR = 0.85).
|
30861567 |
2020 |
|
Coronary microvascular dysfunction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Coronary Microvascular Dysfunction and Estrogen Receptor Signaling.
|
31787492 |
2020 |
|
Pneumonitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Estrogen, a major female sex steroid mediates its role through estrogen receptors (ER) ERα and ERβ, which are shown to be expressed in human ASM, and their expression is upregulated in lung inflammation and asthma.
|
31617730 |
2020 |
|
Juvenile rheumatoid arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Early systematic monitoring of AAA at 3M may, therefore, guide drug switching in these patients.Key Points• Anti-adalimumab antibodies (AAA) production kinetics demonstrated a timely significant increase starting at 3M in juvenile idiopathic arthritis (JIA) patients under adalimumab therapy• Female gender, increased ESR, and leflunomide use were identified as relevant risk factors for AAA production in JIA, whereas methotrexate was protective.
|
31707543 |
2020 |
|
Abdominal Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Risk factors for the development of nephritis were age ≥ 8 years, atypical distribution of purpura, ESR > 20 mm/h and abdominal pain.
|
30895528 |
2019 |
|
Abscess
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Parameters including the operation time, blood loss, time of ESR and CRP decreasing to the normal level, time of abscess disappearance, time of bone graft fusion, rate of surgical complications, Visual Analog Scale (VAS) score, kyphosis angle and SF-36 scale were compared between two groups to evaluate their therapeutic effects.
|
31775707 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we investigated associations of estrogen receptor 1 (ESR1) genetics and serum estradiol activities with aspects of alcohol dependence.
|
30677468 |
2019 |
|
Alexithymia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
A statistical significant association was observed between alexithymia and inflammatory indices (ESR: P = .029, CRP: P = .043) and between alexithymia and clinimetric parameters (ptVAS, pVAS, GH, P < .0001 for all comparisons).
|
30681555 |
2019 |
|
Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Reduction of CRP from 1.7 [0.4-3.2] to 0.11 [0.05-0.5] mg/dL (p < 0.0001), ESR from 33 [14.5-61] to 6 [2-12] mm/1st hour (p < 0.0001) and decrease in patients with anemia from 16.4% to 3.8% (p < 0.0001) were observed.
|
30655091 |
2019 |
|
Arteriovenous fistula
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
This article of the European Dialysis (EUDIAL) Working Group of ERA-EDTA critically reviews the current evidence on VA in elderly haemodialysis patients and concludes that a pragmatic patient-centred approach is mandatory, thus considering the possibility that the AVF first approach should not be an absolute.
|
30339192 |
2019 |
|
Behcet Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, no difference of CRP (P = 0.219) or ESR (P = 0.320) between AAD patients and controls was observed, and no correlation of CRP (R = -0.150, P = 0.377) or ESR (R = 0.067, P = 0.692) with ascending aortic diameter in total BD patients was discovered either.
|
30101545 |
2019 |
|
Bloom Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Rationale:</b> The relevance of hormones in idiopathic pulmonary fibrosis (IPF), a predominantly male lung disease, is unknown.<b>Objectives:</b> To determine whether the ER (estrogen receptor) facilitates the development of pulmonary fibrosis and is mediated in part through microRNA regulation of ERα and ERα-activated profibrotic pathways.<b>Methods:</b> ER expression in male lung tissue and myofibroblasts from control subjects (<i>n</i> = 6) and patients with IPF (<i>n</i> = 6), aging bleomycin (BLM)-treated mice (<i>n</i> = 7), and BLM-treated AF2ERKI mice (<i>n</i> = 7) was determined.
|
31291549 |
2019 |
|
Intracranial Aneurysm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Four genes related to the estrogen receptor pathway were significantly associated with intracranial aneurysms, 2 of which were downregulated (PIK3R1: fold change [FC] = 0.41, false discovery rate [FDR] = 6.1 × 10<sup>-5</sup>, ADCY9: FC = 0.55, FDR = 2.3 × 10<sup>-4</sup>) and 2 of which were upregulated (HBEGF: FC = 1.46, FDR = 4.9 × 10<sup>-4</sup>; ADCY7: FC = 2.11, FDR = 6.0 × 10<sup>-3</sup>).
|
30831289 |
2019 |
|
Chondrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
While MELTVRs morphologically resemble soft tissue myoepitheliomas and extraskeletal myxoid chondrosarcomas, they have a unique immunohistochemical profile (positive for epithelial membrane antigen and estrogen receptor, negative for S100 protein and glial fibrillary acidic protein, and loss of INI1/SMARCB1 expression), and lack EWSR1 and NR4A3 gene rearrangement, as seen by fluorescence in situ hybridization.
|
30737997 |
2019 |
|
Dejerine-Sottas Disease (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
At week 2, E2 administration to AOM/DSS-treated OVX mice attenuated the histological severity of colitis by decreasing the protein and/or mRNA levels of estrogen receptor alpha (ERα) and NF-κB-related mediators (i.e., COX-2, TNF-α, and IL-6) and by enhancing estrogen receptor beta (ERβ) and nuclear Nrf2 protein expression and the mRNA expression of related antioxidant enzyme genes (i.e., HO-1, GCLC, GCLM, and NQO1).
|
30981879 |
2019 |
|
Dental caries
|
0.010 |
Biomarker
|
disease |
BEFREE |
To evaluate whether genetic polymorphisms in the genes that codify the ERα (ESR1) and GHR are associated with caries experience and DDE in children.
|
30341791 |
2019 |
|
Dysautonomia, Familial
|
0.010 |
Biomarker
|
disease |
BEFREE |
It has been previously reported that a restriction fragment length polymorphism in the gene encoding the vitamin D receptor (VDR) and the number of thymine-adenine (TA) repeats in the gene encoding the estrogen receptor alpha (ESR1) may each be associated with determinants of bone mineral density and may thus predict the development of osteoporosis across a number of non-FD populations.
|
28161223 |
2019 |
|
Eclampsia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis was performed in order to determine the associations between the estrogen receptor α (ESR1) gene PvuII site (-397T/C, rs2234693) and XbaI site (-351A/G, rs9340799) polymorphisms with severe and mild pre-eclampsia.
|
30630878 |
2019 |
|
Fibromyalgia
|
0.010 |
Biomarker
|
disease |
BEFREE |
RA patients with FM had higher DAS28-ESR, CDAI, PGA, and VAS compared with those without FM.
|
31377829 |
2019 |
|
Hunger
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Energy restriction during the Hunger Winter increased the estrogen receptor-negative BC risk regardless of the timing of energy restriction.
|
30252931 |
2019 |
|
Hyponatremia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
To obtain a common and holistic view, the European Society of Intensive Care Medicine (ESICM), the European Society of Endocrinology (ESE) and the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA), represented by European Renal Best Practice (ERBP), have developed clinical practice guidelines on the diagnostic approach and treatment of hyponatremia as a joint venture of 3societies representing specialists with a natural interest in hyponatremia.
|
28619670 |
2019 |