Osteopenia
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
Osteopenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Bone loss in these patients may be due to deficient ER-alpha protein expression.
|
10773580 |
2000 |
Osteopenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Estrogen receptor alpha polymorphism as a genetic marker for bone loss, vertebral fractures and susceptibility to estrogen.
|
11886765 |
2002 |
Osteopenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Estrogen receptor alpha CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women.
|
17896124 |
2008 |
Osteopenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, the rate of bone loss is accelerated in ovariectomized, estrogen-deficient gal-8 Tg mice, whereas gal-8 KO mice, having low levels of ESR1, are refractory to ovariectomy.
|
29259034 |
2018 |
Osteopenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Dehydrodiconiferyl Alcohol Inhibits Osteoclast Differentiation and Ovariectomy-Induced Bone Loss through Acting as an Estrogen Receptor Agonist.
|
29869503 |
2018 |
Osteopenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Estrogen and the estrogen receptor (ER) play a central role in bone metabolism as illustrated by the loss of bone mass after menopause and the osteopenia in individuals with defect aromatase or ER.
|
11092403 |
2000 |
Osteopenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, the ER-alpha (but not ER-beta) genotypes did modulate the previously described relationships between BMD or rates of bone loss and bioavailable estradiol (E(2)) levels in these men.
|
15070949 |
2004 |
Osteopenia
|
0.500 |
Biomarker
|
disease |
CTD_human |
Impact on bone of an estrogen receptor-alpha gene loss of function mutation.
|
18505767 |
2008 |
Osteopenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we could not demonstrate any major effect of the ER gene polymorphisms on BMD or rate of bone loss in healthy postmenopausal Danish women.
|
10678404 |
2000 |
Osteopenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
In multivariable analysis, only higher body mass index (OR 0.6 per 5kg/m<sup>2</sup>, 95% CI: 0.4-0.7) and nonwhite race compared to white (OR 0.5, 95% CI: 0.2-0.9) were protective for bone loss while older age (OR 1.5 per 10years, 95% CI: 1.1-2.1) and selective estrogen receptor modulator use (3.1, 95% CI: 1.2-10.1) were associated with increased odds of bone loss.
|
29422346 |
2018 |
Osteopenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Inactivation of estrogen receptor α in bone-forming cells induces bone loss in female mice.
|
23073829 |
2013 |
Osteopenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Osteoclast-specific HIF1α inactivation antagonized bone loss in Ovx mice and osteoclast-specific estrogen receptor alpha deficient mice, both models of estrogen-deficient osteoporosis.
|
24023068 |
2013 |
Osteopenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in the CYP19A1 (aromatase) gene influence disease-free survival and bone loss in patients taking aromatase inhibitors (AIs) for estrogen receptor-positive (ER+) breast cancers.
|
26049585 |
2015 |
Osteopenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Previous studies have revealed that ICA exerted a protective effect against bone loss and increased bone regeneration; however, the association between ICA and estrogen receptor (ER) signaling remains unclear.
|
30066871 |
2018 |
Osteopenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Selective estrogen receptor modulators and the vitamin D analogue eldecalcitol block bone loss in male osteoporosis.
|
27974229 |
2017 |
Osteopenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The ERA polymorphism was significantly associated with bone loss from the distal forearm (P = 0.04) but not with bone loss from the spine.
|
16735942 |
2006 |
Osteopenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The ESR1 variant allele was significantly higher in the osteopenia group when compared with women in the normal group (P = 0.02).
|
26634548 |
2015 |
Osteopenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The estrogen receptor (ER) mixed agonists tamoxifen and raloxifene have been shown to protect against bone loss in ovariectomized rats.
|
9275080 |
1997 |
Osteopenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The genes coding for estrogen receptor-alpha (ER-alpha) and androgen receptors (AR) are potential candidates for the regulation of bone mass and turnover, which may contribute to both the achievement of peak bone mass and bone loss after completion of growth.
|
15827868 |
2005 |
Osteopenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects against estrogen-deficient bone loss.
|
28768649 |
2017 |
Osteopenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
There was a significant association between a common haplotype "px", defined by the PvuII and XbaI restriction fragment length polymorphisms within intron 1 of the ESR1 gene, and femoral neck bone loss in postmenopausal women who had not received hormone replacement therapy (n = 945; p = 0.009).
|
15744038 |
2005 |
Osteopenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that the prevention from the ovariectomy-induced bone loss by estrogen is mediated by ER pathways and that the maintenance of BMD before ovariectomy might be compensated by other mechanisms distinct from ERalpha and ERbeta pathways.
|
10806217 |
2000 |
Osteopenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that the PvuII and the XbaI polymorphisms of ESR1 gene are associated with bone mineral density in premenopausal women with GD and may help to estimate the risk of bone loss particularly at lumbar spine.
|
21423915 |
2011 |
Osteopenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, a male carrying homozygous mutations in the ER-alpha gene and two males with homozygous mutations in the aromatase gene had osteopenia, unfused epiphyses, and elevated indices of bone turnover.
|
11730247 |
2001 |