|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In comparison with other biologics, patients receiving etanercept appeared to have a lower risk of depression.Key Points• Rheumatoid arthritis patients possessed higher risk of depression and anxiety.• Both depression and anxiety are strongly correlated with the subjective components of DAS28-ESR.• Etanercept might be the choice of biologics in rheumatoid arthritis patients with depression.
|
31823143 |
2020 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The estrogen receptor (ER) mechanisms by which 17β-estradiol influences depressive-like behaviour have primarily been investigated acutely and not within an animal model of depression.
|
31790664 |
2020 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Depression in these patients increased the release of pro-inflammatory cytokines that generate more autoantibodies and show strong binding with 16α‑OHE<sub>1</sub>-ER.
|
30500622 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Likewise, we observed no significant associations between clinical depression or antidepressant use and risk of <i>in situ</i>, ER<sup>+</sup>, ER<sup>-</sup>, premenopausal, or postmenopausal breast cancer.<b>Conclusions:</b> In the largest prospective study to date, we find no evidence that either depression or antidepressant use increase risk of breast cancer.<b>Impact:</b> The results of this study are reassuring in that neither depression nor antidepressant use appear to be related to subsequent breast cancer risk.
|
29263188 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The main predictors of achievement of inactive disease, calculated with Cox-regression models, were CRP≤82.0 mg/l (OR=7.9, HR=1.17), ESR≤32 mm/h (OR=17.0, HR=0.85), ferritin ≤273 ng/ml (OR=56.5, HR=2.6), Hb>113 g/l (OR=17.0, HR=1.33), LDH≤676 U/l (OR=113.6, HR=3.2), PLT>335*109/l (OR=5.0, HR=2.5), and intensive depression of WBC in 2 weeks after the 1st TCZ infusion>11% (OR=13.0, HR=6.0) and granulocytes>12% (OR=14.0, HR=4.7).
|
29303703 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Patients with a history of depression or reporting symptoms of depression according to the EuroQol five-dimension scale showed reduced improvement in tender and swollen joints, patient global assessment and ESR over 1-year follow-up.
|
29447376 |
2018 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Patients with depression had significantly worse disease activity, including higher BASDAI by 1.4 units (95% CI 1.0 to 1.9), ASDAS by 0.5 units (95% CI 0.3 to 0.7) and ESR by 3.5 mm/h (95% CI 0.6 to 6.4).
|
29996916 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
We identify estrogen receptor α (ERα) as the top regulator of pro-resilient transcriptional changes in the nucleus accumbens (NAc), a key brain reward region implicated in depression.
|
29549264 |
2018 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The first aim of this case-control study was to investigate whether variants in the two estrogen receptor genes might contribute to the genetic susceptibility to pregnancy-related depression using controls that were screened for postnatal depression.
|
29636617 |
2018 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the effects of antidepressant (AD) fluoxetine (FLU) treatment on the mitochondrial ER alpha (ERα), ER beta (total and phospho-pERβ) and their association with cytochrome c (cyt c) oxidase activity and apoptotic Bcl2/Bax-molecules in the hippocampal mitochondria of chronically isolated (CPSI) female and male rats depicting depression.
|
28716632 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, the role of estrogen receptor (ER) subtypes, ERα and ERβ, in the regulation of brain-derived neurotrophic factor (BDNF) and serotonin (5-HT) signaling was investigated; two pathways that have been hypothesized to be interrelated in the etiology of depression.
|
28544903 |
2017 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study was to explore the longitudinal changes of prevalence and severity of depression in 439 Chinese Han adolescents with different genotypes of ESR1 rs9340799 at 6, 12 and 18months after the 2008 Wenchuan earthquake.
|
28890035 |
2017 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study substantiates the involvement of the MAOA and MTHFR polymorphisms in climacteric depression and offers evidence that the COMT and ESR1 genes may also play a role in the susceptibility to depressive mood in postmenopausal women.
|
26620113 |
2016 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
History of post-menopausal hormone (PMH) use modified the association of ESR1 polymorphism RS2234693 with any lifetime depression; specifically, those with the TT allele had the highest risk of lifetime depression among PMH users, and the lowest risk of depression among non-PMH users (p value for interaction = 0.02).
|
26169989 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Logistic regression was used in age, body mass index, education, depression, hypertension, diabetes, history of stroke, smoking status, ApoE e4 carrier, and estrogen receptor a genotypes to calculate their odds ratios.
|
24133901 |
2013 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The association between two common estrogen receptor alpha (ESR1) polymorphisms with lifetime MDD was examined using adjusted logistic regression models, taking into account the age at first depressive episode and the recurrence of depression.
|
22051074 |
2012 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Estrogen receptor α and vitamin D receptor polymorphisms are not associated with depression or the response to intervention in older postmenopausal women.
|
22205149 |
2012 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Estrogen receptor α and vitamin D receptor polymorphisms are not associated with depression or the response to intervention in older postmenopausal women.
|
22205149 |
2012 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
This review provides a synthesis of studies that have examined the association between estrogen receptor polymorphisms and depression-related mood disorders across the lifetime.
|
22901010 |
2012 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
If it is confirmed that specific estrogen receptor polymorphisms are associated with the risk of depression, this could have important preventive and therapeutic implications, with the potential to develop targeted estrogen receptor agonists and antagonists.
|
22901010 |
2012 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Four-and-a-half-LIM protein 1 down-regulates estrogen receptor α activity through repression of AKT phosphorylation in human breast cancer cell.
|
22094188 |
2012 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The association between two common estrogen receptor alpha (ESR1) polymorphisms with lifetime MDD was examined using adjusted logistic regression models, taking into account the age at first depressive episode and the recurrence of depression.
|
22051074 |
2012 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In women, the ER-α rs2234693 and rs9340799 polymorphisms were significantly associated with the risk of late-life depression.
|
21804148 |
2011 |