ALAD, aminolevulinate dehydratase, 210

N. diseases: 135; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023176
Disease: Lead Poisoning
Lead Poisoning
0.500 Biomarker disease CTD_human Investigation of delta-aminolevulinic acid dehydratase polymorphism affecting hematopoietic, hepatic and renal toxicity from lead in Han subjects of southwestern China. 24631795 2014
CUI: C0023176
Disease: Lead Poisoning
Lead Poisoning
0.500 Biomarker disease CTD_human Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by δ-aminolevulinic acid dehydratase gene polymorphism. 23792432 2013
CUI: C0023176
Disease: Lead Poisoning
Lead Poisoning
0.500 Biomarker disease CTD_human The difference in methylation frequencies between exposures and controls was statistically significant (p=0.002), and individuals with methylated ALAD gene showed an increased risk of lead poisoning (adjusted OR=3.57, 95% CI, 1.55-8.18). 21396434 2011
CUI: C0023176
Disease: Lead Poisoning
Lead Poisoning
0.500 Biomarker disease RGD Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats. 19647414 2010
CUI: C0023176
Disease: Lead Poisoning
Lead Poisoning
0.500 Biomarker disease RGD Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats. 16597373 2006