Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Neurite shortening caused by the c.250G>A mutation in ETFDH suggests that neural defects could be underdiagnosed in human patients with MADD.
|
27935074 |
2017 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This case report extends the spectrum of ETFDH mutations in MADD, providing further evidence that patients presenting at least one missense mutation in the FAD-binding domain may respond to either carnitine or riboflavin treatment, due to the recovery of some enzymatic activity.
|
30424791 |
2018 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Urine organic acid analysis and mutation analysis of the ETFDH gene confirmed the diagnosis of MADD.
|
19783111 |
2010 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The research findings suggest that the majority of Chinese patients with RR-LSM are caused by a mild type of MADD with unique myopathy which is due to ETFDH gene mutation.
|
19758981 |
2010 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Recently, mutations in ETFDH were found to be responsible for all riboflavin-responsive MADD patients.
|
19265687 |
2009 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Multiple acyl-CoA-dehydrogenase deficiency (MADD)--a novel mutation of electron-transferring-flavoprotein dehydrogenase ETFDH.
|
21616504 |
2011 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
High resolution melting (HRM) analysis and sequencing of the entire ETFDH gene revealed a novel mutation (p.Phe128Ser) and the hotspot mutation (p.Ala84Thr) from a patient with MADD.
|
22013910 |
2011 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Late-onset multiple acyl-coenzyme A dehydrogenase deficiency (MADD) mainly affects the neck extensor muscle group, which has been confirmed by novel mutations in electron-transferring-flavoprotein dehydrogenase (ETFDH).
|
30508893 |
2018 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
Biomarker
|
disease |
BEFREE |
The electron-transfer flavoprotein dehydrogenase gene (<i>ETFDH</i>) that encodes the ETF-ubiquinone oxidoreductase (ETF-QO) has been reported to be the major cause of multiple acyl-CoA dehydrogenase deficiency (MADD).
|
30709034 |
2019 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In humans, mutations in electron transfer flavoprotein (ETF) or electron transfer flavoprotein dehydrogenase (ETFDH) lead to MADD/glutaric aciduria type II, an autosomal recessively inherited disorder characterized by a broad spectrum of devastating neurological, systemic and metabolic symptoms.
|
20020044 |
2009 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The late-onset MADD is frequently caused by mutations in ETFDH gene.
|
31136308 |
2019 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The novel variants in ETFDH and the corresponding clinical features enrich the variant spectrum of late-onset MADD and provide a new insight into the genotype-phenotype relationship.
|
27000805 |
2016 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
Biomarker
|
disease |
BEFREE |
Multiple acyl-CoA dehydrogenase deficiency (MADD) is an autosomal recessive disorder caused by deficiency of electron transfer flavoprotein or electron transfer flavoprotein dehydrogenase.
|
25200064 |
2014 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Classical multiple acyl-CoA dehydrogenase deficiency (MADD) is known to occur secondary to mutations in electron transfer flavoprotein dehydrogenase (ETFDH) gene.
|
29615056 |
2018 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
A novel ETFDH mutation in an adult patient with late-onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency.
|
28914566 |
2018 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The muscle biopsy showed lipid storage disorder; and compound heterozygous mutations in the electron transfer flavoprotein dehydrogenase (ETFDH) gene were found in the two patients through targeted next generation sequencing, which provided the definite diagnostic evidences of late-onset MADD.
|
30587156 |
2018 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Novel ETFDH mutation and imaging findings in an adult with glutaric aciduria type II.
|
23893693 |
2014 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Mutations in ETFDH, encoding ETF-QO have been associated with both riboflavin-responsive and non-responsive MADD as well as a myopathic form of CoQ(10) deficiency, although pathomechanisms responsible for these different phenotypes are not well-defined.
|
19249206 |
2009 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Recently, ETFDH mutations were reported to be major causes of riboflavin-responsive MADD.
|
20138856 |
2010 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In order to contribute to the elucidation of these mechanisms, we isolated mitochondria from cultured fibroblasts, from a patient with a severe MADD presentation due to ETF-QO deficiency, characterize its mitochondrial proteome and compare it with normal controls.
|
21596162 |
2011 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Tandem mass spectrometry detected multiple acyl-CoA deficiency, leading to the analysis of the electron-transferring-flavoprotein dehydrogenase (ETFDH) gene, previously shown to result in another metabolic disorder, glutaric aciduria type II (GAII).
|
17412732 |
2007 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Immunoblot analysis of electron-transferring-flavoprotein and its dehydrogenase electron-transferring-flavoprotein dehydrogenase led to mutation analysis of the ETFDH gene, which revealed two different pathogenic mutations in both alleles and confirmed the diagnosis of glutaric aciduria type 2 caused by electron-transferring-flavoprotein dehydrogenase deficiency.
|
20837308 |
2010 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We here present an analysis of the spectrum of ETFDH mutations in the largest cohort of patients with MADD (90 unrelated patients).
|
24357026 |
2014 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
A novel mutation in ETFDH manifesting as severe neonatal-onset multiple acyl-CoA dehydrogenase deficiency.
|
29249369 |
2018 |
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
To report mutations in ETFA, ETFB and ETFDH genes identified in Portuguese patients, correlating, whenever possible, biochemical and clinical outcomes with the effects of mutations on the structure and stability of the affected proteins, to better understand MADD pathogenesis at the molecular level.
|
31418342 |
2019 |