Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, these data indicate a novel and specific mechanism allowing ETS2 to switch between oncogenic and tumor suppressive functions in a cell-type specific manner.
|
28119415 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Analysis of clinicopathological characteristics showed that increased level of ETS2 is associated with III-IV tumor node metastasis stage and lymph node metastasis.
|
29111780 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our findings established that Ets2 is a tumor suppressor gene in prostate cancer, and its loss along with other genes within the TMPRSS2-ERG interstitial region contributes to disease progression.
|
26880803 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, in vivo, Xenograft mouse model studies showed Ets2 knockdown inhibits tumor formation and metastasis significantly.
|
27556183 |
2016 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Notably, ETS2 rs461155A>G was significantly associated with decreased ETS2 mRNA expression in both tumor and paired normal lung tissues (Ptrend = 4 × 10-7, and 3 × 10-4, respectively).
|
26893365 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings point to a tumor suppressor role for ETS2 in human NSCLC pathogenesis through inhibition of the MET proto-oncogene.
|
23659968 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Consistent with these results, PyMT and ErbB2 tumors lacking Ets2 in fibroblasts had fewer functional blood vessels, and Ets2 in fibroblasts elicited changes in gene expression in tumor endothelial cells consistent with this phenotype.
|
23977064 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data indicate that ETS2 plays a key role in controlling the expression of miR-196b, and miR-196b may mediate the tumor suppressor effects of ETS2.
|
22298639 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of the Pten-miR-320-Ets2-regulated secretome distinguished human normal breast stroma from tumour stroma and robustly correlated with recurrence in breast cancer patients.
|
22179046 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Consistent with these results, Ets2 ablation in TAMs led to decreased angiogenesis and decreased growth of tumors.
|
20145133 |
2010 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We demonstrate that CDK10 is an important determinant of resistance to endocrine therapies and show that CDK10 silencing increases ETS2-driven transcription of c-RAF, resulting in MAPK pathway activation and loss of tumor cell reliance upon estrogen signaling.
|
18242510 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Detailed technical analysis of urine RNA-based tumor diagnostics reveals ETS2/urokinase plasminogen activator to be a novel marker for bladder cancer.
|
17921261 |
2007 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Except for one patient who had C/C (in normal tissue) homozygotes to T/C (in tumour tissue) heterozygotes point mutation, a novel single nucleotide polymorphism (SNP) -245 kb upstream (Ets2 binding site) of the hTERT gene was observed in all normal and tumour tissues, including C/C in 9, T/C in 35, and T/T in 22 of the tumour tissues.
|
16737810 |
2006 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemistry analysis showed that the expression level of ETS2 protein rose in 75 % (12/16) tumor epithelial cells contrasted to the normal cells.
|
12532432 |
2003 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, we propose that MEF is a candidate tumor suppressor gene on the X chromosome with activities that are opposite to those of ETS-2.
|
12438253 |
2002 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Six of 10 cervical carcinoma cell lines overexpressed ets-2 RNA suggesting an association of overexpression with cervical cell neoplasia.
|
9174050 |
1997 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The c-ets-2 transfected cells formed colonies in semisolid medium and induced tumors in nude mice, indicating that c-ets-2 can be a transforming gene when overexpressed in these cells.
|
2813360 |
1989 |