|
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
ETV6/RUNX1 was found in 45% of cases and in the majority (10/18; 56%) of ALLs with sole +21.
|
16965388 |
2006 |
|
Acute lymphocytic leukemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The TEL-AML1 fusion protein of acute lymphoblastic leukemia modulates IRF3 activity during early B-cell differentiation.
|
25893288 |
2015 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Here we show that variant alleles of TLX1_rs2742038 and ETV6_rs1573613 were associated with increased risk of childhood ALL (OR (95% CI) = 3.97 (1.43-11.02) and 1.9 (1.16-3.11), respectively), while PML_rs9479 was associated with decreased ALL risk (OR = 0.55 (0.36-0.86).
|
24886876 |
2014 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Previous studies on concordant acute lymphoblastic leukemia (ALL) in identical twins have identified the leukemia as monoclonal with MLL or ETV6-RUNX1 gene fusion as early or initiating events in utero.
|
12800152 |
2003 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The ETV6/CBFA2 (TEL/AML1) fusion gene occurs as a result of the chromosome translocation t(12;21)(p13;q22) in up to 30% of children diagnosed with B cell precursor (cd10+, cd19+) acute lymphoblastic leukemia.
|
9050885 |
1997 |
|
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
This study identifies deletions of TBL1XR1 as a recurrent abnormality in ETV6-RUNX1 positive ALL.
|
18767146 |
2008 |
|
Acute lymphocytic leukemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
BCR-ABL1, TCF3-PBX1, KMT2A-AFF1 and ETV6-RUNX1 were more frequent in B-ALL.
|
30125757 |
2018 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Co-existence of multiple subclones in TEL-AML1 at diagnosis of acute lymphoblastic leukaemia in association with submicroscopic deletion of AML1.
|
15877731 |
2005 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Translocation (2;8)(p12;q24) associated with a cryptic t(12;21)(p13;q22) TEL/AML1 gene rearrangement in a child with acute lymphoblastic leukemia.
|
11106815 |
2000 |
|
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
This study was aimed to explore the METTL3 and METTL14 expressions in children with ETV6/RUNX1(E/R)-positive acute lymphoblastic leukemia (ALL) and investigate the relation between the METTL3 and METTL14 expressions with clinical features.
|
31429529 |
2019 |
|
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
This novel SNP array analysis in an extremely rare series of cases opens new ideas about the etiology of ETV6-RUNX1-positive ALL.
|
19665068 |
2009 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We previously cloned the PAX5/TEL fusion gene in a patient affected by B-cell precursor ALL with a t(9;12) translocation.
|
18172310 |
2008 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Intermediate and late relapses were more common in TEL-AML1(+) patients and other BCP-ALLs compared with other subgroups (P = 0.018).
|
22911440 |
2012 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two recently described molecular abnormalities in childhood ALL are ETV6 gene rearrangements and homozygous deletions of p16(INK4A) and/or p15(INK4B).
|
9204978 |
1997 |
|
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Common CNAs involved CDKN2A/2B (30.3%), IKZF1 (27.3%), PAX5 (9.1%), RB1 (9.1%), BTG1 (6.7%), and ETV6 (6.7%), which regulate cell cycle, B lymphopoiesis, or act as tumor suppressors in ALL.
|
31112375 |
2019 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Minimal residual disease monitoring in childhood B lymphoblastic leukemia with t(12;21)(p13;q22); ETV6-RUNX1: concordant results using quantitation of fusion transcript and flow cytometry.
|
28004528 |
2017 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Constitutional trisomy 21 is the most prominent predisposing factor to childhood leukemia, whereas the t(12;21)(p13;q22) with its molecular genetic counterpart, the TEL/AML1 fusion gene, is the most common acquired chromosomal rearrangement in childhood B-cell precursor (BCP) acute lymphoblastic leukemia (ALL).
|
16020107 |
2005 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Finally, we reviewed the literature for ETV6 germline aberrations and predispositions to ALL.
|
29034503 |
2018 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recurrent genetic abnormalities in B-lymphoblastic leukemia with prognostic significance are well known and specifically delineated in the WHO 2008 classification (eg hyperdiploidy, t(9;22)(q34;q11.2); BCR-ABL1, t(12;21)(p13;q22); ETV6-RUNX1).
|
21822204 |
2011 |
|
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
These data provide novel insight into the natural history of childhood leukemia and suggest that consequent to a prenatal initiation of a leukemic clone, most probably by TEL-AML fusion itself, the latency of ALL can be both extremely variable and protracted.
|
10419898 |
1999 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia.
|
25807284 |
2015 |
|
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
By assessing the expression of 82 genes involved in purine metabolism (KEGG pathway database) in ALL blasts from 38 patients with B-lineage ALL (14 with TEL-AML1, 24 without), we identified 16 genes that were differentially expressed in TEL-AML1-positive and TEL-AML1-negative ALL (P <.001, false discovery rate [FDR] = 5%).
|
15142881 |
2004 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Comparative incidence of the rearrangements of TEL/AML1 and ALL1 genes in pediatric precursor B acute lymphoblastic leukemias in India.
|
9824651 |
1998 |
|
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
|
15156184 |
2004 |
|
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thus we conclude that the TEL allele not involved in t(12;21) is inconstantly lost in patients with this subtype of ALL and occurs on the 12p- chromosome.
|
8558923 |
1996 |