|
Leukemia, Myelomonocytic, Chronic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Chronic myelomonocytic leukemia with ETV6-ABL1 rearrangement and SMC1A mutation.
|
31425923 |
2019 |
|
Leukemia, Myelomonocytic, Chronic
|
0.390 |
Biomarker
|
disease |
BEFREE |
Molecular cytogenetic findings in a four-way t(1;12;5;12)(p36;p13;q33;q24) underlying the ETV6-PDGFRB fusion gene in chronic myelomonocytic leukemia.
|
17574967 |
2007 |
|
Leukemia, Myelomonocytic, Chronic
|
0.390 |
Biomarker
|
disease |
BEFREE |
We tested its effectiveness against fusion tyrosine kinases TEL-platelet-derived growth factor receptorbeta (TEL-PDGFRbeta) and FIP1-like-1 (FIP1L1)-PDGFRalpha, which cause chronic myelomonocytic leukemia and hypereosinophilic syndrome, respectively.
|
16030188 |
2005 |
|
Leukemia, Myelomonocytic, Chronic
|
0.390 |
Biomarker
|
disease |
BEFREE |
Sensitivity to imatinib but low frequency of the TEL/PDGFRbeta fusion protein in chronic myelomonocytic leukemia.
|
12681968 |
2003 |
|
Leukemia, Myelomonocytic, Chronic
|
0.390 |
Biomarker
|
disease |
BEFREE |
Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF beta R fusion protein.
|
10597306 |
1999 |
|
Leukemia, Myelomonocytic, Chronic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
ETV6 was originally identified in a t(5;12)(q33;p13) occurring in a chronic myelomonocytic leukemia (CMML).
|
9031109 |
1996 |
|
Leukemia, Myelomonocytic, Chronic
|
0.390 |
Biomarker
|
disease |
BEFREE |
The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways.
|
8962143 |
1996 |
|
Leukemia, Myelomonocytic, Chronic
|
0.390 |
FusionGene
|
disease |
ORPHANET |
TEL gene is involved in myelodysplastic syndromes with either the typical t(5;12)(q33;p13) translocation or its variant t(10;12)(q24;p13).
|
7742547 |
1995 |
|
Leukemia, Myelomonocytic, Chronic
|
0.390 |
Biomarker
|
disease |
BEFREE |
These data show that TEL, previously shown to be fused to the platelet-derived growth factor receptor beta in chronic myelomonocytic leukemia, can be implicated in the pathogenesis of leukemia through its fusion to either a receptor tyrosine kinase or a transcription factor.
|
7761424 |
1995 |
|
Leukemia, Myelomonocytic, Chronic
|
0.390 |
Biomarker
|
disease |
BEFREE |
In addition to fusion of TEL to the PDGF beta receptor in t(5;12) in chronic myelomonocytic leukemia (CMML), our data suggest that the involvement of this protein in myeloid leukemogenesis could be dual; its isolated protein-protein dimerization and DNA-binding domains may be crucial for the oncogenic activation of functionally different fusion proteins.
|
7731705 |
1995 |
|
Leukemia, Myelomonocytic, Chronic
|
0.390 |
FusionGene
|
disease |
ORPHANET |
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation.
|
8168137 |
1994 |