|
Hematologic Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Care for individuals with ETV6-related thrombocytopenia and leukemia predisposition includes genetic counseling, treatment or prevention of excessive bleeding and surveillance for the development of hematologic malignancy.
|
31248877 |
2019 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
ETV6-ABL1 fusion is a rare but recurrent genetic aberration found in various hematologic malignancies involving both the lymphoid and myeloid lineage, but to the best of our knowledge, CMML is an exceptionally rare presentation of ETV6-ABL1 rearranged neoplasm.
|
31425923 |
2019 |
|
Hematologic Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Genetic alterations in the transcriptional repressor ETV6 are associated with hematological malignancies.
|
30341373 |
2018 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies.
|
29076873 |
2018 |
|
Hematologic Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Recently, autosomal dominant germline ETV6 mutations were discovered in families with inherited thrombocytopenia and a propensity to develop hematological malignancy, unequivocally demonstrating a role for ETV6 in leukemogenesis.
|
28637624 |
2017 |
|
Hematologic Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Leukemias harboring the ETV6-ABL1 fusion represent a rare subset of hematological malignancies with unfavorable outcomes.
|
28650474 |
2017 |
|
Hematologic Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Variants in ETV6, which encodes a transcription repressor of the E26 transformation-specific family, have recently been reported to be responsible for inherited thrombocytopenia and hematologic malignancy.
|
27663637 |
2017 |
|
Hematologic Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Germline ETV6 mutations and predisposition to hematological malignancies.
|
28555414 |
2017 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
To characterize the incidence, clinical features and genetics of ETV6-ABL1 leukemias, representing targetable kinase-activating lesions, we analyzed 44 new and published cases of ETV6-ABL1-positive hematologic malignancies [22 cases of acute lymphoblastic leukemia (13 children, 9 adults) and 22 myeloid malignancies (18 myeloproliferative neoplasms, 4 acute myeloid leukemias)].
|
27229714 |
2016 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
ETV6-related thrombocytopenia is an autosomal dominant thrombocytopenia that has been recently identified in a few families and has been suspected to predispose to hematologic malignancies.
|
27365488 |
2016 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Many fusion partners of ETV6 have been reported in a variety of epithelial and hematological malignancies.
|
26492182 |
2016 |
|
Hematologic Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.
|
25581430 |
2015 |
|
Hematologic Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.
|
25581430 |
2015 |
|
Hematologic Neoplasms
|
0.500 |
GeneticVariation
|
group |
CLINVAR |
Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.
|
25581430 |
2015 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
CTD_human |
Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.
|
25581430 |
2015 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
The ETV6 gene encodes an ETS family transcription factor that is involved in a myriad of chromosomal rearrangements found in hematological malignancies and other neoplasms.
|
26584717 |
2015 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
ETV6 fusion genes in hematological malignancies: a review.
|
22578774 |
2012 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
ETV6 is an important hematopoietic regulatory factor and ETV6 gene rearrangement is involved in a wide variety of hematological malignancies.
|
22373549 |
2012 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Alterations of the short arm of chromosome 12 (12p) occur in various hematologic malignancies and ETV6 and CDKN1B, which are located on 12p, have been implicated as leukemogenic genes of interest.
|
21422114 |
2011 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
This case reiterates the importance of correlating morphologic and phenotypic findings with the results of cytogenetic analysis to avoid errors in diagnosing hematologic neoplasms and highlights the rare association of B-cell non-Hodgkin lymphoma with aberrations of TEL.
|
18992913 |
2009 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
The ETV6 gene has been reported to be fused to a multitude of partner genes in various hematologic malignancies with 12p13 aberrations.
|
18281529 |
2008 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Fusion of ETV6 (ETS translocation variant 6, previously known as TEL) to ABL1 due to t(9;12) has been observed in various hematological malignancies.
|
18656692 |
2008 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
The ETV6 gene on 12p13 is involved in different hematologic malignancies through a variety of chromosomal translocations.
|
16757412 |
2006 |
|
Hematologic Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
HDAC9 interacts and co-localizes in vivo with a number of transcriptional repressors and co-repressors, including TEL and N-CoR, whose functions have been implicated in the pathogenesis of hematological malignancies.
|
12590135 |
2003 |
|
Hematologic Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
ETS variant gene 6 (ETV6)/translocation, ETS, leukemia (TEL)-involving chromosomal translocations are frequently observed in various hematologic neoplasms.
|
12764377 |
2003 |