|
Adult Malignant Peripheral Nerve Sheath Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Identification of a novel fusion transcript EWSR1-VEZF1 by anchored multiplex PCR in malignant peripheral nerve sheath tumor.
|
31812440 |
2020 |
|
Adult Epithelioid Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a pathogenetic sense, epithelioid soft tissue tumors basically fall into three main genetic categories: (1) switch/sucrose non-fermenting (SWI/SNF) complex-deficient tumors (with epithelioid sarcoma as their prototype); (2) epithelioid neoplasms driven by specific rare gene fusions (such as sclerosing epithelioid fibrosarcoma with EWSR1 fusions and GLI1-related malignant epithelioid soft tissue neoplasms); and (3) a heterogeneous group encompassing epithelioid variants of diverse other entities.
|
31686193 |
2020 |
|
Childhood Malignant Peripheral Nerve Sheath Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Identification of a novel fusion transcript EWSR1-VEZF1 by anchored multiplex PCR in malignant peripheral nerve sheath tumor.
|
31812440 |
2020 |
|
Childhood Epithelioid Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a pathogenetic sense, epithelioid soft tissue tumors basically fall into three main genetic categories: (1) switch/sucrose non-fermenting (SWI/SNF) complex-deficient tumors (with epithelioid sarcoma as their prototype); (2) epithelioid neoplasms driven by specific rare gene fusions (such as sclerosing epithelioid fibrosarcoma with EWSR1 fusions and GLI1-related malignant epithelioid soft tissue neoplasms); and (3) a heterogeneous group encompassing epithelioid variants of diverse other entities.
|
31686193 |
2020 |
|
Malignant Peripheral Nerve Sheath Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Identification of a novel fusion transcript EWSR1-VEZF1 by anchored multiplex PCR in malignant peripheral nerve sheath tumor.
|
31812440 |
2020 |
|
Brain Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
This will provide a better understanding of bona fide roles of EWSR1 in aging and its association with brain disorders.
|
30481590 |
2019 |
|
CNS disorder
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Recently, several studies have shown that missense mutations of EWSR1 genes are known to be associated with central nervous system disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
|
30481590 |
2019 |
|
Monosomy
|
0.010 |
Biomarker
|
group |
BEFREE |
Fluorescence in situ hybridization for EWSR1 demonstrated monosomy of 22q in greater than 90% of cells.
|
29944970 |
2019 |
|
Nervous System Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The role of EWSR1-ATF1 and MUTYH mutations in central nervous system tumours is not well established.
|
30642852 |
2019 |
|
Malignant neoplasm of testis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we found that EWSR1-FLI1 modulates the expression of cancer/testis (CT) antigen genes, whose expression is biased to the testes but is also activated in cancer.
|
31036566 |
2019 |
|
Liposarcoma, Dedifferentiated
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, the splicing events of certain STS key genes were significantly associated with STS 2-year overall survival in the present study, including exon skip (ES) events in MDM2 and EWSR1, alternate terminator events in CDKN2A and HMGA2 for dedifferentiated liposarcoma, ES in MDM2 and alternate promoter events in CDKN2A for leiomyosarcoma, and ES in EWSR1 for undifferentiated pleomorphic sarcoma.
|
31443718 |
2019 |
|
Adult Undifferentiated Pleomorphic Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, the splicing events of certain STS key genes were significantly associated with STS 2-year overall survival in the present study, including exon skip (ES) events in MDM2 and EWSR1, alternate terminator events in CDKN2A and HMGA2 for dedifferentiated liposarcoma, ES in MDM2 and alternate promoter events in CDKN2A for leiomyosarcoma, and ES in EWSR1 for undifferentiated pleomorphic sarcoma.
|
31443718 |
2019 |
|
Inflammatory Myofibroblastic Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This review addresses three main neoplastic categories that are associated with specific paraneoplastic phenomena: (1) neoplasms having in common the presence of diffuse mixed inflammatory infiltration (closely simulating an inflammatory pseudotumor) and frequently associated with constitutional symptoms; (2) neoplasms with undifferentiated, anaplastic or rhabdoid cell morphology (frequently SWI/SNF-deficient) associated with diverse paraneoplastic manifestations; and (3) paraneoplasia associated with neoplasms carrying specific gene fusions such as solitary fibrous tumor (STAT6-NAB2 gene fusions), infantile fibrosarcoma and congenital mesoblastic nephroma (ETV6-NTRK3 gene fusions), and angiomatoid fibrous histiocytoma (EWSR1-CREB1 & EWSR1-ATF1 fusions).
|
30819530 |
2019 |
|
Malignant Fibrous Histiocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, the splicing events of certain STS key genes were significantly associated with STS 2-year overall survival in the present study, including exon skip (ES) events in MDM2 and EWSR1, alternate terminator events in CDKN2A and HMGA2 for dedifferentiated liposarcoma, ES in MDM2 and alternate promoter events in CDKN2A for leiomyosarcoma, and ES in EWSR1 for undifferentiated pleomorphic sarcoma.
|
31443718 |
2019 |
|
Recurrent tumor
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We present a case of EWSR1-SMAD3 positive fibroblastic tumor that occurred in a 24-year-old man who presented with a recurrent tumor in the dorsum of his right foot.
|
31376366 |
2019 |
|
Solitary fibrous tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This review addresses three main neoplastic categories that are associated with specific paraneoplastic phenomena: (1) neoplasms having in common the presence of diffuse mixed inflammatory infiltration (closely simulating an inflammatory pseudotumor) and frequently associated with constitutional symptoms; (2) neoplasms with undifferentiated, anaplastic or rhabdoid cell morphology (frequently SWI/SNF-deficient) associated with diverse paraneoplastic manifestations; and (3) paraneoplasia associated with neoplasms carrying specific gene fusions such as solitary fibrous tumor (STAT6-NAB2 gene fusions), infantile fibrosarcoma and congenital mesoblastic nephroma (ETV6-NTRK3 gene fusions), and angiomatoid fibrous histiocytoma (EWSR1-CREB1 & EWSR1-ATF1 fusions).
|
30819530 |
2019 |
|
Extrarenal rhabdoid tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
In light of the unusual findings in this case as well as the proximity of the EWSR1 locus and SMARCB1 locus on chromosome 22 and frequent CD99 staining in both tumors, we examined 16 ES cases and 17 ATRT, renal rhabdoid tumor (RRT), and extrarenal rhabdoid tumor (ERRT) cases for CD99 and INI1 staining and for EWSR1 rearrangement.
|
28382842 |
2019 |
|
Congenital Mesoblastic Nephroma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This review addresses three main neoplastic categories that are associated with specific paraneoplastic phenomena: (1) neoplasms having in common the presence of diffuse mixed inflammatory infiltration (closely simulating an inflammatory pseudotumor) and frequently associated with constitutional symptoms; (2) neoplasms with undifferentiated, anaplastic or rhabdoid cell morphology (frequently SWI/SNF-deficient) associated with diverse paraneoplastic manifestations; and (3) paraneoplasia associated with neoplasms carrying specific gene fusions such as solitary fibrous tumor (STAT6-NAB2 gene fusions), infantile fibrosarcoma and congenital mesoblastic nephroma (ETV6-NTRK3 gene fusions), and angiomatoid fibrous histiocytoma (EWSR1-CREB1 & EWSR1-ATF1 fusions).
|
30819530 |
2019 |
|
Thymic Clear Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
EWSR1 translocation in primary hyalinising clear cell carcinoma of the thymus.
|
31050844 |
2019 |
|
Childhood Atypical Teratoid/Rhabdoid Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
ES is typically characterized by rearrangement of the EWSR1 locus and ATRT by deletion of SMARCB1.
|
28382842 |
2019 |
|
Glioneuronal tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
EWSR1-PATZ1 gene fusion may define a new glioneuronal tumor entity.
|
29679497 |
2019 |
|
Thymus Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Because the immunophenotype is unspecific, testing for the EWSR1 translocation might be helpful in discriminating this entity from other thymic neoplasms or metastases, in particular those with clear cell change.
|
31050844 |
2019 |
|
Childhood Undifferentiated Pleomorphic Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, the splicing events of certain STS key genes were significantly associated with STS 2-year overall survival in the present study, including exon skip (ES) events in MDM2 and EWSR1, alternate terminator events in CDKN2A and HMGA2 for dedifferentiated liposarcoma, ES in MDM2 and alternate promoter events in CDKN2A for leiomyosarcoma, and ES in EWSR1 for undifferentiated pleomorphic sarcoma.
|
31443718 |
2019 |
|
Ewing-like sarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma.
|
30895378 |
2019 |
|
Nerve Sheath Tumors
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In the new review all the tumors were re-classified as, ES (n=16), Ewing-like tumor with EWSR1 rearrangement and amplification and possible EWSR1-NFATC2 gene fusion (n=1), CIC-rearranged sarcomas or undifferentiated sarcoma, most consistent with CIC-rearranged sarcoma (n=7), sarcoma with BCOR-alteration or undifferentiated sarcoma, consistent with BCOR-associated sarcoma (n=3), neuroblastoma (n=2), unclassifiable neoplasm with neuroblastic differentiation (n=1), malignant rhabdoid tumor (n=2), lymphoblastic lymphoma (n=1), clear cell sarcoma of the gastrointestinal tract (n=1), small cell carcinoma (n=1), sclerosing rhabdomyosarcoma (n=1), desmoplastic small round cell tumor (n=1), malignant peripheral sheath nerve tumor (n=1), poorly-differentiated synovial sarcoma (n=1), Possible gastrointestinal stromal tumor/GIST with predominant round cells (n=1) and possible SMARCA4-deficient-sarcoma (n=1).
|
29661713 |
2018 |