|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains.
|
8084618 |
1994 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS-erg and EWS-Fli-1, which are involved in greater than 95% of Ewing family of tumors, were shown to function as transcriptional activators.
|
9178886 |
1997 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing's sarcoma family of tumors (EFT) contain reciprocal translocations, of which approximately 90% occur between the long arm of chromosomes 11 and 22,t(11;22)(q24;q12) resulting in the formation of chimeric proteins generated by a fusion of the EWS and FLI-1 genes.
|
9049825 |
1997 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The cytogenetic hallmark of the Ewing family of tumors is t(11,22)(q24;q12) in its simple, complex or variant forms and/or its molecular equivalent EWS/FLI, EWS/ERG rearrangement.
|
9049824 |
1997 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of specific EWS-FLI1 or EWS-ERG transcripts in peripheral blood (PB) samples of patients being treated for ET was prospectively evaluated, and these data were correlated to their clinical status.
|
9836070 |
1998 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As a result of the t(11;22)(q24;q12) chromosomal translocation characterizing the Ewing family of tumors (ET), the amino terminal portion of EWS, an RNA binding protein of unknown function, is fused to the DNA-binding domain of the ets transcription factor Fli1.
|
9704926 |
1998 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Rearrangements of the EWS gene with ETS transcription factor genes as a result of chromosomal translocation and high expression levels of CD99MIC2 characterize the Ewing family of tumors (EFT).
|
10565682 |
1999 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
EWS gene rearrangements, present in essentially 100% of Ewing's Sarcoma/peripheral primitive neuroectodermal tumor, were evaluated by FISH on frozen sections (FS) of tumor biopsies from 10 patients, plus a negative control, and in seven other malignant neoplasms of childhood.
|
10078922 |
1999 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of EWS-FLI-1 fusion in Ewing's sarcoma/peripheral primitive neuroectodermal tumor by fluorescence in situ hybridization using formalin-fixed paraffin-embedded tissue.
|
10088552 |
1999 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we report on cryptic exons found in the chimeric RNA of three EFT with different EWS-FLI1 fusions.
|
10493837 |
1999 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
This fortifies the concept to consider EFT as a spectrum of tumors and suggests the type of EWS fusion transcripts as one, but not the only parameter influencing the extent of differentiation.
|
10492040 |
1999 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genetic hallmark of ESFT is the presence of the t(11;22)(q24;q12), which creates the EWS/FLI1 fusion gene and results in the expression of a chimeric protein.
|
10888417 |
2000 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Soft tissue Ewing sarcoma--peripheral primitive neuroectodermal tumor with atypical clear cell pattern shows a new type of EWS-FEV fusion transcript.
|
10976720 |
2000 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ewing sarcoma family of tumors share recurrent translocations that fuse EWS from 22q12 to five different members of transcription factors namely FLI-1, ERG, ETV1, E1AF and FEV.
|
10949935 |
2000 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The findings also suggest that all cells of the tumors of the Ewing family carry the EWS/FLI-1 fusion transcript.
|
11037342 |
2000 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The method might also accurately diagnose ET-associated translocations other than EWS-FLI and EWS-ERG translocations.
|
11471459 |
2001 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ALK rearrangement may represent the molecular definition of a subgroup of mesenchymal tumors, not always with complete morphological features of IMT, similar to the model of EWS rearrangement in the Ewing sarcoma family of tumors.
|
11284039 |
2001 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, however, it was reported that by using highly sensitive nested RT-PCR, a high proportion of GCT displays chimeric EWS/FLI1 fusion transcripts, i.e., the molecular genetic feature previously known to be strongly associated with the Ewing family of tumors.
|
11519035 |
2001 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since a relation was reported between PDGF-C and EWS/FLI1, we sought to characterize the PDGF signaling pathway in ESFT.
|
12700668 |
2003 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review summarizes the current knowledge about the EWS-FLI1 pathway in EFT and provides some ideas as to how this knowledge may be translated into innovative treatment approaches.
|
12908547 |
2003 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We retrospectively monitored tumor contamination in stem cell harvests from patients with Ewing family of tumors (EFT) all harboring the specific translocation EWS-FLI-1 that characterize these tumors.
|
15049010 |
2004 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore the production of a biologically active recombinant EWS-FLI1 could lead to discoveries that would enhance our mechanistic understanding of ESFT.
|
15491164 |
2004 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ewing sarcoma family of tumors research has benefited from new target discovery and enhanced biologic understanding of the EWS-FLI1 fusion protein.
|
15659957 |
2005 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is not a single condition, but a group of morphologically and clinically closely related disorders with similar molecular biology -- expression of tumor-specific chimeric oncoproteins through balanced chromosomal translocations involving the EWS gene -- often referred to as the Ewing family of tumors.
|
15877528 |
2005 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The translocation t(11;22)(q24;q12) is the most common and leads to the formation of the EWS-FLI1 fusion protein, which contributes to ESFT pathogenesis by modulating the expression of target genes.
|
16096383 |
2005 |