|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
Results were compared to methylation data of 30 EwS with various EWSR1-ETS fusions and one EwS with FUS-ERG fusion, 16 URCS with CIC rearrangement and 10 URCS with BCOR alteration and a total of 81 EWSR1-associated soft tissue sarcomas including 7 angiomatoid fibrous histiocytomas, 7 clear cell sarcomas of the soft tissue, 28 desmoplastic small round cell tumors, 10 extraskeletal myxoid chondrosarcomas and 29 myxoid liposarcomas.
|
30895378 |
2019 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
EWSR1-PATZ1 fusion positive spindle and round cell sarcomas show abundant intratumoral fibrosis and polyphenotypic differentiation, thus mimicking a range of tumors including desmoplastic small round cell tumor.
|
30379650 |
2019 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
EWSR1-PATZ1 is a rare fusion partnering in sarcoma, with few cases reported in the literature.
|
31189996 |
2019 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
EWSR1-PATZ1 fusion is a rare event in tumors: it was only reported in six round cell sarcomas and in three gliomas of three exclusively molecular studies.
|
29679497 |
2019 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
EWSR1-NFATC2 sarcoma is a novel translocation-associated sarcoma.
|
30994538 |
2019 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
Primitive round- or spindle-cell EWSR1-negative undifferentiated sarcomas harboring CIC-DUX4 gene fusion are the most common form of Ewing-like sarcomas.
|
28474974 |
2019 |
|
Sarcoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The current version now includes PEComatous tumors, myoepithelial tumors, and pulmonary myxoid sarcomas with <i>EWSR1-CREB1</i> translocation as new disease entities.
|
30775024 |
2019 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
Expression profile comparisons with tumours of other sarcoma subtypes demonstrated that both cases clustered close to EWSR1-CREB1-positive tumours.
|
29533464 |
2018 |
|
Sarcoma
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Ewing's sarcoma is the second most frequent bone and soft tissue sarcoma, which is commonly driven by the Ewing's sarcoma breakpoint region 1‑friend leukemia integration 1 transcription factor (EWS‑FLI1) fusion gene.
|
30106161 |
2018 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
We retrospectively reviewed all cases of histologically- and molecularly-confirmed CCSLTGT with EWSR1-CREB1 or EWSR1-ATF1 fusions at our tertiary sarcoma center, between 2009 and 2016.
|
29491075 |
2018 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
In the new review all the tumors were re-classified as, ES (n=16), Ewing-like tumor with EWSR1 rearrangement and amplification and possible EWSR1-NFATC2 gene fusion (n=1), CIC-rearranged sarcomas or undifferentiated sarcoma, most consistent with CIC-rearranged sarcoma (n=7), sarcoma with BCOR-alteration or undifferentiated sarcoma, consistent with BCOR-associated sarcoma (n=3), neuroblastoma (n=2), unclassifiable neoplasm with neuroblastic differentiation (n=1), malignant rhabdoid tumor (n=2), lymphoblastic lymphoma (n=1), clear cell sarcoma of the gastrointestinal tract (n=1), small cell carcinoma (n=1), sclerosing rhabdomyosarcoma (n=1), desmoplastic small round cell tumor (n=1), malignant peripheral sheath nerve tumor (n=1), poorly-differentiated synovial sarcoma (n=1), Possible gastrointestinal stromal tumor/GIST with predominant round cells (n=1) and possible SMARCA4-deficient-sarcoma (n=1).
|
29661713 |
2018 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
Recurrent gene fusions involving EWSR1 with members of the cAMP response element binding protein (CREB) family (ATF1 and CREB1) have been reported in a diverse group of tumors including angiomatoid fibrous histiocytoma (AFH), soft tissue and gastrointestinal clear cell sarcoma, primary pulmonary myxoid sarcoma, and hyalinizing clear cell carcinoma of salivary gland.
|
28009602 |
2017 |
|
Sarcoma
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Using JN-DSRCT-1, a cell line derived from DSRCT expressing the EWS-WT1 fusion protein, we investigated the ability of trabectedin to modify the function of the chimeric protein, as in other sarcomas expressing fusion proteins.
|
28166781 |
2017 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
We analysed the spectrum of EWSR1-rearranged soft tissue neoplasms at our tertiary sarcoma centre, by assessing ancillary molecular diagnostic modalities identifying EWSR1-rearranged tumours and reviewing the results in light of our current knowledge of these and other Ewing sarcoma-like neoplasms.
|
28141799 |
2017 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
The Ewing sarcoma breakpoint region 1 (EWSR1) gene is known to fuse with various partner genes to promote the development of the Ewing sarcoma family of tumors and other sarcomas.
|
27627705 |
2016 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
A histologic comparison of the CIC-rearranged sarcomas with 20 EWSR1-rearranged Ewing sarcomas showed significantly higher degrees of lobulation, nuclear pleomorphism, the prominence of the nucleoli, spindle cell elements, and myxoid changes in the CIC-rearranged sarcomas.
|
26685084 |
2016 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
Finally, we demonstrate that EWS-FLI1 contributed to secondary sarcoma development from the sarcoma iPSCs after osteogenic differentiation.
|
26997645 |
2016 |
|
Sarcoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This chapter will focus on the unique genetic and epigenetic changes which characterize these cancers, with an emphasis on translocation-associated sarcomas involving primary gene fusions with the RNA chaperone protein EWSR1.
|
27865462 |
2016 |
|
Sarcoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Study of alternative molecular alterations in EWSR1-negative undifferentiated small round cell sarcomas is clinically relevant, since CIC-DUX4 sarcomas seem to be a very aggressive subset with poor response to the presently used therapeutic regimens.
|
26386605 |
2015 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
Tumor-specific chromosomal translocations create EWS-FLI1 and similar aberrant ETS fusion proteins that drive sarcoma development in patients.
|
26462019 |
2015 |
|
Sarcoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Among the genes that can be rearranged, the EWSR1 gene has been identified as a partner in a wide variety of clinically and pathologically diverse sarcomas as well as some non-mesenchymal tumours.
|
24320889 |
2014 |
|
Sarcoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
All 15 (100%) Ewing sarcomas/PNET and 4 clear cell sarcomas (4/4) harbored EWSR1 translocations.
|
25446247 |
2014 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
The consistent WT1 expression may provide a useful clue in the diagnosis in the context of round cell sarcomas negative for EWSR1 rearrangement.
|
24723486 |
2014 |
|
Sarcoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Gene rearrangements involving the Ewing sarcoma breakpoint region 1 (EWSR1) gene are seen in a broad range of sarcomas and some nonmesenchymal neoplasms.
|
24993903 |
2014 |
|
Sarcoma
|
0.200 |
Biomarker
|
group |
BEFREE |
The identification of fusion genes such as SYT-SSX1/SSX2, PAX3-FOXO1, TPM3/TPM4-ALK and EWS-FLI1 in human sarcomas has provided important insight into the diagnosis and targeted therapy of sarcomas.
|
25300797 |
2014 |